Study: Insulin resistance linked to differences in breast cancer survival between Black and White women
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This study is about:
How blood sugar and insulin levels affect the risk of death from breast cancer in Black women compared to White women.
Why is this study important?
Black women are more likely to die from breast cancer compared to White women. More Black women have a condition called insulin resistance than White women. Insulin resistance (sometimes called pre-diabetes), is when cells do not respond well to insulin.
This study looks at whether insulin resistance may be one of the reasons that Black women are more likely to die from breast cancer. Insulin resistance is treatable, so knowing whether it affects breast outcomes could help researchers find ways to improve survival for Black women.
What is insulin and insulin resistance?
Insulin is a hormone made by the pancreas that helps sugar in your blood get into cells where it is used for energy. Blood sugar levels rise after you eat. In response, your pancreas releases insulin into the blood. Insulin then lowers blood sugar to keep it in a normal range.
Sometimes cells become less responsive to insulin or insulin resistant. When this happens, the pancreas keeps making more insulin to try to get sugar into cells. Eventually, the pancreas cannot keep up and blood sugar rises.
What causes insulin resistance?
Insulin resistance can be due to many things. Genetics, age and certain lifestyle factors may affect your risk for insulin resistance.
Insulin resistance risk factors include:
- age 45 or older
- a close relative (parent, brother or sister) with diabetes
- ethnicity (African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander American)
- a personal history of gestational diabetes or stroke
- physical inactivity
- other health conditions such as high blood pressure, abnormal cholesterol levels, obesity or hormonal conditions such as polycystic ovary syndrome (PCOS)
You cannot tell if you have insulin resistance by how you feel. A test that checks your blood sugar levels is used to diagnosis insulin resistance.
Insulin resistance and cancer
Insulin resistance is linked to increased risk for many types of cancers. However, experts do not know why insulin resistance increases cancer risk. In addition to controlling blood sugar, insulin may cause cancer cells to grow and divide. It may also cause cancer cells to ignore signals to stop growing and die. Cancer cells often have high levels of insulin receptors, which may increase risk of a cancer growing. Anyone of these or some unknown factor may be the link between insulin and cancer.
This study looked at 87 Black women and 428 White women newly diagnosed with breast cancer. They also looked at:
- insulin resistance
- breast cancer prognosis
The researchers used a statistical test to see if insulin resistance may be a reason that Black women have a worse prognosis than White women. They found that:
- Insulin resistance is linked to worse prognosis in Black women with breast cancer.
Many factors may cause differences in breast cancer survival between Black and White women. These results suggest that insulin resistance may be one of these factors. While the data shows a link between insulin resistance and worse prognosis, it does not show whether insulin resistance causes Black women to have a worse breast cancer outcomes compared to White women. Studies to see if lowering insulin levels improves breast cancer outcomes in Black women are needed to confirm these findings.
This study found that insulin resistance is one factor that may contribute to worse breast cancer prognosis in Black women compared to White women. Because insulin resistance can be treated with lifestyle changes or medication, it will be important to study whether lowering insulin levels will improve breast cancer survival for Black women.
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Gallagher EJ, Fei K, Feldman SM,et al., Insulin resistance contributes to racial disparities in breast cancer prognosis in US women. 2020. Breast Cancer Research. 22: 40.
FORCE receives funding from industry sponsors, including companies that manufacture cancer drugs, tests and devices. All XRAYS articles are written independently of any sponsor and are reviewed by members of our Scientific Advisory Board prior to publication to assure scientific integrity.
IN-DEPTH REVIEW OF RESEARCH
Black women are more likely to die from breast cancer compared to White women regardless of the of breast cancer at diagnosis. More Black women have a metabolic condition called insulin resistance than White women. This study looked at whether insulin resistance might contribute to the association between race and breast cancer outcomes. This study also looked to see if proteins on breast cancer cells that respond to insulin differed between breast cancers from Black and White women.
Researchers of this study wanted to know:
Whether insulin resistance may be one of the factors that contributes to the association between race and breast cancer prognosis.
Populations looked at in this study:
This study looked at 515 women newly diagnosed with invasive breast cancer. Participants were recruited from ten US hospital sites in New York, New Jersey, Connecticut, Maryland and Michigan.
A total of 87 Black women and 428 White women enrolled in the study. Clinical data recorded for participants included self-reported smoking and alcohol use, diet and physical activity, education, income and insurance.
