The WISDOM Study: Women Informed to Screen Depending on Measures of Risk identifier:
NCT02620852 (

Study to Determine if Breast Cancer Screening can be Made Better by Personalizing Each Woman’s Mammogram Schedule

Study Contact Information:

The study is being conducted by researchers at the University of California and at Sanford Health in the Midwest. Contact Information: by phone at 855-729-2844 or by email.


About the Study

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a mammogram. For more information, visit the WISDOM Study website

Type of Study

The Wisdom Study is testing a personalized approach to breast screening versus standard annual screening. Women can now choose which study group they would like to participate in. The WISDOM Study has been going on since 2016 and started as a randomized trial, but has now shifted it’s design so participants can choose their study group.

What the Study Entails

Participants in both groups will then be asked to complete annual follow-up surveys in the years to come about changes in their breast health.

Details on the Enrollment Process

Participation is done completely online by signing up at There is no need to come to a participating center as the study can be completed at home. By joining the study, every woman will gain a better understanding of her personalized breast cancer risk, but also help us chart the way forward for breast cancer screening and prevention. 

Stepwise process:

  1. Visit to learn more about the study
  2. To participate: click Join Now
  3. You will be prompted to complete an Eligibility Survey 
    • If you are confirmed eligible, you will be prompted to create a Portal Password. This along with the email address you providing when completing the Eligibility Survey will serve as your login credentials for your personal Wisdom portal. This web portal is where you will login to view your unique study related information.
  4. Select a Study Group
  5. Review the Consent and HIPAA forms
  6. If you decide that you would like to participate, complete the Consent and HIPAA forms by signing the forms via DocuSign.
  7. Complete the following surveys:
    • Personal Profile Page
    • Breast Health Questionnaire
    • Well-being Survey
  8. If you chose to be in the personalized arm, a genetics (saliva) test will be mailed to you at your home address with instructions on how to complete.

*Some insurance companies have partnered with the Wisdom Study and are covering the genetics test as part of their covered services. Please note that no individual woman will be billed for the genetics test. It will be covered by participating insurers or by the study.

Study Lead Investigator

Laura Esserman, MD MBA: University of California San Francisco

This Study is Open To:


This Study is Not Open To:



FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.