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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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21 through 30 of 33

Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Genetic counseling by phone or face-to-face

Most relevant for: People referred to a genetic counselor or those considering genetic testing

Results presented at the 2017 American Psychological Association’s annual meeting showed genetic counseling by telephone is as “safe and effective” in long-term psychological and social outcomes compared to traditional in-person counseling for women at risk for hereditary breast and ovarian cancer. This presentation is an update on research published in 2014. (11/29/17)

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Relevance: Medium-High

Quality of Writing: High

Article : Preimplantation genetic diagnosis and hereditary cancer

Most relevant for: people with an inherited mutation linked to cancer risk

Andrew Joseph’s piece for STAT, “A baby with a disease gene or no baby at all: Genetic testing of embryos creates an ethical morass,” focuses on  preimplantation genetic diagnosis (PGD) and the emerging ethical issue in the field of reproductive medicine: What to do when patients seeking to get pregnant select embryos with DNA that could lead to a disease or a disability.  (11/8/17)

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Relevance: Medium-High

Quality of Writing: High

Article : Parents face challenges when deciding the best time to tell children that they may be at high risk for cancer

Most relevant for: Parents who have an inherited gene mutation

When certain types of cancers run in families, genetic testing can determine whether the cause is hereditary. Genetic testing can help family members understand their cancer risk and make medical decisions to stay healthy. A test result can provide significant insight, but it also creates challenges for parents, because gene mutations that cause hereditary cancers can be passed from mothers and fathers to sons and daughters. People with these mutations must make difficult decisions about when to tell their children that they too may have inherited the mutation. (8/22/2017)

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Relevance: High

Quality of Writing: High

Article : FDA busts myths of preventing and treating cancer by eating apricot kernels, herbs, and other ingredients

Most relevant for: People diagnosed with or concerned about their risk for cancer

Maggie Fox (NBC News) writes about a new FDA report that warns of 14 "fraudulent” cancer products claiming to either cure or treat cancer (1). The companies that sell these products claim that many of them also prevent cancer, but are they safe or effective? (6/26/17)

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Relevance: High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Does scalp cooling help prevent hair loss after chemotherapy?

Most relevant for: Patient undergoing chemotherapy

Hair loss is one of the most recognized and distressing side effects of some chemotherapies. Two studies looked at the use of scalp cooling therapy to help reduce hair loss after chemotherapy for early-stage breast cancer. (5/15/17) 

Update: Based on data from clinical trials, the FDA approved Dignicap scalp cooling device for treatment in patients diagnosed with solid tumors who are receiving chemotherapy. 

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Relevance: Medium

Quality of Writing: High

Article : A cancer patient’s tumor is genetically profiled—how does that info help treatment?

Most relevant for: People diagnosed with advanced cancer

Jessica Wapner's Scientific American article explores the difficulties of making the vast amount of information acquired from tumor gene tests useful to patients and physicians. (9/20/16). Update: THIS INFORMATION HAS BEEN UPDATED. In late 2017, the FDA approved two separate tumor profiling tests to help guide treatment choices. The FoundationOne CDx (F1CDx) genomic test has been approved to test for 15 different targeted therapies used to treat five types of cancer, including ovarian, colorectal, lung, breast and melanoma. The FDA also approved the MSK-IMPACT and developed for use by Memorial Sloan Kettering Cancer Center (MSKCC) to scan tumor samples for 468 different cancer-associated mutations or alterations.

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Relevance: Medium-High

Strength of Science: Medium-High

Study : Financial burden affects quality of life of cancer survivors

Most relevant for: People diagnosed with cancer

Cancer-related financial burden can keep survivors from getting the care that they need, yet how this burden affects mental and physical health is still unknown. A study found that almost one-third of cancer survivors report having financial burden; those most likely to be affected were under age 65, female, members of racial or ethnic minority groups, and people who lack access to adequate insurance. (5/17/16)

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Relevance: Medium-High

Strength of Science: Medium-High

Study : Factors that affect the ability to work in people with metastatic cancer

Most relevant for: People living with metastatic cancer

Some patients who live with metastatic cancer either want or need to continue working while coping with symptoms of their disease and treatment. A recent study that looked at over 600 people with metastatic breast, prostate, colon, or lung cancer found that about one-third of them continue working full or part time. People most likely to continue working were those undergoing hormonal treatment and those with less severe symptoms or side effects from treatment. (4/12/16)

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : What are the genetics underlying 12 different cancer types?

Most relevant for: People diagnosed with cancer

As gene sequencing has become more affordable, researchers and health care providers are now looking for mutations in many genes beyond BRCA1, BRCA2 and others that are associated with known hereditary cancer syndromes. By sequencing thousands of genes rather than just one or two, researchers can better understand which inherited mutations affect cancer risk. In this study, researchers sequenced thousands of genes in patients with one of 12 cancers, including breast, and catalogued which gene mutations are most commonly found in each cancer. (03/01/16)

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Human Research

Study : How many children with cancer have mutations in genes that increase cancer risk?

Most relevant for: Survivors of childhood cancer and people with a family history of relatives diagnosed with childhood cancers

Many genes are associated with increased cancer risk in adults, but it is unclear how common these mutations are in children with cancer. This study found that about 9% of children with cancer carry mutations in a gene that is known to increase cancer risk. Over half of the mutations were in the TP53 gene, which is associated with increased cancer risk at a young age and increased risk of breast cancer in adults. (12/15/2015)

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