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CDK4 Gene Mutations: Cancer Risk

Learn about the cancer risks associated with mutations in the CDK4 gene. Stay up to date by signing up for our community newsletter.
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Cancer Risk Associated with Inherited Mutations

If you have tested positive for an inherited  mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.

Cancer Type

Risk with a Mutation

Lifetime Risk for General Population

Melanoma

Up to 80%

2.5%

Pancreatic cancer

May be elevated, more research is needed to confirm this link.

Less than 1%

Find a Dermatologist

The American Academy of Dermatology has a tool to find dermatologists by expertise, location or procedure. 

Click Here

NCCN Patient Guidelines for Melanoma

The National Comprehensive Cancer Network has patient guidelines to help people diagnosed with melanoma make informed decisions.

Click Here

AIM at Melanoma Foundation

FORCE partner, AIM at Melanoma Foundation has detailed information to help people understand their diagnosis and treatment options.

Click Here

Last updated July 27, 2025