Using a Blood Test to Detect Early Cancer Recurrence After Treatment (ORACLE)
Study Contact Information:
Guardant Health Clinical Trial Operations
📞 855‑698‑8887
📧 [email protected]
About the Study
This study is testing whether a type of blood test called a can find very small amounts of cancer left in the body after treatment—before cancer shows up on scans or causes symptoms.The blood test looks for circulating tumor (), tiny pieces of cancer that may be present in the bloodstream. Researchers want to learn how well this test can:
- Detect cancer recurrence early
- Predict outcomes after treatment
- Support future use of blood‑based monitoring instead of—or in addition to—imaging tests.
This Study is Open To:
This study is open to people 18 years or older with any of the following:
- Have been treated for early‑stage or high‑risk cancer with curative intent (such as surgery, radiation, and/or chemotherapy)
- Are planning to receive routine follow‑up care to monitor for recurrence
- Are willing to provide blood samples during follow‑up visits
This study includes people treated for several cancers, including:
- Bladder cancer that has invaded the muscle, or ureter or kidney pelvis cancer 2-3
- Breast cancer
- Must be considered high-risk for recurrence
- , triple-negative and may all be eligible
- Endometrial cancer 2-3
- Esophageal or gastro-esophageal junction cancers 2-3
- Gastric cancer 2-3
- Head and neck squamous cells cancers 1-4B
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- Lung cancer
- Melanoma 2B-3 or 4 if treated with curative intent
- Ovarian or cancer
- 1C, 2 or 3
- 1A or 1B for high-grade serous or clear cell ovarian cancer
- Pancreatic cancer that is has been surgically removed or is eligible for surgical removal
- Rectal cancer after receiving pre-surgical treatment
This Study is NOT Open To:
People with any of the following are not eligible:
- Neuroendocrine cancer.
- History of another primary cancer diagnosed within 3 years of enrollment.
What the Study Involves
This study is enrolling people with different types of cancer. Check eligibility for cancer types that are eligible.
This is an observational study, which means:
- Participants do not receive a study drug.
- Participants will receive standard of care treatment and follow-up.
If you join:
- Blood samples are collected at enrollment and during routine follow‑up visits.
- Blood draws may continue for up to 5 years.
- Researchers compare blood test results with clinical outcomes, such as whether and when cancer returns.
- Participants do not receive their blood test results.
Study Contact Information:
Guardant Health Clinical Trial Operations
📞 855‑698‑8887
📧 [email protected]
Locations:
Alabama
City: Birmingham RECRUITING
Facility: University of Alabama at Birmingham
Contact Info:
Arizona
City: Chandler RECRUITING
Facility: Ironwood Cancer & Research Centers
Contact Info:
California
City: La Jolla RECRUITING
Facility: University of California, San Diego
Contact Info:
City: Newport Beach RECRUITING
Facility: Hoag Memorial Hospital Presbyterian
Contact Info:
City: Redwood City RECRUITING
Facility: Redwood City
Contact Info:
Colorado
City: Aurora RECRUITING
Facility: University of Colorado
Contact Info:
Florida
City: Hollywood RECRUITING
Facility: Memorial Healthcare System
Contact Info:
City: Lakeland RECRUITING
Facility: The Oncology Institute of Hope & Innovation
Contact Info:
Louisiana
City: New Orleans RECRUITING
Facility: Tulane Cancer Center
Contact Info:
City: Shreveport RECRUITING
Facility: Christus Highland/ Boniol
Contact Info:
Maine
City: Lewiston RECRUITING
Facility: Central Maine Medical Center
Contact Info:
Michigan
City: Grand Rapids RECRUITING
Facility: Cancer & Hematology Centers of Western Michigan
Contact Info:
Minnesota
City: Rochester RECRUITING