At the study visit, participants had height and weight recorded which was used to calculate body mass index (BMI). Blood pressure was also recorded.
Following an overnight fast (minimum of 8 hours), a blood test was used to measure blood glucose, insulin, C-peptide, total cholesterol as well as high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides. Insulin resistance was calculated from fasting glucose and fasting insulin levels.
The study used the Nottingham prognostic index (NPI) to determine prognosis. The NPI is a number calculated following surgery for breast cancer. The NPI score is based on the size of the tumor, the number of positive and the grade of the tumor.
The researchers also looked at the levels of insulin receptor and insulin-like receptor in participants tumors.
The researchers used additional statistical modeling test to see if insulin resistance may be one factor that influences poor prognosis in Black women.
- Race was associated with prognosis.
- 28 percent of Black women (24 of 87) had a poor NPI prognostic score
- 15 percent of White women (63 of 428) had a poor NPI prognostic score.
- Race was associated with insulin resistance.
- 40 percent of Black women (35 of 87) had insulin resistance.
- 20 percent of While women (85 of 428) had insulin resistance.
- Statistical modeling showed that insulin resistance mediated the association between Black race and poor prognosis.
- Insulin receptor expression was higher in breast tumors from Black women compared to White women.
- The ratio of insulin receptor to insulin-like growth factor receptor 1 was higher in breast tumors from Black women compared to White women and was associated with a higher NPI score.
Limitations of this study included the fact that the researchers were not able to determine how long patients had insulin resistance prior to their breast cancer diagnosis. The researchers also had missing data for some patients on other breast cancer risk factors such as reproductive history.
In this study, the obesity as defined by BMI was lower in participants than would be expected for the general US population. This could be due to the fact that study participants largely resided in the east coast states of New York, New Jersey, Connecticut and Maryland. In these states, self-reported obesity by BMI is between 25 and 30 percent compared to 35 and 57 percent for women in the US. Although the exact causes of this difference in obesity are not all known, they likely reflect differences in social and economic advantage..
Importantly the authors acknowledge that insulin resistance may be one of a number of factors that contribute to the difference between breast cancer prognosis in Black women compare to White women.
Many complex factors likely contribute to the observation that Black women are more likely to die from breast cancer compared to White women. Data suggests that Black women are more likely to be treated differently than White women following a breast cancer diagnosis. Other barriers include include access to care, screening and treatment as well as biologic and genetic differences in tumors. In addition, research supports the link between insulin resistance and risk for many types of cancer including breast cancer. This research looked at one of the many factors that may mediate disparities in breast cancer outcomes between Black and White women.
This research looked at insulin resistance and showed that it may be one factor that affects why Black women are more likely to die of breast cancer than White women. This may be due to the effects of insulin on tumor insulin receptors. It will be important to design future studies to look at whether lowering insulin levels improves breast cancer survival for Black women.
The American Cancer Society (ACS) guidelines on exercise, nutrition and weight for cancer prevention recommend the following:
Diet and nutrition
- Follow a healthy eating pattern, including:
- foods that are high in nutrients in amounts that help you get to and stay at a healthy body weight.
- a variety of vegetables, fiber-rich legumes (beans and peas), and whole fruits in a variety of colors. Consume at least 2½ to 3 cups of vegetables and 1½ to 2 cups of fruit each day, depending on your calorie requirements.
- whole grains rather than refined grains. At least half of the grains you eat should be whole grains.
- A healthy eating pattern that limits or does not include:
- red and processed meats.
- sugar-sweetened beverages.
- highly processed foods and refined grain products.
- It is best not to drink alcohol. People who choose to drink alcohol should:
- have no more than 1 drink per day (women) or 2 drinks per day (men).
- Exercise regularly.
- Adults should get at least 150 minutes of moderate-intensity activity (equal to a brisk walk) or 75 minutes of vigorous activity (heart rate is increased, breathing is faster and you are sweating) each week, preferably spread throughout the week.
- Physical activity has been shown to lower the risk of several types of cancer, including breast, endometrial, and colon. It also reduces the risk of other serious diseases such as diabetes and heart disease.
- Achieve and keep a healthy weight.
- Being overweight or obese is a risk factor for many cancers, including breast, colon, endometrial and pancreatic. You can control your weight through regular exercise and healthy eating.
Other experts, including the following, also provide guidelines for exercise, nutrition and health:
- The Academy of Nutrition and Dietetics
- The United States Office of Disease Prevention and Health Promotion
- The American Institute for Cancer Research
- What are the signs of insulin resistance?
