CDK4 Gene Mutation

What is CDK4?

 CDK4 is a gene that helps control cell growth. People who are born with changes—called mutations—in their CDK4 gene have an increased risk for certain types of cancer.   

What are the cancer risks associated with a CDK4 mutation?

People with an inherited mutation in CDK4 have an increased risk for melanoma and possibly pancreatic cancer. 

What can people with a CDK4 mutation do?

Experts have created guidelines which outline recommendations for managing risk in people with a CDK4 mutation. There may be family planning concerns and options for people with an inherited CDK4 mutation. 

If you test positive for an inherited CDK4 mutation, you should inform your close blood relatives (first-, second-, and third-degree relatives) about your test results and encourage them to speak with a genetics expert. 

Does everyone with a CDK4 mutation develop cancer?

Although the lifetime risk for cancer with a CDK4 mutation is high, not everyone with a mutation develops cancer. Following the guidelines for screening and prevention increases the chances of preventing cancer or catching it at its earliest and most treatable stage.