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Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)

Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)

Clinicaltrials.gov identifier:
NCT02997228

Treatment:
Colorectal

Study Contact Information:

For additional information, please contact:

Principal Investigator:  Caio Max S Rocha Lima at NRG Oncology by phone: 336-713-6771 or by email     

Chemotherapy, Bevacizumab, and/or Atezolizumab for Patients With Deficient DNA Mismatch Repair (dMMR or MSI-H) Metastatic Colorectal Cancer, the COMMIT Study

About the Study

This study is for people with metastatic colorectal cancer. The study will compare how well treatment with a combination of chemotherapy agents and an immunotherapy agent works compared with treatment using an immunotherapy agent alone. This study is focused on patients who are determined to be mismatch-repair deficient (dMMR) or have an MSI-H diagnosis, which are commonly seen in people with Lynch syndrome.


Type of Study

The study is an open-label, Phase III, randomized study.  

There are two remaining treatment groups in this study. One group will receive combination chemotherapy along with the immunotherapy drug atezolizumab.  The other group will receive immunotherapy drug atezolizumab alone. (A third study group who were to receive combination chemotherapy alone is no longer accepting new patients.) 

The study is randomized; participants will be placed into one of the two study groups by chance.

The study is open-label. All participating patients will know which of the two groups they have been assigned to and which treatments they are being given.


What the Study Entails

Patients will be assigned randomly to either Group 2 or Group 3.

  • Group 1: Chemotherapy Only - This study group is closed
  • Group 2: Immunotherapy Only
    • Patients receive the immunotherapy atezolizumab IV over 30-60 minutes on day 1.
    • Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity.
  • Group 3: Chemotherapy and Immunotherapy
    • Patients receive atezolizumab IV over 30-60 minutes on day 1. Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity.
    • Patients also receive combination chemotherapy intravenously (bevacizumab oxaliplatin, leucovorin calcium and fluorouracil) starting on day 1.  Treatment with oxaliplatin repeats every 2 weeks for up to 10 cycles in the absence of disease progression or unacceptable toxicity.  Cycles of bevacizumab, leucovorin calcium, and fluorouracil repeat every 2 weeks in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 8 weeks for 18 months, and then every 12 weeks for up to 5 years.


Study Sites

Arkansas California Colorado
Connecticut Delaware District of Columbia
Florida Georgia Idaho
Illinios Indiana Iowa
Kansas Kentucky Louisiana
Maine Maryland Michigan
Minnesota Mississippi Missouri
Montana Nebraska Nevada
New Hampshire New Jersey New Mexico
New York North Carolina North Dakota
Ohio Oklahoma Oregon
Pennsylvania South Carolina South Dakota
Tennessee Texas Utah
Vermont Virginia Washington
West Virginia Wisconsin Wyoming


Arkansas

  • Jonesboro: Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro  
    Contact: Emily Carvell by phone: 870-936-7066 or by email.     

California

  • Anaheim: Kaiser Permanente-Anaheim
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher   
  • Baldwin Park: Kaiser Permanente-Baldwin Park
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher    
  • Bellflower: Kaiser Permanente-Bellflower
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email. 
  • Berkeley: Alta Bates Summit Medical Center-Herrick Campus
    Contact: Site Contact by phone 415-209-2686 or by email.     
    Principal Investigator: Kristie A. Bobolis 
  • Fontana: Kaiser Permanente-Fontana 
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher 
  • Harbor City: Kaiser Permanente - Harbor City
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher 
  • Irvine: Kaiser Permanente-Irvine     
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher
  • Los Angeles: Kaiser Permanente Los Angeles Medical Center      
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher 
  • Marysville: Fremont - Rideout Cancer Center 
    Contact: Site Contact by phone: 530-749-4400     
    Principal Investigator: Edward J. Kim       
  • Modesto: Memorial Medical Center
    Contact: Site Contact by phone 415-209-2686 or by email.     
    Principal Investigator: Kristie A. Bobolis 
  • Ontario: Kaiser Permanente-Ontario
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher  
  • Orange: Saint Joseph Hospital - Orange          
    Contact: Site Contact by phone: 714-734-6220     
    Principal Investigator: Timothy E. Byun 
  • Irvine: UC Irvine Health/Chao Family Comprehensive Cancer Center         
    Study Contact: by phone at  877-827-8839 or by email.      
    Principal Investigator: Fa-Chyi Lee
  • Panorama City: Kaiser Permanente - Panorama City 
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher
  • Riverside: Kaiser Permanente-Riverside
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher  
  • Sacramento: University of California Davis Comprehensive Cancer Center          
    Site Contact: by phone: 916-734-3089     
    Principal Investigator: Edward J. Kim
  • San Diego: Kaiser Permanente-San Diego Mission         
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher  
  • San Diego: Kaiser Permanente-San Diego Zion        
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher  
  • San Marcos: Kaiser Permanente-San Marcos   
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher    
  • Whittier:Presbyterian Intercommunity Hospital        
    Contact: Site Public Contact    562-698-0811     
    Principal Investigator: Lisa S. Wang
  • Woodland Hills: Kaiser Permanente-Woodland Hills       
    Contact: Kaiser Permanente Research by phone 800-398-3996 or by email.      
    Principal Investigator: Gary L. Buchschacher  

