Education > XRAY > Colorectal Cancer

FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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1 through 10 of 12

Relevance: High

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Strength of Science: Medium-High

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Research Timeline: Post Approval

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Study : Genetic testing for inherited mutations may be helpful for all people with advanced or metastatic cancer

Most relevant for: People with metastatic or recurrent cancer

In a study of nearly 12,000 cancer patients with a variety of cancers, eight percent of participants with metastatic cancer had an inherited mutation in a cancer gene that qualified them for a targeted treatment approved by the FDA or for participation in a clinical trial. The majority of people with metastatic cancer were unaware that they had an inherited mutation, and had not receive gene-directed treatment to which their tumor may have responded. The study authors suggest that genetic testing for inherited mutations may be warranted for all patients with advanced or metastatic cancer. (posted 9/30/21)

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Genetic testing for inherited mutations may be helpful for all people with advanced or metastatic cancer

Relevance: Medium-Low

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Research Timeline: Human Research

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Update : Liquid biopsies for cancer screening, monitoring and treatment

Most relevant for: People considering a liquid biopsy to screen for cancer

Could a simple blood test change cancer detection, treatment and monitoring? Several companies are offering a type of blood test known as a liquid biopsy to detect multiple cancers at their earliest stages, monitor response to treatment and help choose the best treatment. Although progress has been made using liquid biopsies to treat cancer, these tests have not yet been shown to detect cancer early enough to save lives. (posted 9/29/21)

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Liquid biopsies for cancer screening, monitoring and treatment

Relevance: Medium

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Strength of Science: Medium-High

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Research Timeline: Post Approval

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Study : Do sugared beverages increase the risk of early-onset colorectal cancer?

Most relevant for: Healthy people with an average colorectal cancer risk

A study of female nurses in the U.S. suggests that a high intake of sugar-sweetened beverages may increase the risk of colorectal cancer before age 50. However, researchers saw few early-onset colorectal cancer cases which limited the findings. (posted 9/21/21)

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Do sugared beverages increase the risk of early-onset colorectal cancer?

Relevance: High

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Strength of Science: High

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Research Timeline: Post Approval

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Study : Cancer risks of people with inherited PALB2 mutations

Most relevant for: people with inherited PALB2 mutations

In the largest study of people with inherited PALB2 mutations to date, the gene was linked to increased lifetime risk of breast cancer in women and men, ovarian and pancreatic cancer but not prostate or colorectal cancer. (posted 7/1/21)

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Cancer risks of people with inherited PALB2 mutations

Relevance: High

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Strength of Science: High

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Research Timeline: Post Approval

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Study : Daily high-dose aspirin taken for at least 2 years reduces the risk of colorectal cancer but not other cancers in people with Lynch syndrome

Most relevant for: People with Lynch syndrome

Research has shown that daily aspirin use can reduce the risk of colon and other cancers. The Cancer Prevention Program 2 (CaPP2) study looked at the effect of daily aspirin in patients with Lynch syndrome. After 10 years of follow-up, the results showed that taking daily aspirin for two years reduced the frequency of colon cancer in patients with Lynch syndrome, and importantly, did not result in an increase in side-effects or complications. No benefit was seen for other Lynch syndrome-related cancers, including endometrial cancer. (5/17/21)

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Daily high-dose aspirin taken for at least 2 years reduces the risk of colorectal cancer but not other cancers in people with Lynch syndrome

Relevance: Medium-High

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Strength of Science: High

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Update : Cancer disparities: Colorectal cancer in African Americans

Most relevant for: African Americans concerned about colorectal cancer

The American Association for Cancer Research (AACR) released a 2020 report about cancer disparities among racial and ethnic groups in the United States. In this XRAY review, we highlight data from the report about the burden of colorectal cancer in African Americans, who have the highest rates of diagnosis and death related to the disease among all racial and ethnic groups. (Posted 4/27/21)

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Cancer disparities: Colorectal cancer in African Americans

Relevance: High

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Strength of Science: Medium-High

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Research Timeline: Post Approval

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Study : Expanded access to Medicaid coverage under the Affordable Care Act is linked to reduced cancer mortality

Most relevant for: People with breast, colorectal or lung cancer.

In 2014 the Affordable Care Act expanded Medicaid coverage. How did this affect healthcare for cancer patients? This study shows that deaths from breast, colorectal and lung cancer are lower in states that chose to expand Medicaid compared to states that did not. Early diagnosis was linked to lower death rates. This suggests that increased healthcare access may lead to earlier cancer detection and better outcomes, including lower mortality. (3/31/2021)

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Expanded access to Medicaid coverage under the Affordable Care Act is linked to reduced cancer mortality

Relevance: Medium-High

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Strength of Science: Medium-High

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Research Timeline: Post Approval

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Study : Body Mass Index (BMI) may affect how well aspirin use protects against colorectal and ovarian cancer

Most relevant for: People concerned about their risk of colorectal or ovarian cancer.

This study looked at the impact of daily aspirin use for lowering the risk for multiple types of cancers and whether this risk reduction can be modified by cancer risk factors such as obesity, smoking, physical inactivity or a family history of cancer. (3/19/21)

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Body Mass Index (BMI) may affect how well aspirin use protects against colorectal and ovarian cancer

Relevance: Medium-High

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Research Timeline: Post Approval

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Guideline : COVID vaccines for people with cancer

Most relevant for: Cancer patients, their family and caregivers

Should cancer patients get a COVID vaccine? The National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology (ASCO) provide guidance for people with cancer. These experts recommend that most cancer patients get vaccinated as soon as the vaccine is offered (unless they are allergic to a vaccine component). Cancer patients who have had recent surgery may delay vaccination a few days after surgery. Those with a suppressed immune system are advised to delay getting the vaccine until they’re healthy enough to do so. (2/1/21)

Este artículo está disponible en español.

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COVID vaccines for people with cancer

Relevance: High

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Strength of Science: High

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Research Timeline: Post Approval

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Study : Immunotherapy drug Keytruda received FDA approval and showed benefit for treatment of colorectal cancer

Most relevant for: People with advanced colorectal cancer and a type of biomarker called MSI-High (MSI-H)

In June 2020, the FDA approved Keytruda (pembrolizumab) as an initial therapy for advanced colorectal cancer. This approval was based on the results from the KEYNOTE-177 study. In this study, Keytruda was more successful than chemotherapy in delaying progression of certain types of colorectal cancers. (11/25/20)

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Immunotherapy drug Keytruda received FDA approval and showed benefit for treatment of colorectal cancer

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