Mutations in the NBN Gene
Information for People with Inherited Mutations
People with an in may have an increased risk for certain cancers. There are guidelines for screening and prevention for certain cancers in people with an mutation. There also may be clinical trials available for people who test positive for an mutation.
People diagnosed with an mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials.
Inheriting an mutation from both parents can cause Nijmegen breakage syndrome, a rare condition.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
People with an in may have an increased risk for certain cancers. Cancer risk estimates are updated based on the latest research.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with mutations. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with an mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as Nijmegen breakage syndrome. People with Nijmegen breakage syndrome can have multiple serious health problems and an increased risk for certain cancers.
Participate in Research
The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier:
NCT03805919
Clinicaltrials.gov identifier:
NCT04666740
Clinicaltrials.gov identifier:
NCT04042831
Clinicaltrials.gov identifier:
NCT04030559
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
