Risk management for people with inherited CDK4 mutations
The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for men and women with CDK4 mutations. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type.
Melanoma screening and prevention
- Perform regular self-exams to look for skin changes. Have a friend or family member help with hard to see areas of the body.
- Watch moles closely for any signs of change in shape, size, or color.
- Dermatologists may take pictures of the skin and moles, known as mole mapping, or view moles with a hand-held device known as a dermatoscope. Any suspicious moles or other skin changes should be removed by a doctor so the tissue can be analyzed under a microscope.
- Due to the high risk of multiple melanomas, people with familial melanoma and/or CDK4 gene mutations should avoid sun exposure and take steps to protect themselves when outdoors.
- Children in families that have familial melanoma and/or CDK4 gene mutations should begin screening by age 10.
- In people that have had melanoma, thorough skin exams should be performed every 3 to 6 months by a dermatologist.
If you are a person with a CDK4 mutation, you can find peer support through the following resources:
- Register for the FORCE Message Boards to connect with others who share your situation. Once you register, you can post on the Share Your Mutation board to connect with other people who carry a CDK4 mutation and the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- FORCE's Peer Navigation Program will match you with a volunteer who shares your mutation and situation and provide you with a free resource guide.
- Contact the FORCE impact leaders in your area to link to local support groups and other resources.
- Attend a virtual support meeting in your area.
- Read the stories from members of our community.
Other organizations that provide support for people diagnosed with melanoma include:
- AIM at Melanoma is a nonprofit organization that has online support and a list of in-person support groups by region.
The following screening and prevention studies may be open to people with a CDK4 mutation.
- NCT04062032: Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma. This is an open label phase II pilot study assessing the metabolomic and inflammatory effects of oral aspirin (ASA) in human subjects at risk for melanoma.
- NCT04066725: Aspirin as an Ultraviolet (UV) Protectant in Human Subjects at Risk for Melanoma. This is a phase II trial assessing aspirin (ASA) as a UV protectant in patients at risk for melanoma.
- NCT03725449: Internet-based Intervention for Skin Self-Examination in Participants With Increased Risk for Melanoma. This trial studies an internet-based intervention for skin self-examination (SSE) in participants at increased risk for melanoma.