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CDK4 Gene Mutations: Cancer Risk

Learn about the cancer risks associated with mutations in the CDK4 gene. Stay up to date by signing up for our community newsletter.

Hereditary Cancer and Genetic Testing > Hereditary Cancer Genes and Risk > Risk Management and Treatment by Mutation > CDK4 > Cancer Risk

The Basics CDK4 Gene Mutations: Cancer Risk CDK4: Options for Managing Cancer Risk CDK4: Options for Cancer Treatment CDK4: Other Considerations
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Cancer Risk Associated with Inherited CDK4 Mutations

If you have tested positive for an inherited CDK4 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.

  • People who have a CDK4 mutation have a very high lifetime risk of developing melanoma, which may be as high as 80%. The lifetime risk for melanoma in someone without a mutation is about 2.5 percent.
  • People with a CDK4 mutation may have an increased risk of developing pancreatic cancer. More research is needed to confirm this link. 
Last updated June 29, 2024