Risk Management & Treatment > Cancer Treatment > By Cancer Type > Endometrial > Genes linked to hereditary endometrial cancer
Inherited mutations and endometrial cancer
Genes linked to hereditary endometrial cancer
About 1 out of 10 endometrial cancers is caused by an . The genes listed below have been linked to an increased risk for hereditary endometrial cancer. Note: this is not a complete list.
A rare and aggressive type of endometrial cancer may be linked to mutations. However, researchers are still studying this link.
Genetic testing results may affect endometrial cancer treatment
- People with endometrial cancer who test positive for an may benefit from targeted or to treat their cancer.
Genetic counseling and testing for people diagnosed with colorectal or endometrial cancer
The National Comprehensive Cancer Network has guidelines on which people diagnosed with colorectal or endometrial cancer should undergo genetic counseling and testing. People diagnosed with colorectal cancer who have any of the following should speak with a genetics expert about genetic testing:
- A tumor test result suggesting an (for example, an MSI-H or tumor).
- A blood relative who tested positive for an linked to cancer.
- Colorectal or endometrial cancer diagnosed before age 50.
- Diagnosed with more than one cancer.
- A family history of one or more first or with any of the following types of cancer diagnosed before age 50 or two or more first or with any of the following cancers diagnosed at any age:
- colorectal
- endometrial
- ovarian
- gastric
- small bowel
- biliary tract
- pancreatic
- urothelial
- brain (usually glioblastoma)
updated: 01/22/2022