Hereditary Cancer and Genetic Testing

Risk management for people with inherited NBN mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for people with an NBN mutation. If you have tested positive for the 657del5 NBN mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk management plan. Consider participating in a clinical trial to help experts learn the best options for someone with an inherited NBN mutation. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type.

Breast cancer screening and prevention

  • Breast awareness starting at age 18.
  • Clinical breast exam every 6 to 12 months starting at age 40.
  • Annual mammography with consideration of tomosynthesis and breast MRI with contrast beginning at age 40 or 5-10 years earlier than the youngest breast cancer in the family.  
  • There is not enough research for NCCN to recommend risk-reducing mastectomy for women with an NBN mutation. Consideration of risk-reducing mastectomy may be based on personal and family history of cancer.

Ovarian cancer screening and prevention

There is not enough research to recommend risk-reducing salpingo-oophorectomy for women with an NBN mutation. Consideration of risk-reducing surgery may be based on family history.


If you are a person with an NBN mutation, you can find peer support through the following resources:


The following screening and prevention studies are open to people with an NBN mutation. 

Prostate cancer

Visit our Research Search and Enroll Tool to find additional prevention and screening studies.