People at elevated risk for pancreatic cancer
- Known carrier of either the
BRCA2 or CDKN2A mutation
- Known carrier of any of the following mutations (
BRCA1, MLH1, MSH2, PMS2, MSH6, EPCAM, P53, PALB2, APC, or ATM) PLUS first or second degree relative affected with pancreatic cancer;
- Individual with Peutz-Jeghers Syndrome;
- Familial Pancreatic Cancer, defined as at least two affected relatives with Pancreatic Cancer, who are first degree relatives with each other, and at least one of those affected must be first degree relative to the study subject;
- Both parents affected, any age:
- Any first degree relative diagnosed with pancreatic cancer under age 50;
- Chronic Pancreatitis Syndrome, defined by either PRSS1 or SPINK1 mutations AND appropriate clinical and family history
Patients are excluded if they have:
- any medical condition that contraindicates endoscopy or biopsy
- any medical condition that contraindicates
MRI
- history of pancreatic cancer, either endocrine or exocrine
- clinical suspicion of pancreatic cancer, or any previous radiographic or histologic diagnosis of a pre-malignant finding, including IPMN (Intraductal papillary mucinous neoplasm) and PanIN (Pancreatic intraepithelial Neoplasm).
- diagnosis of dementia
- uncontrolled, current illness
- renal insufficiency with serum creatinine greater than 2.0 mg/dl
