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Genes Associated with Hereditary Cancers

Learn about genes and cancer, signs of hereditary cancer, genetic counseling, types of genetic tests and what results mean for you and your family.


Several studies have suggested that mutations in the RAD51C gene increase a woman’s risk of ovarian cancer. Ongoing research is studying the extent of that risk, and whether or not a RAD51C mutation increases a person’s risk for other types cancers.The PROMPT Study is a research registry enrolling people who have had panel testing in order to learn more about cancer risks associated with gene mutations like RAD51

NCCN guidelines recommend that women with an inherited mutation in RAD51C consider risk-reducing oophorectomy at age 45-50 or earlier based on family history of cancer. Other options, including  participating in detection and prevention research studies, may be available to manage risk.

Inheriting two mutated copies of RAD51C, one from each parent, has been shown to cause a rare blood disease known as Fanconi anemia in children. 

We recommend consulting with a genetics expert who can assess your personal and family history of cancer, and can help you to determine the best risk-management plan.

Updated 12/26/2017

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