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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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91 through 100 of 109

Relevance: Medium

Strength of Science: Medium-High

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Study : Does IVF increase a woman’s risk for breast cancer?

Most relevant for: Woman at average risk for breast cancer who have or are considering undergoing In Vitro Fertilization

In vitro fertilization (IVF) wasn't commonly used until the 1980s, so its long-term effects are mostly unknown. A new study suggests that the treatment does not increase a woman's risk for developing breast cancer. (8/23/16)

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

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Study : Early research on a drug to prevent breast cancer

Most relevant for: Women with a BRCA1 mutation

Many researchers are interested in non-surgical options to reduce the higher-than-average risk of developing breast cancer in BRCA mutation carriers. This research study identified a type of drug, called a “RANK ligand inhibitor,” that may prevent breast cancer. Among mice that were genetically engineered to have no BRCA1 genes, those that were given the drug developed tumors less frequently than those that did not. While this is an exciting early study for BRCA mutation carriers, more work and human clinical trials need to be done before this can be used as a prevention therapy in humans. (7/12/16)

Update added 11/24/19: The RANK ligand inhibitor, denosumab is currently being studied as a possible breast and ovarian cancer preventive agent in human clinical trials.

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

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Study : Breast cancer risk model updated for average risk women with genetic, lifestyle and environmental information

Most relevant for: Women at average risk for breast cancer

A number of factors are known to increase breast cancer risk, but some of these factors have not been included in models to predict breast cancer risk. This study looks at an updated model that includes some of these factors, such as genetics, smoking, and drinking. The goal of the model is to give women a more individualized breast cancer risk assessment. (6/29/16)

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Relevance: Medium-High

Strength of Science: Medium

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Study : Does light alcohol consumption affect your breast cancer risk?

Most relevant for: Women who drink alcohol and are concerned about their breast cancer risk.

Alcohol is known to increase breast cancer risk, but does that include light consumption? This study indicates that some breast cancer occurrences and mortality is due to light alcohol consumption. (06/21/16)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : Dense breast notifications are informative but hard to read and understand

Most relevant for: Women with dense breast tissue on mammograms

Some states offer women dense breast notifications that are meant to explain that dense breasts are risk factors for breast cancer and can hide cancer on mammograms, and to identify appropriate supplemental screening options. But recent research found that this information is often not easy to read or understand, which questions the usefulness of the documents. (6/7/16)

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

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Study : Is breast cancer risk increased in women who test negative for the BRCA mutation in their family?

Most relevant for: Women from a family with a known BRCA mutation who tested negative for the mutation in the family

Some women who do not carry a BRCA mutation, but come from a BRCA-positive family, still develop breast cancer. This research examines whether these women are at higher risk for breast cancer, or whether their risk is similar to women in the general population. (4/19/16)

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Relevance: Medium

Quality of Writing: Medium-Low

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Article : New York Times report demonstrates need for genetic counseling, but doesn’t give the whole story

Most relevant for: People diagnosed with breast cancer

A New York Times report discussed how genetic testing could provide “grim data” without guidance for patients. While this is a valid concern, this report does not sufficiently emphasize certain important issues regarding genetic testing, particularly the need for genetic counseling by a health care provider with expertise in genetics before and after genetic testing. (4/5/16)

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Relevance: Medium-High

Strength of Science: High

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Study : BRCA testing in young women with breast cancer

Most relevant for: Young women diagnosed with breast cancer who have not yet had genetic testing

National guidelines recommend genetic testing for BRCA mutations in young women who are diagnosed with breast cancer. However, little is known about how women decide to get testing, or how they use genetic information to decide on treatment options. This study found that genetic testing is increasing among young breast cancer survivors, and it explores some of the factors that play into patients’ decision making about genetic testing. (3/22/16)

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Relevance: Medium-High

Strength of Science: Medium

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Study : Do women who eat a high fiber diet have a lower risk of breast cancer?

Most relevant for: Adolescent and young adult women

Some researchers believe that dietary fiber may decrease breast cancer risk by lowering estrogen levels in the blood. However, many previous studies have failed to find a link between fiber consumption and lower breast cancer risk. The current study suggests that consuming high dietary fiber during adolescence and young adulthood may lower breast cancer risk, but more work needs to be done to confirm this finding. In the meantime, everyone is encouraged to eat a variety of high fiber foods for the many well-documented health benefits. (03/08/16)

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Post Approval

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Study : What are the genetics underlying 12 different cancer types?

Most relevant for: People diagnosed with cancer

As gene sequencing has become more affordable, researchers and health care providers are now looking for mutations in many genes beyond BRCA1, BRCA2 and others that are associated with known hereditary cancer syndromes. By sequencing thousands of genes rather than just one or two, researchers can better understand which inherited mutations affect cancer risk. In this study, researchers sequenced thousands of genes in patients with one of 12 cancers, including breast, and catalogued which gene mutations are most commonly found in each cancer. (03/01/16)

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