Search Results: (30 results)

Phase 2 study comparing talazoparib with or without Enzalutamide in patients with metastatic castration-resistant prostate cancer and an HRR mutation after progression on Abiraterone Acetate or Darolutamide

The study is for people with hormone receptor-positive (HR+), HER2-low or HER2-ultralow breast cancer that has spread to other parts of the body (metastatic) or is locally advanced and cannot be removed with surgery.

This study compares low-dose tamoxifen alone with low-dose tamoxifen plus omega-3 fatty acids in postmenopausal women who are overweight or obese and at increased risk for breast cancer.

The IGNITE-TX study is all about helping people with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome talk to their family members about their risk for cancer and find the best way to get family members tested.

We are conducting a fully-online research study to learn more about how genes affect your risk of breast cancer. No office visit is required. Participants provide consent online, answer questions online about their health and medical history, and provide DNA via a saliva sample using a pre-paid mailer through the mail. In return for participation, study participants may receive information about their genetic ancestry for free.

This study is evaluating whether a mobile app called Moodivate can help improve depressive symptoms in adults living with likely incurable cancer.

Today, researchers are learning about breast cancer from a small subset of patients, who are not representative of all breast cancer patients. ShareForCures® is an online registry that offers people who have been diagnosed with breast cancer a way to participate in research by connecting information about themselves with their breast cancer diagnosis, medical records, genomics. Participation is open to anyone adult, living in the United States, and who has been diagnosed with breast cancer.

People with Lynch syndrome currently rely on regular colonoscopies to screen for colorectal cancer. Researchers are studying whether a simple stool-based test called the fecal immunochemical test (FIT) can help identify people who may need a colonoscopy while reducing the burden of frequent screening. This study will compare FIT results with colonoscopy findings in people with Lynch syndrome.

BEACON is designed to build a comprehensive understanding of the state of prostate cancer awareness and care from the perspectives of men at risk, patient/survivors, caregivers, and healthcare professionals 21 and older.

The CAFÉ Study is investigating how changes in the CTNNA1 gene may be associated with hereditary cancers, including stomach and breast cancer.

This study compares live, online group exercise classes with recorded exercise videos to see how they affect physical activity, physical fitness, quality of life, and loneliness among cancer survivors.

Researchers want to know if a computer program can help choose FDA-approved drugs that will treat advanced breast cancer more effectively. 

This study is designed to learn previvors’ perceptions of their reproductive options and measure their awareness of PGT-M.

This trial will study the safety, tolerability, and initial effectiveness of MOMA-341, a new type of targeted therapy, alone or in combination with a standard chemotherapy (irinotecan) or together with an immunotherapy to treat people with advanced or metastatic cancers with certain types of mutations.

This study is looking at genetic testing in newly-diagnosed colorectal cancer patients and comparing different ways of helping family members learn about their potential inherited cancer risk and access genetic testing.

The purpose of this study is to understand gastric (stomach) cancer risk among people with an inherited (germline) mutation in genes that are linked to an increased risk of certain cancers, including APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM), MUTYH, STK11, and other genes linked to increased cancer risk. 

A diagnosis of cancer or other serious medical condition changes everything — including your mental health. Those experiencing negative mental health changes after receiving a diagnosis may be dealing with what is known as Adjustment Disorder.

This study tests whether COM701 (an anti‑PVRIG immunotherapy) given every 3 weeks as maintenance can delay cancer growth after a good response to platinum chemotherapy. Adults with relapsed platinum‑sensitive ovarian, fallopian tube, or primary peritoneal cancer are randomized 2:1 to COM701 or placebo.

This study is testing a new drug called DT2216 in combination with the chemotherapy drug paclitaxel for people whose ovarian cancer has returned and no longer responds to platinum-based chemotherapy.

The Vanguard Study is looking at how multi-cancer detection (MCD) blood tests could fit into cancer screening.

The researchers are doing this study to see if the drug romosozumab is effective at helping with bone formation in people with metastatic breast cancer (MBC) that has spread to the bones. The researchers will also look at bone breakdown (resorption) in participants and determine if romosozumab is a safe treatment for osteoporosis in people with MBC that has spread to the bones.

This clinical trial is testing whether using acupressure guided by the EnergyPoints App can reduce cancer-related fatigue and improve sleep in adult cancer survivors residing in the U.S.

Researchers are studying certain rare variants in the BRCA1 and BRCA2 genes that may affect cancer risk differently than more common harmful variants in BRCA1 and BRCA2. The goal is to learn more about the cancer risks associated with these specific variants and help improve recommendations for cancer screening and prevention.

This study is evaluating the addition of ART6043, a novel targeted therapy, to olaparib, a standard treatment, in adults with HER2-negative advanced or metastatic breast cancer and an inherited germline BRCA mutation.

This study is looking at whether psilocybin-assisted psychotherapy may help people with advanced cancer who are experiencing significant anxiety, depression, or emotional and spiritual distress related to their cancer.

This study will compare two treatment approaches for platinum-sensitive ovarian cancer that has progressed after PARP inhibitor maintenance therapy..One group of participants will receive a combination of the medications sacituzumab govitecan (Trodelvy) and bevacizumab (Avastin) and the other group will receive standard of care chemotherapy plus bevacizumab.

This Patient and Caregiver survey was created by volunteers from two non-profit groups to learn more about immunotherapy side effects. No personal information is collected. Goals include sharing results with doctors, care teams, and patient groups; gathering information about better ways to handle immune-related side effects; and working with researchers to find and test better ways to treat immune-related side effects.

In this study, researchers are testing the safety and effectiveness of the immunotherapy dostarlimab (Jemperli) as a non-surgery alternative  treatment option for patients with early-stage dMMR or MSI-H endometrial cancer and a strong desire for fertility preservation. Doctors will evaluate patients' response to dostarlimab; patients whose tumors respond completely can be followed with close surveillance and no surgery. 

This study is collecting feedback on educational materials about breast MRI from Black and Latina women ages 18-74 who are at high risk for breast cancer.

This study is for adults with advanced/metastatic HR-positive, HER2-negative advanced or metastatic breast cancer who have previously been treated with a CDK4/6 inhibitor and have received two or less treatments for their advanced metastatic breast cancer.