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A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Patients With a Solid Tumor (SEASTAR)

Clinicaltrials.gov identifier:
NCT03992131

Study Contact Information:

Clovis Oncology Clinical Trial Navigation, phone: 1-855-262-3040 or email    

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Overview
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About the Study

This study will look at how safe, effective and tolerable the oral Rucaparib is when used in combination with other anticancer agents in patients with a solid tumor. Note: This study has completed enrollment. 

Type of Study

This is an study, with two treatment arms. 

  • The study has two arms. This means that patients in the study are placed in one of two different groups.
    • One group will received the PARP inhibitor rucaparib () and a second oral medication called lucitanib.
    • The second group will receive the PARP inhibitor rucaparib and an injectable medication called Sacituzumab govitecan (Troveldy).
  • The study is open-label. All participating patients will know which group they have been assigned to. 

This Study is Open To:

Note: This study has completed enrollment. 

This Study is NOT Open To:

For Phase 1, the following exclusions apply:

  • People with a history of a type of bone marrow disorder known as Myelodysplastic Syndromes, or MDS.
  • Symptomatic and/or untreated Central Nervous System (CNS) metastases
  • Exclusion Criteria Phase 2 (both arms):

For Phase 2, the following exclusions apply: 

  • Prior PARP inhibitor treatment allowed for patients with ovarian cancer
  • Known history of MDS
  • Symptomatic and/or untreated Central Nervous System (CNS) metastases

What the Study Involves

Participants will be assigned to one of two groups:

  • Experimental Arm A: Study participants will receive oral (administered twice daily) and oral Lucitanib (administered once daily).
  • Experimental Arm B: Study participants will receive oral Rucaparib (administered twice daily) and IV Sacituzumab Govitecan (administered on days 1 and 8 every 21 days).

Participants in both groups will be followed for up to two years. 

Study Sites

  • Massachusetts
    • Boston: Dana Farber Cancer Institute
    • Contact:  Clovis Oncology Clinical Trial Navigation by phone: 1-855-262-3040 or email    
    • Site PI: Geoffrey Shapiro, MD, PhD      
  • Tennessee
    • Nashville: Sarah Cannon Research Institute
    • Contact:  Clovis Oncology Clinical Trial Navigation by phone: 1-855-262-3040 or email    
    • Site PI: Erika Hamilton, MD   
  • Texas
    • Houston: MD Anderson Cancer Center
    • Contact:  Clovis Oncology Clinical Trial Navigation by phone: 1-855-262-3040 or email    
    • Site PI: Timothy Yap, MBBS, PhD

Study Contact Information:

Clovis Oncology Clinical Trial Navigation, phone: 1-855-262-3040 or email    

Clinicaltrials.gov identifier:
NCT03992131

Study Contact Information:

Clovis Oncology Clinical Trial Navigation, phone: 1-855-262-3040 or email    

PRINTER FRIENDLY PAGE