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Cancer Treatment
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.

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Glossary on

Cancer treatment for people with  mutations

Experts are conducting research studies to learn which treatments work best for people with an inherited  mutation. To learn more about standard of care treatment options for specific types of cancer, visit our section on Cancer Treatment by Cancer Type. People with an mutation who have been diagnosed with cancer may benefit from testing and may qualify for clinical trials looking for more effective treatments for cancer.


Most cancers in people with an inherited  mutation will have a tumor  known as " or "MSI-H" (). This  indicates that the tumor has a feature known as "," which is also known by the abbreviations or . Testing tumors for  or can be important, because these tumors are more likely to respond to  agents known as immune checkpoint inhibitors

MSI-H colorectal cancer

  • In people with 2 colorectal cancer, cancers have a good prognosis and may not benefit from 5-flourouracil (chemotherapy used in colorectal cancer) therapy. 
  • Keytruda (pembrolizumab) is an immune checkpoint inhibitor used to treat  or advanced colorectal cancer that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan.
  • Opdivo (nivolumab) is an immune checkpoint inhibitor used alone or in combination with Yervoy (ipilimumab) for cancer that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan.

Immune checkpoint inhibitors for treating any MSI-H cancer

  • Keytruda (pembrolizumab) is approved for the treatment of any that test MSI-H, have progressed after treatment and for which there are no other treatment options.

endometrial cancer

  • Jemperli (dostarlimab) is an that is approved to treat recurrent and advanced endometrial cancer that is mismatch repair-deficient.

PARP inhibitors

PARP inhibitors are a type of that work by blocking a protein used to repair damaged

PARP inhibitors for prostate cancer

The Talzenna () has received FDA-approval to treat men with , , who have a mutation in or other genes linked to a certain type of damage repair. 

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

Paying For Care
Paying For Care

Paying for cancer treatment

The majority of public and private health insurance plans are required to cover cancer diagnosis and treatment; copays, coinsurance and deductibles often apply. Patient costs and coverage for specific doctors, facilities or treatments may vary based on your health plan. Visit our section on Insurance and Paying for Care: Treatment  for more information, links to sample appeal letters and other resources. 

If you need information about finding an insurance plan, watch our video: Choosing Wisely: How to Pick Insurance Plans.

Some pharmaceutical companies have assistance programs that help cover the cost for their medications: 

Organizations that offer co-pay assistance:

Other resources:

  • The American Cancer Society provides information and resources on covering the cost of cancer care. Public assistance, such as Medicaid may be available if you are ineligible for other programs. 
  • Needy Meds: Assistance programs to help patients with cost of medications and other healthcare.
  • Triage Cancer offers tools and resources to help individuals cope with the financial aspects of a cancer diagnosis.

Open Clinical Trials
Open Clinical Trials


The following studies are enrolling people with advanced colorectal cancer. 

Several other clinical trials for patients with colorectal cancer can be found here.

Open Clinical Trials
Open Clinical Trials

The following studies are enrolling people with advanced endometrial cancer.  

A number of other clinical trials for patients with endometrial cancer can be found here.

Last updated December 31, 2023