MUTYH: Options for Managing Cancer Risk
Risk Management for People with Inherited MUTYH Mutations
MUTYH-associated polyposis (MAP)
Experts guidelines on risk-management for people with MAP are listed below. Importantly, these risks and interventions do not apply to people who have a mutation in only one copy of their MUTYH gene. See below for the specific risk-management options for people with 1 MUTYH mutation.
Beginning Age |
Recommendation |
25-30 |
Annual physical exam. |
25-30 (or earlier based on family history) |
High-quality colonoscopy. |
30-35 |
Baseline upper endoscopy (frequency of follow-up depends on number, size, and type of polyps found), typically with a specialized scope that can evaluate the ampullar of Vater. |
For individuals with a personal history of cancer, and/or a high polyp burden |
Consider total colectomy with ileorectal anastomosis, followed by scoping at least once yearly to screen remaining large bowel tissue. See our section on colectomy for a description of this procedure. |
No specified age |
Speak with your doctor about the benefits and risks of risk-reducing medications. |
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric vs. 1 2024 |
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