Inherited mutations linked to endometrial cancer
The most common inherited gene mutations associated with hereditary endometrial cancer are:
- EPCAM (Lynch syndrome)
- MLH1 (Lynch syndrome)
- MSH2 (Lynch syndrome)
- MSH6 (Lynch syndrome)
- PMS2 (Lynch syndrome)
- PTEN (Cowden syndrome)
- STK11 (Peutz-Jegher syndrome)
A rare type of endometrial cancer, uterine serous carcinoma, has also been associated with BRCA mutations. However, this remains under investigation.
Panel tests look for mutations in many genes at the same time. Genetic panels may include new or less common genes. Some panels may include additional genes other than those listed above.
If you are a person who has been diagnosed with endometrial cancer, you can find peer support through the following resources:
- Register for the FORCE Message Boards to connect with others who share your situation. Once you register, you can post on the Share Your Mutation board to connect with other people who carry an inherited mutation and the Diagnosed With Cancer board to connect with other people who have been diagnosed with endometrial cancer.
- FORCE's Peer Navigation Program will match you with a volunteer who shares your mutation and situation and provide you with a free resource guide.
- Contact the FORCE impact leaders in your area to link to local support groups and other resources.
- Attend a virtual support meeting in your area.
- Read the stories from members of our community.
Other organizations that provide support for people diagnosed with ovarian cancer include:
- SHARE is a nonprofit that provides support and information for women with breast, ovarian or endometrial cancer.