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CDK4 Gene Mutations: Cancer Risk

Learn about the cancer risks associated with mutations in the CDK4 gene. Stay up to date by signing up for our community newsletter.
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Cancer Risk Associated with Inherited Mutations

If you have tested positive for an inherited  mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.

Cancer Type

Risk with a Mutation

Lifetime Risk for General Population

Melanoma

Up to 80%

2.5%

Pancreatic cancer

May be elevated, more research is needed to confirm this link.

Less than 1%

More Resources

Find Compassionate Support

Making treatment decisions may feel overwhelming or isolating. You don't have to face this alone. Find support from people who have been there and understand. 

 

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Get Help Locating Resources

Connect with a trained volunteer who can help you navigate the decisions you face about hereditary cancer or cancer risk. 

 

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Learn More About Hereditary Cancers

Visit our section with in-depth information on screening, prevention or treatment of different types of cancer.

 

 

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Find a Dermatologist

The American Academy of Dermatology has a tool to find dermatologists by expertise, location or procedure. 

Click Here

NCCN Patient Guidelines for Melanoma

The National Comprehensive Cancer Network has patient guidelines to help people diagnosed with melanoma make informed decisions.

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AIM at Melanoma Foundation

FORCE partner, AIM at Melanoma Foundation has detailed information to help people understand their diagnosis and treatment options.

Click Here

Last updated September 21, 2026