Hereditary Cancer and Genetic Testing

Other medical concerns for people with inherited TP53 mutations

Because of the high lifetime risk and early onset of cancer with Li-Fraumeni syndrome, people of reproductive age may wish to speak with a fertility expert prior to having children. There are options using assisted reproduction technology and preimplantation genetic diagnosis for parents to select embryos that are free of an inherited TP53 mutation. 

Research shows that people with Li-Fraumeni syndrome are sensitive to the effects of radiation. Experts recommend that people with Li-Fraumeni syndrome avoid radiation exposure as much as possible.