Facility: Mayo Clinic (Rochester)
Contact Info:
North Carolina
City: Chapel Hill RECRUITING
Facility: UNC- Chapel Hill
Contact Info:
New Jersey
City: East Brunswick RECRUITING
Facility: Astera Cancer Care
Contact Info:
Ohio
City: Cleveland RECRUITING
Facility: Cleveland Clinic
Contact Info:
City: Toledo RECRUITING
Facility: Toledo Clinic Cancer Center
Contact Info:
Pennsylvania
City: Philadelphia RECRUITING
Facility: University of Pennsylvania
Contact Info:
City: York RECRUITING
Facility: Cancer Care Associates of York
Contact Info:
South Carolina
City: Myrtle Beach RECRUITING
Facility: Carolina Urologic Research Center
Contact Info:
City: Rock Hill RECRUITING
Facility: Carolina Blood and Cancer Care Associates
Contact Info:
Texas
City: Dallas RECRUITING
Facility: UT Southwestern Medical Center
Contact Info:
City: Edinburg RECRUITING
Facility: DHR Health Advance Care Center
Contact Info:
City: Forth Worth RECRUITING
Facility: The Center for Cancer and Blood Disorders
Contact Info:
City: San Antonio RECRUITING
Facility: The University of Texas Health Science Center at San Antonio
Contact Info:
Utah
City: Salt Lake City RECRUITING
Facility: Utah Cancer Specialists
Contact Info:
Wisconsin
City: Appleton RECRUITING
Facility: ThedaCare Regional Cancer Center
Contact Info:
Other Countries
Country: France
City: Besançon RECRUITING
Facility: CHU Besançon
Contact Info:
Country: France
City: Levallois-Perret RECRUITING
Facility: Hôpital Franco-Britannique
Contact Info:
Country: France
City: Marseille RECRUITING
Facility: Institut Paoli-Calmettes
Contact Info:
Country: France
City: Neuilly RECRUITING
Facility: Ambroise Paré-Hartmann
Contact Info:
Country: France
City: Paris RECRUITING
Facility: APHP Tenon Hospital - Sorbonne
Contact Info:
Country: Germany
City: Hamburg RECRUITING
Facility: Asklepios Klinik Altona
Contact Info:
Country: Germany
City: Heilbronn RECRUITING
Facility: SLK-Kliniken Heilbronn GmbH
Contact Info:
Country: Germany
City: Munich RECRUITING
Facility: Ludwig Maximilian University Munich
Contact Info:
Country: Italy
City: Meldola RECRUITING
Facility: Instituto Romagnolo per lo Studio dei Tumori "Dino Amadori" IRCCS IRST, SrL
Contact Info:
Country: Italy
City: Reggio Emilia RECRUITING
Facility: Azienda USL-IRCCS di Reggio Emilia
Contact Info:
Country: Italy
City: Roma RECRUITING
Facility: Policlinico Universitario Agostino Gemelli
Contact Info:
Country: Spain
City: A Coruña RECRUITING
Facility: Hospital Teresa Herrera (C.H.U.A.C)
Contact Info:
Country: Spain
City: Barcelona RECRUITING
Facility: Vall Hebron Institute of Oncology
Contact Info:
Country: Spain
City: Barcelona RECRUITING
Facility: Hospital Clinic of Barcelona
Contact Info:
Country: Spain
City: Barcelona RECRUITING
Facility: ICO Institut Catala d'Oncologia
Contact Info:
Country: Spain
City: Girona RECRUITING
Facility: Instituto Catalan de Oncologia de Girona
Contact Info:
Country: Spain
City: Las Palmas de Gran Canaria RECRUITING
Facility: Hospital Universitario Insular de Gran Canaria
Contact Info:
Country: Spain
City: Madrid RECRUITING
Facility: Hospital San Carlos
Contact Info:
Country: Spain
City: Madrid RECRUITING
Facility: Hospital Universitario La Paz
Contact Info:
Country: Spain
City: Madrid RECRUITING
Facility: CIOSS HM Sanchinarro
Contact Info:
Country: Spain
City: Málaga RECRUITING
Facility: Hospital Universitario Virgen de la Victoria
Contact Info:
Country: Spain
City: Sabadell RECRUITING
Facility: CCS Hospital Universitari Parc Taulí
Contact Info:
Country: Spain
City: Santiago de Compostela RECRUITING
Facility: Hospital Clinico de Santiago de Compostela
Contact Info:
Country: Spain
City: Valencia RECRUITING
Facility: Hospital Clínico de Valencia
Contact Info:
Study Contact Information:
Guardant Health Clinical Trial Operations
📞 855‑698‑8887
📧 [email protected]