Endometrial Cancer: Stages and Subtypes

The cancer is only in the uterus.

The cancer has spread to the cervix, but has not spread to any lymph nodes. 

The cancer has spread outside of the uterus to nearby tissue; this may include the outer lining of the uterus, the ovaries, fallopian tubes, outer lining of the rectum, and nearby lymph nodes. The cancer has not spread to distant areas such as the lung, liver, bones or distant lymph nodes.

This is the most common subtype. It can vary in aggressiveness based on grade. Grade is how aggressive tumors look under the microscope. While grade 1 endometrioid adenocarcinomas have a better prognosis, grade 3 tumors are more likely to spread and recur. Low grade tumors can respond well to hormonal therapy. This subtype can be seen with Lynch syndrome and other inherited mutations linked to endometrial cancer.

This is a rare and aggressive type of endometrial cancer. There is a slightly increased risk for this subtype in people with a BRCA1 or BRCA2 mutation. This type of cancer may also be seen in people with Lynch syndrome and other inherited mutations. This type of cancer tends not to respond well to hormone therapy.

This is a rare subtype that may be more likely to occur in people with a BRCA1 mutation. This type of cancer also is less likely to be seen in people with Lynch syndrome. This type of cancer tends not to respond well to hormone therapy.

clear cell carcinoma

This is a rare and aggressive type of endometrial cancer that does not typically respond to hormone therapy. This type of cancer may also be seen in people with Lynch syndrome and other inherited mutations.

undifferentiated or dedifferentiated endometrial carcinoma

This is a rare and aggressive type of endometrial cancer.