Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women (TUBA/WISP II) identifier:
NCT05287451 (

Prevention study for women at high risk for ovarian cancer

Study Contact Information:

Contact: Karen Lu, MD
by phone: 713-745-8902
or by email: [email protected]  

About the Study

This study is looking at whether removal of the fallopian tubes (salpingectomy) followed by removal of the ovaries (oophorectomy) at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and fallopian tubes at the same time (salpingo-oophorectomy) among women with an inherited BRCA1, BRCA2, BRIP1, RAD51C or RAD51D mutation. Removing the fallopian tubes only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.

What the Study Involves

Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference. 

Study Sites

Harvard Cancer Center
Contact: Colleen Feltmate, MD by phone 617-732-8843 or email [email protected]

St. Louis
Washington Univeristy School of Medicine
Contact: Andrea Hagemann, MD by phone 314-362-3181 or by email [email protected]

M D Anderson Cancer Center
Contact: Karen Lu, MD by phone: 713-745-8902 or by email [email protected]  

University of Washington Cancer Center
Contact: Barb Norquist, MD by email: [email protected] or contact the study coordinator at: 206-616-3913

This Study is Open To:

Women are eligible if they:

This Study is Not Open To:

Women cannot participate if they:


FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.