Read about cancer treatment options listed by gene mutation, type of cancer and type of treatment.
Inherited mutations linked to endometrial cancer
The most common inherited gene mutations associated with hereditary endometrial cancer are:
A rare type of endometrial cancer, uterine serous carcinoma, has also been associated with mutations. However, this remains under investigation.
Panel tests look for mutations in many genes at the same time. Genetic panels may include new or less common genes. Some panels may include additional genes other than those listed above.
Genetic counseling and testing for people diagnosed with colorectal or endometrial cancer
The National Comprehensive Cancer Network has guidelines on which people diagnosed with colorectal or endometrial cancer should undergo genetic counseling and testing. People diagnosed with colorectal cancer who have any of the following should speak with a genetics expert about genetic testing:
- A tumor test result suggesting an inherited mutation (for example, an MSI-H or tumor).
- A blood relative who tested positive for an inherited mutation linked to cancer.
- Colorectal or endometrial cancer diagnosed before age 50.
- Diagnosed with more than one cancer.
- A family history of one or more first or with any of the following types of cancer diagnosed before age 50 or two or more first or with any of the following cancers diagnosed at any age:
- colorectal
- endometrial
- ovarian
- gastric
- small bowel
- biliary tract
- pancreatic
- urothelial
- brain (usually glioblastoma)
updated: 01/22/2022