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Common Biomarker Tests

Read about cancer treatment options listed by gene mutation, type of cancer and type of treatment.

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Risk Management & Treatment > Cancer Treatment > Biomarker Testing > Common Biomarker Tests

Overview Common Biomarker Tests DNA Damage Repair
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Biomarkers used for treatment selection

The following tumor biomarkers may be used to select treatment for the cancer types listed below. Speak with your doctor about other tests and treatments, which may be available. 

Cancer Treatment/s
  Breast Colorectal Endometrial Melanoma Ovarian Pancreatic

 
BRAFV600E   X   X      

Braftovi (encorafenib)
Braftovi in combination with Mektovi (binimetinib)
Cotellic (cobimetinib)
Zelboraf (vemurafenib) 
,           X   X Lynparza () 
Rubraca ()
Zejula® ()
Epidermal growth factor
receptor (EGFR) mutation testing		   X          

Erbitux (cetuximab)
Vectibix (panitumumab) 
Estrogen/Progesterone receptor
(ER/PR) expression		 X   X        

Aromatase inhibitors (AIs)
Tamoxifen
Raloxifene
 expression X X X        

Herceptin (trastuzumab)
Perjeta (pertuzumab)
Tukysa (tucatinib)
Kadcyla (ado-trastuzumab emtansine)
Enhertu(fam-trastuzumab-deruxtecan-nxki or T-DXd) 

Deficiency ()		         X    

Lynparza () 
Zejula® ()
Response (HRR) pathway mutations (, , , , , CDK12, , FANCL, , RAD51B, ,  , RAD54)             X Lynparza () 
KRAS mutation   X          

Erbitux (cetuximab)
Vectibix (panitumumab) 
MSI-H () or dMMR/MMR-D (Mismatch Repair Deficient) X X X X X X X Keytruda (pembrolizumab)
MSI-H () or dMMR/MMR-D (Mismatch Repair Deficient)   X           Opdivo (nivolumab) 
Yervoy (ipilimumab)
dMMR/MMR-D (Mismatch Repair Deficient)     X         Jemperli (dostarlimab)
NTRK fusion X X X X X X X Vitrakvi (larotrectinib)
PDL1 expression X             Tecentriq (atezolizumab)
PIK3CA X             Piqray (alpelisib),
(TMB) X X X X X X X Keytruda (pembrolizumab)
Last updated August 10, 2022