Risk management for people with inherited MUTYH mutations
MUTYH-associated polyposis (MAP)
Experts guidelines on risk-management for people with MAP are listed below. Importantly, these risks and interventions do not apply to people who have a mutation in only one copy of their MUTYH gene. See below for the specific risk-management options for people with 1 MUTYH mutation.
|High quality colonoscopy every 1-2 years, depending on findings.
|Annual physical exam; baseline thyroid (frequency of follow-up depends on findings).
|Baseline upper endoscopy (frequency of follow-up depends on number, size, and type of found), typically with a specialized scope that can evaluate the ampullar of Vater.
|For individuals with a personal history of cancer, and/or a high polyp burden
|Consider total colectomy with ileorectal anastomosis, followed by sigmoidoscopy at least once yearly to screen remaining large bowel tissue. See our section on colectomy for a description of this procedure.
|No specified age
|Speak with your doctor about the benefits and risks of risk-reducing medications.
|People with a mutation in only one copy of their MUTYH gene who have a first degree relative with colorectal cancer are recommended to begin colorectal cancer screening at age 40 (or younger depending on family history of cancer). Recommendations include a high-quality colonoscopy every 5 years.