The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
Prevention
Prostate cancer screening study for male US veterans age 55–69
Clinicaltrials.gov identifier:NCT05926102
Study Contact Information:
Name: Charles A Brunette, PhD
Phone Number: (857) 364-6324
Email: [email protected]
About the Study
This study is testing using a person’s genetics to guide screening that can make cancer testing more accurate and reduce harms. Participants will have genetic testing to estimate their risk for cancer.
The study will use this genetic information to give Veterans and their primary care providers personalized screening recommendations. The goal is to learn if using genetic testing can find men at higher risk who may benefit from cancer screening, while helping men at lower risk avoid unnecessary procedures.
This Study is Open To:
Men 55-69 years old who:
- Receive regular VA care
- Are Veteran status
This Study is NOT Open To:
Men with the following are not eligible to participate:
- Have a diagnosis of cancer
- Have had a prior biopsy, prostatectomy, or MRI
- Are confirmed to already have an (also known as a pathogenic variant) associated with cancer
What the Study Involves
Participants will be randomly assigned to one of two groups.
-
Precision Screening Group: Participants will receive a genetic risk report for cancer, personalized screening recommendations, and—if they are found to be at high genetic risk—genetic counseling. Their primary care provider will also receive the report and educational materials. High-risk men will be advised to get screening, while low-risk men will be advised not to screen.
-
Usual Care Group: Participants will receive a short brochure about shared decision-making in cancer screening.
All participants will be followed for a period of 7 years. During that time, researchers will track cancer diagnoses, tests, MRIs, genetic findings, screening preferences, and health-related quality of life.
Study Contact Information:
Name: Charles A Brunette, PhD
Phone Number: (857) 364-6324
Email: [email protected]
Locations:
Massachusetts
City: Boston RECRUITING
Facility: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Contact Info:
[email protected]
857-364-6324
Jason L Vassy, MD MPH
Prevention
Prostate cancer screening study for male US veterans age 55–69
Clinicaltrials.gov identifier:NCT05926102
Study Contact Information:
Name: Charles A Brunette, PhD
Phone Number: (857) 364-6324
Email: [email protected]