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Hereditary Cancer Info > Risk Management > Risk Management Guidelines

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Risk Management Guidelines

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

NCCN Guidelines for men and women with CDH1 mutations

Breast cancer screening for women

  • Annual mammogram and consider annual breast MRI with contrast or mammogram beginning at age 30 (or younger if family history of breast cancer before age 25)

Breast cancer risk reduction for women

  • Discussion of risk-reducing mastectomy based on family history of breast cancer

Gastric cancer risk management for women and men

  • Risk-reducing gastrectomy (removal of the stomach) is recommended between the age of 18 and 40
  • Upper endoscopy and multiple random biopsies every 6-12 months for people who do not undergo gastrectomy

Reproductive options

  • For patients of reproductive age, advise about options for prenatal diagnosis and assisted reproduction including pre-implantation genetic diagnosis. 

Risk to relatives

  • Advise about possible inherited cancer risk to relatives, options for risk assessment, and management. 
  • Recommend genetic counseling and consideration of genetic testing for at-risk relatives. 





Updated 02/03/2020

FORCE:Facing Our Risk of Cancer Empowered