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Sign Up for FORCE NewslettersInformation for People with an Inherited Mutation
People with an in have increased risk for certain cancers, including:
- breast cancer in women
- male breast cancer
- colorectal cancer
mutations have also been linked to an increased risk for and other cancers, but more research is needed to confirm this.
People with a mutation have options for screening, prevention and treatment of . There are expert guidelines and clinical trials that focus on:
- screening and early detection
- risk-reduction
- treatment
Each of these topics is outlined in more detail in the sections highlighted below.
In the News
Update: New first-line treatment option for metastatic prostate cancer
The FDA has approved Talzenna (talazoparib) with Xtandi (enzalutamide) as first-line treatments for some patients with metastatic castration-resistant prostate cancer. (Posted 10/2/23) Este artículo está disponible en español.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations.
Risk Management Options
Read about expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor testing and genetic testing can provide clues about which treatments may work best for your cancer. People with a mutation may have additional treatment or clinical trial options.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed
Clinicaltrials.gov identifier:
NCT03231891
Screening in Men at High Risk of Developing Prostate Cancer
Clinicaltrials.gov identifier:
NCT05608694
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Clinicaltrials.gov identifier:
NCT04666740
Clinicaltrials.gov identifier:
NCT04042831
Watch Our Webinar for People with Mutations
Webinar: What's new for people with ATM, CHEK2 or PALB2 mutations?