Risk Management for People with Inherited CDK4 Mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for men and women with CDK4 mutations. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type. 

Melanoma screening and prevention

• Perform regular self-exams to look for skin changes. Have a friend or family member help with hard to see areas of the body.
• Watch moles closely for any signs of change in shape, size, or color.
• Dermatologists may take pictures of the skin and moles, known as mole mapping, or view moles with a hand-held device known as a dermatoscope. Any suspicious moles or other skin changes should be removed by a doctor so the tissue can be analyzed under a microscope.
• Due to the high risk of multiple melanomas, people with familial melanoma and/or CDK4 gene mutations should avoid sun exposure and take steps to protect themselves when outdoors.
• Children in families that have familial melanoma and/or CDK4 gene mutations should begin screening by age 10.
• In people that have had melanoma, thorough skin exams should be performed every 3 to 6 months by a dermatologist.