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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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201 through 210 of 323

Relevance: High

Strength of Science: Medium-High

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Study : Declining use of chemotherapy for early-stage breast cancer: examining oncologist recommendations

Relevance: High

Strength of Science: Medium-High

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Most relevant for: People diagnosed with early stage breast cancer

A new study shows that chemotherapy use for early-stage, node-positive and node-negative breast cancers declined from 2013 to 2015. It also reports that oncologists’ recommendations are influenced to differing degrees by patient preferences and tumor test results, despite unchanging health care guidelines. (8/21/18)

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Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Human Research

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Study : Immunotherapy may lead to long-term remission of metastatic breast cancer

Relevance: Medium-High

Strength of Science: Medium

Research Timeline: Human Research

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Most relevant for: People with advanced cancers

Metastatic breast cancer is often difficult to treat. In a new approach, called adoptive cell therapy (ACT), a patient’s own T-cells (a type of cancer-fighting immune cells) are collected, multiplied in a lab, and then returned to the patient. The goal is to enhance the patient’s immune system with many more T-cells that recognize and attack metastasized tumor cells. This study reports on a single patient whose metastatic breast cancer is still in remission (no evidence of disease) after more than 22 months following ACT. (8/16/18)

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Relevance: Medium

Quality of Writing: Medium-Low

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Article : Interview with Angelina Jolie's doctor promotes meatless diet and scientific inaccuracies

Relevance: Medium

Quality of Writing: Medium-Low

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Most relevant for:

Dr. Kristi Funk, Angelina Jolie's Hollywood breast surgeon, is promoting her new book about breast cancer. This article from the UK newspaper The Times includes an interview with Funk about her book, which proposes that diet is responsible for breast cancer. This XRAYS addresses scientific inaccuracies in this article. (8/7/18)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

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Study : Some women with early-stage breast cancer forego chemotherapy

Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: People with node-negative, ER-positive breast cancer

A research study named the “Trial Assigning Individualized Options for Treatment” (TAILORx) asked whether chemotherapy is beneficial for women who have mid-range Oncotype DX tumor recurrence scores. This trial — the largest breast cancer treatment trial ever conducted— showed that endocrine therapy alone was as effective as endocrine therapy plus chemotherapy in women with certain types of early-stage breast cancer. The results of this trial are expected to be immediately practice changing (7/20/18)

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Relevance: High

Quality of Writing: High

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Article : High health insurance deductibles can interfere with breast cancer treatment decisions

Relevance: High

Quality of Writing: High

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Most relevant for: People diagnosed with breast cancer

A New York Times article published on May 4, 2018 examines the impact of high insurance deductibles on breast cancer treatment. (7/12/18)

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Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

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Study : Evaluation of some direct-to-consumer genetic testing reveals inaccuracies and misinterpretations

Relevance: Medium

Strength of Science: Medium

Research Timeline: Human Research

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Most relevant for: People who are considering or have had direct-to-consumer testing

A clinical genetic testing laboratory examined results from direct-to-consumer genetic testing ordered directly by patients. They found many instances of false positives—reported mutations that were not actually present—and in some cases, reports of variants that "increased risk," but were actually benign. This study emphasized the importance of involving genetics experts in the interpretation of genetic test results. (6/28/18)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Study : Disparities in research impact breast screening guidelines

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

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Most relevant for: Women at average risk for breast cancer

For women at average risk of breast cancer, the United States Preventive Services Task Force (USPSTF) currently recommends beginning annual breast cancer screening at age 50. However, because these guidelines are largely based on data from white women, they may not be sensitive to racial differences.  A new study assesses the age distribution of breast cancer cases across race/ethnicity in the U.S. (6/21/18)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Study : Mutations in Lynch syndrome genes MSH6 and PMS2 may be associated with breast cancer

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Human Research

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Most relevant for: Women with an MSH6 or PMS2 mutation

Some women with mutations in MSH6 and PMS2, two Lynch syndrome genes, may have a modest (2 to 3-fold) increased risk for breast cancer. (6/14/18 updated 09/25/19)

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Relevance: High

Quality of Writing: Medium-High

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Personal Story : Juliet's story: No reconstruction is a post-mastectomy option

Relevance: High

Quality of Writing: Medium-High

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Most relevant for: Women who have had or are considering mastectomy without reconstruction

In a March 2018 article from breastcancercare.org, Juliet conveys her personal experience with a breast cancer diagnosis and her decision to not have her breasts reconstructed after her mastectomy. She details the emotional complexity of her thought process and the empowerment she felt in her decisions. (5/24/18)

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Human Research

Study : Metastasis is affected by wound healing and inflammation in study on mice

Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Human Research

Most relevant for: Cancer patients who will be, or have recently undergone surgery

This study in mice looked at how wound healing after surgery affects metastasis. Researchers found that wound healing caused changes in the mouse immune system that allowed some cancer cells to grow, but that treatment with a non-steroidal anti-inflammatory drug (NSAID) reduced inflammation and frequency of metastases. While this research is promising, it remains to be seen if similar effects occur in humans. (5/17/18)

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