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Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. You can do a quick search to filter our featured studies by cancer type, study type or key word, or a more in-depth search through

Search Results: Prevention, Detection & Risk + Breast Cancer (7 results)

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Restoring Sensation after DIEP Flap Reconstruction

Study for people undergoing DIEP flap reconstruction

Restoring Sensation after DIEP Flap Reconstruction

The goal of this study is to look at how well a nerve graft works for improving sensation to the reconstructed breast after mastectomy in people undergoing DIEP flap reconstruction (deep inferior epigastric perforator flap). 


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Denosumab for breast cancer risk reduction in women with an inherited BRCA1 mutation (The Breast Cancer Prevention Study)

Prevention study enrolling women ages 25-55 with a BRCA1 mutation

Denosumab for breast cancer risk reduction in women with an inherited BRCA1 mutation (The Breast Cancer Prevention Study)

This is a study to test the effectiveness of a drug (denosumab) on preventing the development of breast cancer in women with an inherited BRCA1 mutation.

Denosumab is a drug that is currently used to treat bone loss in order to reduce the risk of broken bones in healthy people, and is also used to reduce new bone growths in cancer patients whose cancer has spread to their bones. Research has shown that denosumab may also reduce the risk of developing breast cancer in women with an inherited BRCA1 mutation.

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Testing  a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

People with a BRCA1 or BRCA2 mutation

Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

This study will look at a new vaccine known as INO-5401 used alone or combined with a second vaccine called INO-9012. The study will test if the vaccine is safe (without large side effects) and test a new way of giving vaccines. It will also test whether the vaccine activates the immune system. A goal of this research is to reduce cancer risk in people with a BRCA1 or BRCA2 mutation. Additional studies will be needed to learn if this vaccine approach lowers cancer risk in mutation carriers. 

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Research Study to Help Improve Family Communication About Inherited BRCA1 or BRCA2 Mutations


Research Study to Help Improve Family Communication About Inherited Mutations

The Ohio State University and FORCE want to understand if a family communication guide for people with BRCA mutations is helpful and if it’s also useful to have a video that you can text or email to family members that explains your BRCA mutation. We are currently looking for people between the ages of 18-80 who have mutation in BRCA1 or BRCA2, have an active email address, and an internet capable device like a computer, tablet, or smartphone.  Participants will be asked to complete a total of 3 surveys.  Participants will be randomly assigned to either receive just the communication guide or the guide plus the sharable.  Each survey will take 10-15 minutes (the study could take up to 1.5 hours to complete depending on how much time you spend reviewing the study materials). 

You can get more information or ask to participate in the study by sending an email to: [email protected].

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Denosumab and Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)


RANKL Inhibition With Denosumab on Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

The purpose of this study is to evaluate if denosumab can reduce the breast density of premenopausal women who have dense breasts. Denosumab is an FDA-approved injectable medication that is used to treat osteoporosis and to prevent fractures in cancer patients with bone metastases. This study could help us identify novel ways to prevent breast cancer in younger women.

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Study for People with Unexpected Genetic Results


Genomic Services Research Program Study for People with Unexpected Genetic Results

A new study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason.

This is a study of people with "secondary results” from genetic testing. Secondary results are unexpected. They are not related to the reason the person had the genetic test but are shared because they may be very important to the person’s health. Most secondary results have to do with high risks for health problems that can be treated or prevented. Many of these results are related to cancer risk. If you think you have received a secondary result, you may be eligible to join this study.

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The WISDOM Study: Women Informed to Screen Depending on Measures of risk

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a mammogram. For more information, visit the WISDOM Study website

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Additional Results on Prevention, Detection & Risk + Breast Cancer
51 results
Clinical Trial Official Title
NCT05376241 Promoting Informed Choice for Breast Cancer Screening
NCT04450264 Increasing African Immigrant Women's Participation in Breast Cancer Screening
NCT04877912 Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
NCT05472064 Design of Chatbot Persona for Breast Cancer Screening Outreach Among Black Women
NCT05298605 Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
NCT05667532 The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
NCT04030507 Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer
NCT05650086 Novel Thermal Imaging Technique for Breast Screening
NCT05051631 BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
NCT03729115 A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
NCT04671498 Droplet-BC Screening Test for the Detection of Breast Cancer, the DROPLET-BC Study
NCT04348123 Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
NCT04904757 Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
NCT05408260 A Study to Compare the Effectiveness of Two Types of Ultrasound Technologies in Women Who Have Had Breast Cancer
NCT04854304 Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT05694559 Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
NCT04085510 Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania
NCT05483283 Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care
NCT03623945 Autoantibodies in Breast Cancer Detection
NCT04086771 Southeast Asian Women's Health Project
NCT03448003 Comprehensive Lifestyle Change To Prevent Breast Cancer
NCT05113485 UCLA Breast Cancer Survivor Health Promotion Research Study
NCT01035112 Magnetic Resonance Imaging of Breast Cancer
NCT04259762 Enhancing Cancer Prevention and Control Pathways-Native Health Initiative
NCT00291096 Protocol for Women at Increased Risk of Developing Breast Cancer
NCT05076266 COVID-19 Related Financial Hardship and Distress in Women Who Decline TMIST (EA1151) Participation
NCT04341129 Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)
NCT03715959 Nipple Aspirate Fluid in Detecting Breast Cancer
NCT05056818 Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics
NCT04763824 KanSurvive: Testing a Model for Improving Cancer Survivorship Care in Rural Practice
NCT05754658 African Cancer Genome: GMD
NCT03147430 Early Detection of Breast Cancer in Women With Suspicious Mammograms
NCT04086875 A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer
NCT04967352 Predicting Chronic Pain Following Breast Surgery
NCT04651452 Writing Interventions in Breast Cancer Patients Taking Aromatase Inhibitors
NCT04722692 Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ
NCT04331535 The Genomic Medicine at VA Study
NCT05721976 With Love, Grandma ("Con Cariño, Abuelita") Pilot Study
NCT04711109 Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
NCT04379414 YES Study - Newly Diagnosed/Metastatic Intervention
NCT00579514 Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
NCT05113927 Wide Field OCT + AI for Positive Margin Rates in Breast Conservation Surgery.
NCT04067726 RANKL Inhibition and Mammographic Breast Density
NCT04009148 Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome
NCT04570722 Ipsilateral Peripheral Intravenous Access Procedures (The iPIVAP Study)
NCT03635632 C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N)
NCT04961996 A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT02694809 The PROMISE Study: Duavee in Women With DCIS
NCT04496739 Making Informed Choices on Incorporating Chemoprevention Into Care (MiCHOICE)
NCT04799665 Dedicated Breast CT for Quantitative Breast Density Measurements in Mexican-origin Women in Southern Arizona
NCT02928978 Ruxolitinib for Premalignant Breast Disease

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