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Other Cancers

Learn about the specific risks for cancers associated with HBOC.

Colorectal cancer

Colorectal cancer refers to cancer affecting the large intestines or the rectum. In the general population the average lifetime risk for colorectal cancer is about 6%. Early studies on BRCA showed a small increase in colon cancer risk. More recent studies have shown mixed results with some showing no elevation of colorectal cancer risk and others showing an increased risk.

Other gene mutations associated with increased breast and/or ovarian cancer risk have been shown to increase colorectal cancer risk.  

  • Lynch Syndrome, also known as Hereditary Nonpolyposis-Colorectal Cancer (HNPCC), a hereditary syndrome linked to uterine and ovarian cancer, elevates the risk for colorectal cancer.
  • Familial adenomatous polyposis (FAP) is a hereditary syndrome linked with young onset colorectal cancer.
  • CHEK2 mutation carriers are known to be at increased risk of colorectal cancer as well.

If colorectal cancer runs in your family, it is important to consult with a genetics specialist to determine risk and management options. You may be eligible for increased colon cancer screening based on family history alone. 

Updated 09/22/2018

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