Get notified of page updates
Cancer Risk
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.

Stay up to date on research and information

Sign Up for FORCE Newsletters
Glossary on

Cancer Risk Associated with Inherited CDK4 Mutations

If you have tested positive for an inherited CDK4 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.

  • People who have a CDK4 mutation have a very high lifetime risk of developing melanoma, which may be as high as 80%. The lifetime risk for melanoma in someone without a mutation is about 2.5 percent.
  • People with a CDK4 mutation may have an increased risk of developing pancreatic cancer. More research is needed to confirm this link. 
Last updated December 30, 2023