Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving.
Genetic testing can find mutations in a gene called CDH1. Inherited mutations in the
CDH1 gene are associated with hereditary diffuse gastric cancer syndrome, which is known to increase the risk of certain cancers, including:
People with mutations in
CDH1 tend to develop cancer at a younger age than people with average cancer risk. Ongoing research may help researchers better understand cancer risk for people with a CDH1 mutation.The PROMPT Study is a research registry enrolling people who have had panel testing in order to learn more about cancer risks associated with gene mutations like CDH1.
National guidelines for managing cancer risk in people with
CDH1 mutations recommend:
Other options, including participating in detection and prevention research studies, may be available to manage risk.
A genetics expert can look at your personal and family medical history and see if it is consistent with hereditary diffuse gastric cancer syndrome syndrome and order testing if appropriate.