Hereditary Cancer and Genetic Testing

Risk management for people with inherited RAD51C mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for people with RAD51C mutations. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you determine the best risk management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type

Ovarian cancer prevention 

  • Consider risk-reducing salpingo-oophorectomy (removal of ovaries and fallopian tubes) between the ages of 45-50 or earlier if there is a family history of an earlier ovarian cancer.

Breast cancer screening and prevention

  • There has not been enough research to show a benefit from screening and prevention for breast cancer in women who have a RAD51C mutation. For this reason, experts recommend managing these risks based on personal and family history of cancer. 

If you are a person with a RAD51C mutation making decisions about managing your cancer risk, you can find peer support through the following resources:


Health plan coverage of screening and prevention varies, and deductibles, coinsurance and copays often apply. If you need preventive services and your insurance company denies your claim, your health care provider can help you write an appeal letter, or you can use one of our sample appeal letters. Visit our section on Insurance and Paying for Care: Screening and Prevention for more information.  


The following screening and prevention studies are open to people with a RAD51C mutation. 

Ovarian cancer

Prostate cancer

Last updated September 23, 2021