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ATM: Options for Managing Cancer Risk

People with an ATM mutation have options for managing their cancer risk. Learn about the screening and prevention guidelines. Stay up to date by signing up for our community newsletter.

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ATM: The Basics ATM Mutations: Cancer Risks ATM: Options for Managing Cancer Risk ATM: Options for Cancer Treatment ATM: Other Considerations

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Risk Management for People with Inherited Mutations

People with mutations have options for managing their increased cancer risk. Experts at the National Comprehensive Cancer Network (NCCN) created guidelines for people with an mutation to manage their cancer risk. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your risk.

NCCN recommends that all people with an inherited mutation receive education on the signs and symptoms of ATM-related cancers. NCCN guidelines for specific cancers are listed below.

Breast cancer

Pancreatic cancer

Ovarian and fallopian tube cancer

Prostate cancer

Other cancers

People with an mutation may also qualify for clinical trials looking for more effective screening, prevention or interception of cancer.

Breast cancer risk management

Beginning Age	Recommendation	Additional Information
25	Learn to be aware of changes in your breasts.	Based on NCCN guidelines for women of average risk.
25	Breast exam by doctor every 1-3 years.	Based on NCCN guidelines for women of average risk.
30-35	Discuss the benefits, risks and costs of yearly breast MRI with and without contrast with your doctor.
40 (or earlier based on family history of breast cancer)	Yearly mammogram.
No set age	More research is needed to show whether people with inherited ATM mutations benefit from risk-reducing mastectomy. Discuss with your doctor about the option of risk-reducing mastectomy based on your personal and family history of cancer.	Risk-reducing mastectomy lowers breast cancer risk by 90%, but has not been shown to improve survival. Even after double mastectomy, some breast tissue, and therefore cancer risk remains.
No set age	Discuss the benefits, risks and costs of medications to lower the risk for breast cancer with your doctor.	Tamoxifen or other estrogen-blocking drugs may lower breast cancer risk. Medications or vaccines are being studied in clinical trials.
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, Prostate, vs. 3 2025.

Pancreatic cancer risk management

Types of pancreatic cancer screening tests

There are two types of tests that are used to screen for pancreatic cancer in high-risk people.

MRCP (Contrast-enhanced magnetic resonance cholangiopancreatography) is a special type of imaging that looks closely at the pancreas, liver, gallbladder, bile duct and pancreatic duct to find abnormalities such as cancer.
EUS (Endoscopic ) involves passing a tiny scope with an attached probe down the esophagus to the stomach. This allows doctors to look closely at the pancreas.

Researchers are testing new approaches to pancreatic cancer screening and prevention through clinical trials.

Pancreatic Cancer Screening Study (CAPS5)

LEARN MORE

Pancreatic cancer guidelines

Beginning Age	Family History	Recommendation
50 (or earlier based on the youngest case of pancreatic cancer in the family)	For ATM mutation carriers regardless of family history. Note: this is a change from 2024 guidelines.	Discuss the benefits, risks, costs and limitations of screening with your doctor. Screening should include annual MRCP or EUS or both. Screening should be performed in a facility with experience in screening high-risk patients for pancreatic cancer.
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, v. 3 2025.

Ovarian and cancer risk management

Beginning Age	Recommendation	Additional Information
No set age	Become aware of ovarian and primary peritoneal cancer symptoms. Report to any symptoms that persist for several weeks and are a change from normal to your doctor. Routine ovarian cancer screening using transvaginal ultrasound and a CA-125 blood test has not shown benefit and is not recommended.	Symptoms of ovarian cancer include: pelvic or abdominal pain bloating or distended belly difficulty eating feeling full sooner than normal increased urination or pressure to urinate
No set age	More research is needed to show whether people with inherited ATM mutations benefit from risk-reducing surgery to remove their ovaries and fallopian tubes. Currently, experts recommend that you have a discussion with your doctor about the option of risk-reducing surgery based on your family history of cancer.
Before age 50	Researchers are studying whether the removal of the fallopian tubes only (salpingectomy), while delaying oophorectomy until closer to the age of natural menopause is a safe option for lowering risk in people who are not ready to remove their ovaries. If you are interested in this approach, talk with your doctor about the benefits and risks, and consider enrolling in a research study.	At this time, it is not known if salpingectomy lowers the risk for ovarian cancer in high-risk people. Salpingectomy, followed by delayed oophorectomy requires two separate surgeries.
No set age	Oral contraceptives (birth control pills) have been shown to lower the risk for ovarian cancer in people with BRCA1 mutations. Have a discussion with your doctor about the benefits and risks of oral contraceptives for lowering ovarian cancer risk.	Research on the affect of oral contraceptives on breast cancer risk has been mixed.
Source: NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, Prostate, vs. 3 2025.

cancer risk management

Beginning Age	Recommendation
40	Have a conversation with your doctor about the potential benefits, risks, costs and limitations of screening for prostate cancer. If you choose to have screening, the guidelines recommend a Prostate Specific Antigen (PSA) test. Many experts also recommend a digital rectal examination that allows your doctor to feel for abnormalities in the prostate.
Source: NCCN Guidelines: Prostate Cancer Early Detection; v. 1, 2025.

Other cancers

There has not been enough research to show a benefit from screening and prevention for other cancers in people who have an mutation. For this reason, experts recommend managing these risks based on your family history. Cancer screening and prevention research studies may be available.