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TP53 (Li-Fraumeni Syndrome): Other Considerations
Learn about other health implications for people with Li-Fraumeni syndrome due to a TP53 mutation. Stay up to date by signing up for our community newsletter.
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Other Medical Concerns for People with Inherited Mutations
Because of the high lifetime risk and early onset of cancer with , people of reproductive age may wish to speak with a fertility expert prior to having children. There are options using assisted reproductive technology and preimplantation genetic diagnosis for parents to select embryos that are free of an inherited TP53 mutation.
Research shows that people with Li-Fraumeni syndrome are sensitive to the effects of radiation. Experts recommend that people with Li-Fraumeni syndrome avoid radiation exposure as much as possible.
Participate in research
The LiFT UP Li-Fraumeni & TP53: Understanding & Progress Study
Clinicaltrials.gov identifier: NCT04541654
Visit our partner
Li-Fraumeni Syndrome Association
LFSA provides information, advocacy and resources for individuals and families with Li-Fraumeni syndrome.
Last updated June 10, 2025