Get notified of page updates
Hereditary Cancer and Genetic Testing

Risk management for people with inherited mutations

The National Comprehensive Cancer Network (NCCN) provides risk management guidelines for people with  mutations. We recommend that you speak with a genetics expert, who can look at your personal and family history of cancer and can help you determine the best risk management plan. You can learn more about risk management options in our section on Screening and Risk Reduction by Cancer Type.

People with an  mutation may also qualify for clinical trials looking for more effective screening or prevention for cancer.

Breast cancer screening and prevention for women

  • Begin mammograms at age 40, or earlier based on the family history of breast cancer.
  • consider yearly with contrast beginning at age 30-35.

Experts also recommend women with an mutation have a discussion with their health care provider about the option of risk-reducing mastectomy based on their personal and family history of breast cancer.

Ovarian cancer screening and prevention

There has not been enough research to show a benefit from ovarian cancer screening and prevention in women who have an mutation. For this reason, experts recommend managing ovarian cancer risk based on family history of cancer. 

Pancreatic cancer screening

The guidelines for pancreatic cancer screening for people with an mutation include only people with a family history of pancreatic cancer.

  • For  mutation carriers with a first- or second- degree relative with pancreatic cancer consider screening beginning at age 50 or 10 years younger than the age of diagnosis of the relative. 
  • For mutation carriers who choose pancreatic cancer screening, NCCN recommends that the screening be performed in an experienced facility. Before undergoing screening, people should have a conversation with their doctor about the potential benefits, risks, costs and limitations of screening.
  • Consider annual screening with contrast-enhanced MRI/MRCP (magnetic resonance cholangiopancreatography) and/or EUS (endoscopic ).
  • Consider enrolling in a research study looking at methods to screen for cancer, or agents to lower risk. 

Prostate cancer screening

  • Beginning at age 40, men with an inherited mutation should have a conversation with their doctor about the benefits, limitations and costs for cancer screening.
  • For men who choose screening, the expert panel recommends annual  testing and digital rectal exam.

Other cancer screening and prevention

There has not been enough research to show a benefit from screening and prevention for other cancers in people who have an mutation. For this reason, experts recommend managing these risks based on family history of cancer.  Cancer screening and prevention research studies may be available for people with mutations. 

Last updated September 13, 2022

Get Support
Get Support

FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022

Paying For Care
Paying For Care

Health plan coverage of screening and prevention varies, and deductibles, coinsurance and copays often apply. If you need preventive services and your insurance company denies your claim, your health care provider can help you write an appeal letter, or you can use one of our sample appeal letters. If you need information about finding an insurance plan, watch our video: Choosing Wisely: How to Pick Insurance Plans.

Visit our section on Insurance and Paying for Care: Screening and Prevention for more information. 

updated: 11/15/2022

Open Clinical Trials
Open Clinical Trials

The following are risk-management studies enrolling people with inherited mutations. Check study listings or contact the study team to see if you are eligible. 

Multiple cancers


  • NCT03805919: Men at High Genetic Risk for  Cancer. This is a  cancer screening study using  in high risk men. This study is open to men with , , , , , HOXB13, , , ,  and other inherited mutations.
  • NCT05129605: Cancer Genetic Risk Evaluation and Screening Study (PROGRESS).  This study will look at how well  MRI works as a screening tool for men at high risk for cancer. This study is open to men with inherited mutations in , , , , , , HOXB13, , , , , , , , , and other genes. 

Ovarian cancer

Pancreatic cancer

Additional risk-management clinical trials for people with inherited mutations may be found here.

updated: 09/11/2022