All XRAYs

Study : Hereditary cancer mutations among people with multiple myeloma

Relevance: Medium

Strength of Science: Medium-Low

Most relevant for: People with multiple myeloma or who have families with multiple myeloma

People with multiple myeloma who have inherited gene mutations are more likely to have had another cancer previously and may respond better to certain treatments than people with multiple myeloma who do not have inherited mutations. Individuals with an inherited BRCA1 and BRCA2 mutation may have a slightly increased risk for multiple myeloma, but more research is needed to confirm this. (Posted 4/23/25)

Update : News from the FDA: Colorectal cancer screening and treatment

Relevance: Medium-High

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Most relevant for: People with colorectal cancer or at risk of colorectal cancer

This XRAY review is a summary of FDA colorectal cancer (CRC) updates in the last year, including education regarding CRC screening, three treatment drugs targeting different types of CRC and two colorectal screening tests. (Posted 4/16/25)

Update : Ovarian suppression may reduce breast cancer recurrence

Relevance: Medium-High

Research Timeline: Post Approval

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Most relevant for: Premenopausal women before or during early breast cancer treatment

Ovarian suppression—blocking estrogen production in the ovaries—can improve breast cancer outcomes in premenopausal women. This review provides information about ovarian suppression and describes who might benefit. (Posted 3/6/25)

Topic : Addressing the needs of young adults with breast cancer

Relevance: Medium-High

Research Timeline: Post Approval

Most relevant for: Young women with breast cancer concerned about survivorship issues

This update addresses common concerns faced by young adults with breast cancer, particularly fertility and childbearing, psychosocial health and treatment-related side effects. (Posted 2/28/25)

Study : Neighborhood affects prostate cancer risk in men of West African ancestry

Relevance: Medium-High

Strength of Science: Medium-High

Most relevant for: Men with West African ancestry

Black men of West African genetic ancestry have a much higher risk of developing prostate cancer than men of other races. The risk is even greater when they live in deprived or disadvantaged neighborhoods.  (Posted 2/26/25)

Study : Impact on sexual well-being among people with an inherited BRCA mutation

Relevance: Medium-High

Strength of Science: Medium

Most relevant for: People with an inherited mutation that increases cancer risk who are interested in sexual health

This study looked at sexual well-being in those with an inherited BRCA1 or BRCA2 mutation. Knowledge about having an inherited BRCA1 or BRCA1 mutation did not influence sexual health. However, menopause and cancer diagnosis was had a significant impact on sexual health and sexual function. (Posted 2/13/25)

Study : Risk of peritoneal cancer is low for people with an inherited BRCA mutation after surgery

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Most relevant for: People with a BRCA1 or BRCA2 mutation who have had risk-reducing surgery to remove their ovaries

The risk of peritoneal cancer is low in people with an inherited BRCA1 or BRCA2 mutation after risk-reducing ovary removal (oophorectomy). The risk was even lower when risk-reducing surgery was done at a young age and after 2005 when removal of the fallopian tubes was included in the procedure. The findings of this research support the theory that like ovarian cancer, peritoneal cancer begins in the fallopian tubes and reinforces the age recommendation for surgery. (Posted 1/23/25)

Guideline : Hereditary cancer gene guidelines expand

Relevance: Medium-High

Most relevant for: People at high risk for hereditary cancer

The National Comprehensive Cancer Network regularly updates guidelines for several types of hereditary cancer. These recommendations often change when new research is published. Recently, the NCCN expanded its guidelines to include information on hereditary prostate and gastric cancers. (Posted 1/6/25)

Este artículo está disponible en español.

Study : Lifetime cancer risks in people with an inherited mutation in CDH1

Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

Most relevant for: People with an inherited mutation in CDH1

This study looked at the lifetime risks of stomach and breast cancer in families with a known CDH1 mutation. Results from the study suggest that for some CDH1 mutation carriers lifetime stomach cancer risk is lower than previous research has shown. Additionally, study results show that the lifetime risk of breast cancer is similar to previous lifetime risk estimates in women with mutations in this gene. (Posted 12/10/24)

Este artículo está disponible en español.

Article : Life with a high-risk pancreatic and melanoma cancer mutation

Relevance: Medium

Quality of Writing: High

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Most relevant for: People with an inherited mutation in CDKN2A

One woman seeks genetic testing after her sister died of pancreatic cancer. Despite how her family’s mutation in the CDKN2A gene resulted in multiple cancer diagnoses and deaths and a suspicious finding during her own pancreatic cancer screening, Amarensia Spruitenburg shares a message of hope and gratitude. By telling her story, Amarensia highlights the impact that hereditary cancer can have on families.  (Posted 11/22/24)

Este artículo está disponible en español.