Ovarian Cancer Genetic Testing
What are the benefits of genetic testing for ovarian cancer genes?
About 20% of people diagnosed with ovarian cancer have an that caused their cancer.
- For people with ovarian cancer, genetic test results may affect your cancer treatment options, including allowing you access to newer therapies or to avoid therapies that are less likely to help you.
- Genetic test results may help you and your relatives understand the risk for cancer and take action to stay healthy.
- If you test positive for an , you may have an increased risk for other cancers.
- Your test may allow relatives to learn if they are at increased or average risk for cancer.
- Expert guidelines outline cancer screening and prevention options for people who test positive for a mutation linked to ovarian cancer risk.
Should relatives of people with ovarian cancer get genetic testing?
Yes. National expert guidelines recommend people should speak with a genetics expert about genetic testing if they have any of the following:
- a 1st- or 2nd-degree relative diagnosed with ovarian cancer at any age.
- a personal history of breast cancer and a 1st-, 2nd- or 3rd-degree relative with pancreatic cancer.
- ancestry and a 1st-, 2nd- or 3rd-degree relative with ovarian cancer.
Other criteria may apply. A genetics expert can help you determine if genetic testing is right for you.
Should people who had genetic testing in the past have repeat testing?
People who had genetic testing in the past may benefit from additional genetic counseling and expanded genetic testing if they previously tested negative, and:
- they had a test that only looked for one or a few genes, or
- they had genetic testing before 2014. Genetic testing has improved, and laboratories can now find gene mutations that may have previously been missed.
Which genes are linked to ovarian cancer?
Mutations in the genes listed below are associated with an increased risk for ovarian cancer. The risks vary by gene. See our section with details for each gene to learn more.
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Genes Linked to Ovarian, and Primary Peritoneal Cancer |
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*More research is needed to confirm a link between an in and increased risk for ovarian cancer. **SMARCA4 mutations are associated with a type of ovarian cancer known as a small cell carcinoma of the ovary (hypercalcemic type), also known as SCCOHT. ***STK11 mutations are associated with a type of tumor called sex cord tumors with annular tubules, also known as SCTAT. |
How do I get genetic testing for hereditary ovarian cancer?
Genetic testing is a type of blood or saliva test performed on blood, saliva or tissue. The sample is collected and sent to a genetic testing lab. A doctor or nurse with expertise in genetics or a genetic counselor can help you get genetic testing. You can read more about the process here.