The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

https://www.facingourrisk.org/research-clinical-trials/study/360/the-prostate-cancer-genetic-risk-and-equitable-screening-study-progress

Clinicaltrials.gov identifier:
NCT05926102 (https://clinicaltrials.gov/show/NCT05926102)

Prevention
Prostate cancer screening study for male US veterans age 55–69

Study Contact Information:

Name: Charles A Brunette, PhD
Phone Number: (857) 364-6324
Email: [email protected]

About the Study

This study is testing using a person’s genetics to guide screening that can make prostate cancer testing more accurate and reduce harms. Participants will have genetic testing to estimate their risk for prostate cancer.

The study will use this genetic information to give Veterans and their primary care providers personalized screening recommendations. The goal is to learn if using genetic testing can find men at higher risk who may benefit from prostate cancer screening, while helping men at lower risk avoid unnecessary procedures.

What the Study Involves

Participants will be randomly assigned to one of two groups.

Precision Screening Group: Participants will receive a genetic risk report for prostate cancer, personalized screening recommendations, and—if they are found to be at high genetic risk—genetic counseling. Their primary care provider will also receive the report and educational materials. High-risk men will be advised to get PSA screening, while low-risk men will be advised not to screen.
Usual Care Group: Participants will receive a short brochure about shared decision-making in prostate cancer screening.

All participants will be followed for a period of 7 years. During that time, researchers will track prostate cancer diagnoses, PSA tests, MRIs, genetic findings, screening preferences, and health-related quality of life.

This Study is Open To:

Men 55-69 years old who:

Receive regular VA care
Are Veteran status

This Study is Not Open To:

Men with the following are not eligible to participate:

Have a diagnosis of prostate cancer
Have had a prior prostate biopsy, prostatectomy, or prostate MRI
Are confirmed to already have an inherited mutation (also known as a pathogenic variant) associated with cancer

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.