HOXB13 Gene Mutations
Information for People with an Inherited HOXB13 Mutation
What are the cancer risks for people with a mutation?
Mutations in the HOXB13 have been linked with an increased risk for cancer. There is not enough research to conclude that a HOXB13 mutation increases the risk of other cancers.
What can people with a HOXB13 mutation do?
There are guidelines for prostate cancer screening for people with HOXB13 mutations.
People with an inherited HOXB13 mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on HOXB13 Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited HOXB13 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a HOXB13 mutation.
Cancer Treatment Options
People who test positive for a HOXB13 mutation may have additional treatment or clinical trial options available to them.
Participate in Research
The prostate cancer screening and prevention studies below are enrolling people with HOXB13 mutations. To search for more studies, visit our Search and Enroll Tool.
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier: NCT03805919
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier: NCT05129605
Screening in Men at High Risk of Developing Prostate Cancer
Clinicaltrials.gov identifier: NCT05608694