Hereditary Cancer and Genetic Testing

Cancer risk associated with an inherited NBN mutation

If you have tested positive for an NBN mutation, we recommend consulting with a genetics expert who can assess your personal and family history of cancer, and can help you determine the best risk management plan.

Research on cancer risk has focused on one specific NBN mutation, 657del5

  • Women with this mutation have an increased risk of breast cancer. 
  • Women with this mutation may also have an increased risk for developing ovarian cancer.
  • Some research suggests that men with this mutation have an increased risk for aggressive prostate cancer. 
  • There is unknown or insufficient evidence of risk for other cancers in people with an NBN mutation.