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Mutations in the NBN Gene

Learn about the cancer risks, screening, prevention and treatment options for people with inherited NBN mutations. Stay up to date by signing up for our community newsletter.
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Information for People with Inherited Mutations

People with an in may have an increased risk for certain cancers. There are guidelines for screening and prevention for certain cancers in people with an mutation. There also may be clinical trials available for people who test positive for an mutation. 

People diagnosed with an mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. 

Inheriting an mutation from both parents can cause Nijmegen breakage syndrome, a rare condition. 

Each of these topics is outlined in more detail in the sections highlighted below. 

More Information on Mutations

Cancer Risks

People with an in may have an increased risk for certain cancers. Cancer risk estimates are updated based on the latest research.

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Risk Management Options

Read about the latest expert guidelines for cancer screening and prevention for people with mutations. Learn about research studies enrolling high-risk patients. 

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Cancer Treatment Options

People with an mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. 

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Other Considerations

People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as Nijmegen breakage syndrome. People with Nijmegen breakage syndrome can have multiple serious health problems and an increased risk for certain cancers. 

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Last updated February 25, 2024