Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving.
BRIP1 (stands for BRCA1 Interacting Protein C-terminal Helicase 1) is a gene that works with
BRCA1 to repair damaged DNA. Although “BRIP1” includes a reference to BRCA1, the two genes are different; people with BRIP1 mutations may or may not have BRCA1 mutations.
Women who inherit one mutated copy of
BRIP1 are at an increased risk of ovarian cancer. Research on the risk for other cancers and extent of each cancer risk for people with mutations in BRIP1 is ongoing.
NCCN guidelines recommend that women with an inherited mutation in
BRIP1 consider risk-reducing oophorectomy at age 45-50. We recommend consulting with a genetics expert who can assess your personal and family history of cancer, and can help you to determine the best risk-management plan.
Inheriting two mutated copies of
BRIP1, one from each parent, causes a rare blood disease known as Fanconi anemia in children.