Keyword: fertility



Relevance: Medium-High


Strength of Science: Medium-High


Research Timeline: Human Research
23 December 2020
Study : Women support delayed removal of ovaries
Most relevant for: Women at high risk of ovarian cancer who are considering undergoing risk-reducing surgery.
Risk-reducing early removal of fallopian tubes followed by removal of ovaries at a later date was acceptable to women at high risk of ovarian cancer due to an inherited mutation in a recent study. This was especially true for women worried about sexual dysfunction associated with surgical menopause. (12/24/20)
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Relevance: Medium-High


Strength of Science: Medium-High


Research Timeline: Human Research
Study : Research on the PARP inhibitor talazoparib (Talzenna) for early-stage breast cancer is promising
Most relevant for: People with early stage breast cancer who have an inherited BRCA mutation
The PARP inhibitor talazoparib (Talzenna) has been useful for treatment of advanced or metastatic breast cancer for patients with BRCA mutations. A preliminary study showed that the majority of patients who took talazoparib alone before surgery for early-stage breast cancer had effective treatment and manageable side effects. Expanded clinical trials are in progress to verify this result. (10/4/19)
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Relevance: High


Strength of Science: High


Research Timeline: Post Approval
Study : Is it safe for BRCA mutation carriers to become pregnant following breast cancer?
Most relevant for: Women with a BRCA mutation who are considering pregnancy after breast cancer
New research shows that pregnancy after breast cancer is safe for women with BRCA mutations and their babies. (9/4/19)
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Relevance: Medium-High


Strength of Science: Medium-High
Study : Diagnosis and treatment delays in young women with breast cancer
Most relevant for: Young women who find a breast lump and young women newly-diagnosed with breast cancer
Young women are more likely to have delays in a breast cancer diagnosis and treatment. Factors that affect these delays include pregnancy, breastfeeding, financial concerns and having a family history of breast or ovarian cancer. (8/5/19)
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Relevance: Medium-High
Study : FORCE online survey: What breast cancer information do young women want and where do they look for it?
Most relevant for: Young women and the health care providers who treat them
FORCE developed the CDC-funded Examining Relevance of Articles to Young Survivors or XRAYS program to help young breast cancer survivors and those at high-risk better understand media coverage about new breast cancer research. To ensure that the program would be responsive to users’ needs, FORCE designed a web-based survey to assess where young women look for information about breast cancer and to learn their unmet information needs. The results of this survey were published in the journal Health Communications. (1/18/19)
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Relevance: Medium-High


Strength of Science: Medium-High


Research Timeline: Human Research
Study : Improving outcomes for young women with breast cancer: fertility and childbearing issues
Most relevant for: Women diagnosed with breast cancer at a young age
Fertility issues and family planning decisions are prominent concerns for young women with breast cancer. This XRAYS looks at Dr. Ann Partridge’s presentation at the 2018 San Antonio Breast Cancer symposium. Her talk, “Breast cancer in young women: Understanding differences to improve outcomes," focused on initial findings from the Young Women's Breast Cancer Study. Dr. Partridge’s research continues in the currently enrolling POSITIVE trial which tests whether women can safely interrupt adjuvant endocrine therapy in order to get pregnant. (1/7/19)
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Relevance: Medium-High


Strength of Science: Medium-High
Study : Breast cancer risk increases modestly after childbirth
Most relevant for: Women in their childbearing years
Does having children alter the risk of breast cancer? Women who give birth have a lower lifetime risk of breast cancer. However, newer data suggests that breast cancer risk increases immediately after childbirth. A study published in December 2018 examines data from the Premenopausal Breast Cancer Collective Group seeking to clarify this issue. (12/28/18)
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Relevance: High


Strength of Science: Medium-High


Research Timeline: Post Approval
Study : Childbearing after breast cancer among young survivors
Most relevant for: Young breast cancer survivors who wish to become pregnant
Women who are diagnosed with breast cancer as an adolescent or young adult often have not yet begun or finished childbearing. Researchers studied the impact of breast cancer and related treatment on birth rates and birth outcomes in young survivors. Overall, adverse birth outcomes were not increased for young survivors compared to women without cancer. However, women with ER-negative breast cancers had a modestly higher frequency of preterm and low weight births. The authors highlight the need for fertility counseling and potential fertility preserving methods prior to treatment. (5/10/18)
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Relevance: Medium-High


Strength of Science: Medium
Study : Take your time, follow your heart: strategies for communication about family planning
Most relevant for: Young high risk women
When a woman is newly diagnosed with a BRCA mutation, she faces many risk management decisions. Although many of these decisions impact family planning, little guidance is available on how to communicate this information. This study examines female previvors’ advice on effective strategies for discussing family planning decisions. (03/28/18)
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Relevance: Medium-High


Quality of Writing: Medium-High
Article : Coping with the financial burden of breast cancer
Most relevant for: People diagnosed with breast cancer
U.S. News & World Report recently talked to three breast cancer survivors, including two young women, about how they handled out-of-pocket costs and other medical expenses after their cancer diagnosis. (Posted 1/4/18)
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