- Do I have risk factors that would increase my chance of developing insulin resistance?
- Should I be tested for insulin resistance?
- If I have insulin resistance (or become insulin resistant), how does that affect my breast cancer prognosis?
- If I have insulin resistance, how can that be treated?
The following clinical research studies focus on addressing in cancer.
- NCT04336397: Stool to Improve Colorectal Cancer Screening Among Alaska Native People. The goal is to determine the acceptability of a stool test to detect colorectal cancer within the Alaska tribal healthcare system.
- NCT04476654: Improving Uptake of Genetic Cancer Risk Assessment in African American Women-Video. This study looks at the usefulness of intervention with a culturally-tailored video to improve uptake of genetic counseling in Black women who are at increased risk of .
- NCT04450264: Increasing African Immigrant Women's Participation in Breast Cancer Screening (AIBCS). The study will look at barriers and facilitators to breast cancer screening among African-born immigrants, and adapt and test the Witness Project breast cancer education program to address breast screening disparities in this population.
- NCT04854304: Abbreviate or FAST Breast for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts. This study is looking at how effectively a FAST breast can successfully detect breast cancer in Black women with dense breasts.
- NCT03640208: Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans. This research will study a community-based intervention to educate and overcome barriers to screening among African Americans who are 45 years or older with no personal or family history of colorectal cancer or inflammatory bowel disease.
- NCT04392050: A Community-Based Educational Intervention to Improve Colorectal Cancer Screening. This study will look at what makes it easy or difficult for underserved populations to have colorectal cancer screenings, with a focus on African American, Latinx and Asian people.
- NCT03550885: Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk. This effort will look at how bile secretion into the intestine selects for bacteria that produce tumor-promoting molecules in African Americans with an increased risk for colorectal cancer.
The following are studies focused on nutrition and cancer prevention.
- NCT04125914: HEALTH4Families: Optimizing a Weight Management and Health Behavior Intervention for BRCA+ and Families. This trial studies how well weight management and health behavior intervention lower the risk of cancer in patients with hereditary breast and ovarian cancer mutations or mutations.
- Energetics and Lifestyle in Inherited Syndromes (ELLIE’s Study). ELLIE’s Project is designed to look at factors, such as weight, Body Mass Index, metabolism, dietary habits and activity levels that may affect cancer risk in people with inherited mutations linked to cancer.
- NCT05094466: Parent and Family Obesity Intervention in Reducing Obesity Risk in Racial Ethnic Minority Families. This compares the effects of parent/caregiver-focused programs to family-focused programs in reducing obesity risk in racial ethnic minority families.
- NCT04374747: Fruit and Vegetable Intervention in Lactating Women to Reduce Breast Cancer Risk. This trial is for nursing mothers. This study will look to see if eating at least 8 to 10 daily servings of fruits and vegetables reduces breast cancer biomarkers.
- NCT03448003: Comprehensive Lifestyle Change To Prevent Breast Cancer. This trial looks at how well lifestyle changes work to prevent breast cancer. Premenopausal women 18 years and older with intact breast and ovaries are eligible.
- NCT03779867: Acute Exercise Intervention in Reducing Breast Cancer Risk in Healthy Participants (ACE). This trial at the Fred Hutchinson Cancer Research Center in Seattle studies how well acute exercise in healthy participants reduces the risk of breast cancer in healthy participants.
- NCT03550885: Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colorectal Cancer Risk. This study investigates colorectal cancer risk in African Americans who consume high amounts of taurine and saturated fat (e.g., animal-based diets) compared with those who consume low amounts of taurine and saturated fat (e.g., plant-based diets).
- NCT04192071: Virtual Human Delivered Nutrition Module for Colorectal Cancer Prevention. This study will develop and test an interactive nutrition module for use with colorectal cancer screening to learn which messages and graphics promote understanding of cancer risk and promote screening.
You can find a registered dietician in your area using the search tool from the Academy of Nutrition and Dietetics.
Who covered this study?
Insulin resistance may contribute to worse prognosis in Black women with breast cancer This article rates 4.0 out of 5 stars
Insulin resistance contributes to racial disparities in breast cancer prognosis in US women This article rates 4.0 out of 5 stars
Med Page Today
Does insulin resistance worsen breast cancer prognosis in Black women? This article rates 3.0 out of 5 stars