Read about cancer treatment options listed by gene mutation, type of cancer and type of treatment.
Inherited mutations linked to endometrial cancer
The most common inherited gene mutations associated with hereditary endometrial cancer are:
A rare type of endometrial cancer, uterine serous carcinoma, has also been associated with mutations. However, this remains under investigation.
Panel tests look for mutations in many genes at the same time. Genetic panels may include new or less common genes. Some panels may include additional genes other than those listed above.
Expert Guidelines
Genetic counseling and testing for people diagnosed with colorectal or endometrial cancer
The National Comprehensive Cancer Network has guidelines on which people diagnosed with colorectal or endometrial cancer should undergo genetic counseling and testing. People diagnosed with colorectal cancer who have any of the following should speak with a genetics expert about genetic testing:
- A tumor test result suggesting an inherited mutation (for example, an MSI-H or tumor).
- A blood relative who tested positive for an inherited mutation linked to cancer.
- Colorectal or endometrial cancer diagnosed before age 50.
- Diagnosed with more than one cancer.
- A family history of one or more first or with any of the following types of cancer diagnosed before age 50 or two or more first or with any of the following cancers diagnosed at any age:
- colorectal
- endometrial
- ovarian
- gastric
- small bowel
- biliary tract
- pancreatic
- urothelial
- brain (usually glioblastoma)
updated: 01/22/2022
Paying For Care
Insurance coverage for genetic counseling and testing
Most health plans cover genetic counseling and testing for inherited gene mutations linked to cancer in people who meet the national guidelines. The cost of testing and your out-of-pocket charges may vary based on several factors.
People who are denied coverage for genetic testing can file an appeal (FORCE has sample appeal letters). Your healthcare provider can work with your insurance company and help you file an appeal if needed. Low cost testing may be available for $250 or less. Learn more about coverage for genetic counseling and testing here.
If you need information about finding an insurance plan, watch our video: Choosing Wisely: How to Pick Insurance Plans.
testing under the Affordable Care Act
Under the Affordable Care Act (ACA), insurance companies must pay for both genetic counseling and testing with no out-of-pocket costs for women who meet certain criteria. The ACA regulations are limited to testing for and only and do not cover genetic counseling or testing in all situations. You can learn more about testing under the ACA here.
Medicare and Medicaid coverage of genetic testing
Genetic counseling and testing is typically covered by Medicare for people already diagnosed with cancer who are in treatment or for whom test results may affect their care. Most state Medicaid programs cover genetic testing for and mutations for people who meet requirements, which vary by state. You can read more about Medicare and Medicaid coverage of genetic testing here.
Financial assistance or low cost genetic testing
JScreen is a national program based out of Emory University that provides low-cost at-home genetic counseling and testing with financial assistance available. Many laboratories offer low-cost genetic testing or financial assistance programs. Programs vary, so if you are not eligible for assistance through one lab, consider contacting other labs to see if you qualify .
- Ambry Billing and Insurance
- Color for All (Color's Family Testing Program offers $50 testing for relatives of people with a known mutation)
- Invitae Patient Assistance Program
- Quest Financial Assistance Program
- Natera Compassionate Care Program
- Myriad Cares
- Sema4 Financial Assistance
updated: 11/15/2022