The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

https://www.facingourrisk.org/research-clinical-trials/study/360/the-prostate-cancer-genetic-risk-and-equitable-screening-study-progress

Clinicaltrials.gov identifier:
NCT05926102 (https://clinicaltrials.gov/show/NCT05926102)

Prevention
This study is for male U.S. Veterans (age 55–69) who want to learn about their risk for prostate cancer

Study Contact Information:

Name: Charles A Brunette, PhD

Phone Number: (857) 364-6324

Email: [email protected]

About the Study

This study is testing whether precision screening—using a person’s genetics to guide screening—can make prostate cancer testing more accurate and reduce harms. Participants will have genetic testing that looks for rare genetic variants and a polygenic risk score (PRS), which estimates a person’s inherited risk of prostate cancer.

The study will use this genetic information to give Veterans and their primary care providers personalized screening recommendations. The goal is to find men at higher risk who may benefit from early testing, while helping men at lower risk avoid unnecessary procedures.

What the Study Involves

Participants will be randomly assigned to one of two groups.

Precision Screening Group: Participants will receive a genetic risk report for prostate cancer, personalized screening recommendations, and—if they are found to be at high genetic risk—genetic counseling. Their primary care provider will also receive the report and educational materials. High-risk men will be advised to get PSA screening, while low-risk men will be advised not to screen.
Usual Care Group: Participants will receive a short brochure about shared decision-making in prostate cancer screening.

All participants will be followed for a period of 7 years. During that time, researchers will track prostate cancer diagnoses, PSA tests, MRIs, genetic findings, screening preferences, and health-related quality of life.

This Study is Open To:

Men 55-69 years old who:

Receive regular VA care
Are Veteran status

This Study is Not Open To:

Men with the following are not eligible to participate:

Have a personal history of prostate cancer
Have had a prior prostate biopsy, prostatectomy, or prostate MRI
Are confirmed to already have a rare genetic variant associated with cancer

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.