Search Results: (30 results)

This clinical trial is studying whether the combination of two targeted therapies, abemaciclib (Verzenio) and a new targeted therapy  ZEN003694 (also known as ZEN-3694) can be given together safely and what dose should be used in future studies.

This study is testing a new targeted therapy, sacituzumab tirumotecan, given alone or with the immunotherapy Keytruda (pembrolizumab) to treat metastatic, triple-negative breast cancer (TNBC). Keytruda is an immunotherapy that is FDA approved to treat TNBC. The goal of the study is to learn how well sacituzumab tirumotecan can cause tumors to shrink or disappear and how long that response lasts.

This is a Phase 2 treatment trial enrolling adults with advanced pancreatic cancer or advanced non-small cell lung cancer that has continued to grow despite standard immunotherapy.

The FourLight-3 clinical trial compares a study treatment, atrimociclib combined with letrozole, against standard approved treatments. The clinical trial is for adults with advanced or metastatic HR-positive, HER2-negative breast cancer who have not received prior treatment for advanced/metastatic disease. 

The study will test if an investigational treatment, XL309, is safe and works when used alone or in combination with a PARP inhibitor to treat people with some advanced solid tumors. The study is enrolling people with BRCA1 or BRCA2 inherited mutations and have HER2-negative breast cancer, prostate cancer, pancreatic cancer, high grade ovarian, fallopian tube or primary peritoneal cancer; or other solid tumors with certain genetic mutations. 

Survey to identify potential determinants impacting time from symptom onset to ovarian cancer diagnosis

This study is testing a new combination of two oral drugs to see if they are safe and show signs of helping people with advanced cancer whose tumors have mutations in one of these genes: BRCA1, BRCA2, PALB2, ATM, and CHEK2. 

Anonymous online survey enrolling adults with cancer who have met with a surgeon about possible cancer surgery

This phase II trial evaluates how well immunotherapy (toripalimab) works for reducing the risk of cancer recurrence after surgery in patients with mismatch repair deficient stage IIB, IIC, or III colon cancer.

This study is looking at whether people with ovarian cancer do better when they take the drug olaparib (also called Lynparza) for one year or for two years after finishing chemotherapy. Some participants in the study may also get another medicine called bevacizumab (Avastin) along with olaparib. You may be able to join this study if you have stage 3 or 4 ovarian cancer and either a BRCA1 or BRCA2 gene change, or a certain tumor marker called HRD.

This research study will test whether higher doses of radiation therapy are safe and effective for people with locally advanced pancreatic cancer. 

This study is testing a new medication called saruparib (AZD5305) to see if it can help people with prostate cancer that is high risk for getting worse or spreading to other parts of the body. Saruparib is a type of targeted therapy known as a PARP inhibitor. The study is open to people with a BRCA1 or BRCA2 mutation in their tumor. The goal of this study is to find out if adding saruparib after radiation treatment can lower the chances of the cancer coming back or spreading.

This study explores how medical stress affects families with genetic conditions and their relationships with healthcare providers to improve future support.

This research study is testing the safety and effectiveness of an investigational targeted therapy called CX‑5461. The goal is to find a safe dose and learn more about how well the drug works to treat advanced breast, ovarian, pancreatic or prostate cancers in people with certain inherited or tumor‑related gene mutations, including ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, NBN, PALB2, RAD51C, RAD51D or other mutations related to DNA repair.

PREVAIL is a patient-choice study where African American men with prostate cancer or with a strong family history of cancer can choose to either view a pretest genetic education video before having genetic testing or meet with a genetic counselor before genetic testing.

Survey for people diagnosed with cancer

EvoPAR-BR01 is studying two investigational drugs as first-line treatment for HER2-negative, HR-positive, metastatic breast cancer in people with an inherited or tumor mutation in BRCA1, BRCA2 or PALB2. Saruparib is a new PARP1 inhibitor (a type of targeted therapy). Camizestrant is an estrogen receptor degrader (a type of hormonal therapy). The study will look at different combinations of treatments to learn which combination leads to the best survival and fewest side effects. 

This study will look at how often routine MRI scans detect abnormal findings in people with inherited mutations in BRCA1, BRCA2, ATM, and PALB2, who are undergoing pancreatic cancer screening. Researchers want to learn how often MRI and endoscopic ultrasound (EUS) yield abnormal results, and how frequently they find pancreatic cancer or precancer. The study will also review the rate of procedures like biopsies and surgeries among participants. 

This study is looking at the effectiveness of a technology-based information and coaching and support program for Asian American women who have been diagnosed with breast cancer.

The study will determine whether the study medicine mevrometostat can delay or stop the growth of metastatic prostate cancer. Mevrometostat is thought to work by blocking the abnormal EZH2 activity in cells, which may help prevent or delay hormone therapy resistance and cancer growth and progression.

The goal of this treatment study is to learn if the new drug GS-0201 is safe and can help treat people with different types of metastatic or advanced cancer. GS-0201 is a new drug that has not yet been approved for treatment of cancer. GS-0201 is a type of targeted therapy known as a PARP1 inhibitor. 

SOROCk [NRG-CC008] is a clinical trial studying if removal of just the fallopian tubes can reduce the risk of ovarian cancer nearly as much as removing both the ovaries and fallopian tubes among women with an inherited BRCA1 mutation. The main benefit of removing only the fallopian tubes and not the ovaries is to prevent surgically-induced menopause. The study will also examine various patient-reported quality of life outcomes. Researchers believe that most ovarian cancers first begin in the fallopian tubes, suggesting that removing the fallopian tubes only may prevent the development of ovarian cancer. This concept has never been formally testing in a clinical trial.

The FourLight-3 clinical trial tests a study treatment, atrimociclib, plus letrozole against standard approved treatments plus letrozole. The clinical trial is for adults with advanced or metastatic HR-positive, HER2-negative breast cancer who have not received prior treatment for advanced disease.

This study will examine mindfulness training to improve mental health and well-being in younger breast cancer survivors, also known as “HEAL-ABC.” This trial is currently enrolling young breast cancer survivors who have elevated symptoms associated with depression.

The Li-Fraumeni Syndrome Biobank (LFSBB) study is a biobank that collects specimens such as blood and other biomedical samples for individuals who have Li-Fraumeni Syndrome (LFS), unaffected relatives, and household members.

The purpose of this study is to find out if a medication called eRapa can help slow down the formation of polyps in people with Familial Adenomatous Polyposis (FAP).

This clinical trial is studying a new combination of drugs to treat metastatic, HER2-negative or HER2-low breast cancer in people with an inherited mutation in BRCA1, BRCA2 or PALB2 or a tumor mutation in BRCA1 or BRCA2. The study is looking at whether adding a new targeted therapy drug called axatilimab to treatment with the PARP inhibitor olaparib (Lynparza) will improve outcomes in people with metastatic breast cancer. 

This is a study looking at biomarkers to predict recurrence in people with high-risk, early-stage breast cancer who are planning to undergo chemotherapy. This study will follow patients forward over a period of time to see how well the test cancer predict outcomes.

PROMISE is a nationwide registry of prostate cancer patients with inherited mutations; screening approximately 5,000 participants with a prostate cancer diagnosis. The PROMISE team is studying how these mutations affect patient outcomes and hope to help patients learn more about their disease, the treatments that they may benefit most from, and any research studies that they may be eligible for.

This trial will evaluate the optimal dose, safety and effectiveness of an investigational drug called E7386 given together with a targeted therapy called lenvatinib.