RAD51D: Cancer Treatment
Cancer Treatment for People with Inherited Mutations
Testing positive for an inherited mutation may affect your treatment options or eligibility for clinical trials studying which treatments work best. The following are examples of situations where an mutation may play a part in treatment decision-making. To learn more about treatment options for specific types of cancer, visit our section on cancer treatment by cancer type.
Targeted therapies for advanced cancers
PARP inhibitors are a type of that work by blocking a protein used to repair damaged . People with a mutation who have been diagnosed with cancer may want to ask their doctor about whether they might benefit from therapy or a research study.
PARP inhibitors as after initial treatment for advanced ovarian, or primary peritoneal cancer
Two PARP inhibitors have been approved as after treatment of ovarian cancer based on a known as . Cancers that test HRD-positive may be treated with Lynparza () in combination with Avastin (bevacizumab) or () alone after initial treatment with platinum chemotherapy.
PARP inhibitors or other targeted therapies for advanced cancers with no other treatment options
If you have a mutation and another type of advanced cancer that no longer responds to standard therapy, you may want to talk with your doctor about whether you might benefit from treatment with a or participation in a clinical trial.
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Participate in Research
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Find Compassionate Support
Making treatment decisions may feel overwhelming or isolating. You don't have to face this alone. Find support from people who have been there and understand.
Get Help Locating Resources
Connect with a trained volunteer who can help you navigate the decisions you face about hereditary cancer or cancer risk.
Learn More About Hereditary Cancers
Visit our section with in-depth information on screening, prevention or treatment of different types of cancer.