Hereditary Cancer and Genetic Testing

Other medical concerns for people with inherited STK11 mutations

People with Peutz-Jeghers syndrome develop noncancerous tumor-like growths called hamartomas. These growths most often form in the gastrointestinal tract, especially in the stomach and intestines. 

Children with Peutz-Jeghers syndrome often develop small, dark-colored spots on the lips, around and inside the mouth, near the eyes and nostrils, and around the anus. These spots may also occur on the hands and feet. These spots appear during childhood and often fade as the person gets older. Most people with Peutz-Jeghers syndrome develop multiple polyps in the stomach and intestines during childhood or adolescence. Polyps can cause health problems such as recurrent bowel obstructions, chronic bleeding, and abdominal pain beginning at a young age. 

Because of the high lifetime risk and early onset of medical issues with Peutz-Jeghers syndrome, people of reproductive age may wish to speak with a fertility expert prior to having children. There are options using assisted reproduction technology and preimplantation genetic diagnosis for parents to select embryos that are free of an inherited STK11 mutation.