Breast Cancer: Early Detection

Breast exams, breast awareness and breast cancer symptoms

Breast exams involve feeling the breast tissue for lumps or other changes that might be cancer.

• During a clinical breast exam (CBE) the doctor or nurse carefully feels the entire breast to find lumps or other abnormal changes.
• A breast self exam (BSE) involves a person checking their own breasts on a monthly basis to look for abnormalities. BSE is no longer recommended for women by some organizations, but others continue to recommend BSE since many cancers are initially found this way. Experts recommend training high risk men to perform BSE.  
• Breast awareness is a term that highlights the importance of people knowing what normal breast tissue should feel like and reporting any changes or abnormalities in their breasts to their doctors. Similar to a breast self exam, breast awareness requires people to check their breasts at regular intervals. Ask your doctor to explain what you should look for and when to report changes. 
• Some of the symptoms of breast cancer are listed below. Importantly, these symptoms do not mean you definitely have cancer. Also, many breast cancers don't cause any symptoms. Report any of the following to your doctor:
  • a lump or abnormal mass in the the breast
  • breast swelling 
  • dimpling or puckering of the skin of the breast
  • changes in the nipple (turning inward, red, thickened, dry and flaking
  • nipple discharge (other than milk)

  • swelling of the lymph nodes in the armpits or collar bone area

Mammograms 

Mammograms use xrays to look at the breast tissue. Mammograms, like other xrays, expose people to a small amount of radiation. They are considered safe for most women, however experts recommend that women who may be sensitive to radiation should avoid mammograms and use breast MRIs instead. This group includes women under the age of 30 and women with certain inherited mutations, such as TP53. Mammography is the most commonly used screening tool to detect breast cancer. Mammograms find cancers in women of all ages, however, mammograms are less effective for women with dense breast tissue. You can read more about breast density and how it's measured and reported in the article on the right. For women with dense breasts, ultrasound or MRI may find cancers that were not seen with mammograms.

3D mammograms

Breast tomosynthesis, also known as 3-D mammography, uses xrays to take a series of images that give a layer-by-layer, 3-dimensional picture of the breast. Because of this, 3D mammograms may find cancers earlier than traditional mammograms. They are also less likely to give a "false positive" result, when a person is called back for an abnormality that turns out to be cancer. The radiation exposure  from tomosynthesis is small, and does not increase the risk for breast cancer.

Breast MRI

Breast Magnetic Resonance Imaging (MRI) is an imaging method that uses magnetic fields rather than xrays to produce a detailed picture of the breasts. MRI is sensitive and may pick up an abnormality not seen by other imaging tools. For this reason, MRI is recommended for women at high risk for breast cancer. There is also a greater chance for MRI to find changes that need a biopsy, but end up being benign (not cancer). These are known as "false positive" results. 

MRI exams that look for cancer require the injection of a contrast agent called gadolinium. The contrast helps doctors spot breast abnormalities more easily. There is some concern that with repeated use during yearly breast screenings, gadolinium could build up in the brain. Researchers are studying whether this buildup is harmful to some people. At the moment, most experts have concluded that the benefit of using contrast agents for breast MRIs in high risk women outweighs the small possible risks. Newer agents are available that may cause less buildup in the brain. It is important that you talk with your doctor about the risks and benefits of annual MRI with gadolinium contrast. 

Ultrasound

Ultrasound uses sound waves to image the breast. Ultrasound may be used to find cancers in women with dense breasts, which can hide cancer on a mammogram. Ultrasound is painless, ses no radiation and is widely available. Ultrasound is less sensitive than breast MRI and therefore is not usually used for screening high risk women who already receive yearly MRIs.  

Breast screening guidelines

Experts have different recommendations for screening based on a person's risk for breast cancer. Breast cancer screening guidelines are different for people at high risk and average risk. Note that when we use the term "men" and "males," we are referring to people assigned male at birth. Note that when we use the term "women" and "females," we are referring to people assigned female at birth. 

Screening for high-risk women

The National Comprehensive Cancer Network (NCCN), is an organization of cancer experts that creates guidelines on cancer care and updates them yearly. They create separate guidelines for women at increased risk for breast cancer due to inherited mutations or other risk factors. Screening guidelines for high risk women usually includes a combination of breast exams, 3D mammograms and breast MRIs, often beginning at age 25. You can find information on screening guidelines for specific gene mutations linked to breast cancer here.