BARD1 Gene Mutation
Information about Inherited BARD1 Mutations
What is ?
is a gene that helps repair damage to your . People who are born with changes—called mutations—in their gene have an increased risk for cancer.
What are the cancer risks for people with a mutation?
Mutations in the gene have been linked to increased risk for breast cancer in women. Currently, it is not believed that mutations increase the risk for other cancers, but research on this is continuing.
What can people with a mutation do?
There are guidelines based on the latest research for breast cancer risk management in women with a mutation.
People with a mutation who have been diagnosed with some types of cancer may qualify for specific treatments or clinical trials using targeted therapies.
If you test positive for a mutation, you should inform your close blood relatives (first-, second-, and third-degree relatives) about your test results and encourage them to speak with a genetics expert.
Each of these topics is outlined in more detail in the sections highlighted below.
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More Information for people with Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for cancer in people with inherited BARD1 mutations.
Screening & Prevention
Read about the latest expert guidelines for cancer screening and prevention for people with a BARD1 mutation.
Treatment
People who test positive for a BARD1 mutation may have additional treatment or clinical trial options available to them.
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Clinicaltrials.gov identifier: NCT04038502
New Treatment in People with Triple Negative Breast Cancer or Advanced Solid Tumors
Clinicaltrials.gov identifier: NCT06022029
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Learn More About Hereditary Cancers
Visit our section with in-depth information on screening, prevention or treatment of different types of cancer.