Get notified of page updates
Glossary on

Risk management for people with inherited MUTYH mutations

MUTYH-associated polyposis (MAP) 

Experts guidelines on risk-management for people with MAP are listed below. Importantly, these risks and interventions do not apply to people who have a mutation in only one copy of their MUTYH gene. See below for the specific risk-management options for people with 1 MUTYH mutation. 


Beginning age Recommendation


High quality colonoscopy every 1-2 years, depending on findings.
25-30  Annual physical exam; baseline thyroid (frequency of follow-up depends on findings).
30-35 Baseline upper endoscopy (frequency of follow-up depends on number, size, and type of found), typically with a specialized scope that can evaluate the ampullar of Vater.
For individuals with a personal history of cancer, and/or a high polyp burden Consider total colectomy with ileorectal anastomosis, followed by sigmoidoscopy at least once yearly to screen remaining large bowel tissue. See our section on colectomy for a  description of this procedure. 
No specified age Speak with your doctor about the benefits and risks of risk-reducing medications. 

Screening for people with a mutation in one of their MUTYH genes

People with a mutation in only one copy of their MUTYH gene who have a first degree relative with colorectal cancer are recommended to begin colorectal cancer screening at age 40 (or younger depending on family history of cancer). Recommendations include a high-quality colonoscopy every 5 years. 


Last updated January 01, 2024