Colorado

  • Aurora: Rocky Mountain Cancer Centers-Aurora      
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella  
  • Aurora: University of Colorado Hospital        
    Contact: Site Public Contact    720-848-0650     
    Principal Investigator: Alexis D. Leal
  • Boulder: Rocky Mountain Cancer Centers-Boulder 
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella  
  • Colorado Springs: Penrose-Saint Francis Healthcare     
    Contact: Site Public Contact  by phone 308-398-6518  or by email.      
    Principal Investigator: Richard L. Deming
  • Colorado Springs: UCHealth Memorial Hospital Central
    Contact: Site Public Contact by phone: 719-365-2406     
    Principal Investigator: Alexis D. Leal
  • Colorado Springs: Memorial Hospital North
    Contact: Site Public Contact by phone: 719-365-2406     
    Principal Investigator: Alexis D. Leal
  • Denver: National Jewish Health-Main Campus          
    Contact: Site Public Contact  by phone  877-225-5654 or by email.   
    Principal Investigator: Nicholas DiBella    
  • Denver: Boulder: Rocky Mountain Cancer Centers-Midtown 
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella  
  • Denver: Boulder: Rocky Mountain Cancer Centers-Rose 
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella
  • Englewood: Mountain Blue Cancer Care Center - Swedish 
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella  
  • Swedish Medical Center
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella
  • Fort Collins:Poudre Valley Hospital          
    Contact: Site Public Contact    970-297-6150     
    Principal Investigator: Alexis D. Leal 
  • Fort Collins: Cancer Care and Hematology-Fort Collins    
    Contact: Site Public Contact by phone 412-339-5294 or by email.     
    Principal Investigator: Alexis D. Leal 
  • Golden: National Jewish Health-Western Hematology Oncology      
    Contact: Site Public Contact  by phone  877-225-5654 or by email.   
    Principal Investigator: Nicholas DiBella     
  • Greeley: North Colorado Medical Center
    Contact: Site Contact at: 303-777-2663  or by email.       
    Principal Investigator: Nicholas DiBella  
  • Greeley: UCHealth Greeley Hospital   
    Contact: Site Public Contact by phone 412-339-5294 or by email.     
    Principal Investigator: Alexis D. Leal 
  • Littleton: Rocky Mountain Cancer Centers-Littleton   
    Contact: Site Public Contact by phone 303-777-2663 or by email.   
    Principal Investigator: Nicholas DiBella       
  • Lone Tree: Rocky Mountain Cancer Centers-Sky Ridge
    Contact: Site Public Contact by phone 303-777-2663 or by email.   
    Principal Investigator: Nicholas DiBella
  • Loveland: Medical Center of the Rockies         
    Contact: Site Public Contact    970-203-7083     
    Principal Investigator: Alexis D. Leal   
  • Loveland:  McKee Medical Center          
    Contact: Site Public Contact by phone 303-777-2663 or by email.   
    Principal Investigator: Nicholas DiBella
  • Thornton: National Jewish Health-Northern Hematology Oncology    
    Contact: Site Public Contact by phone 303-777-2663 or by email.   
    Principal Investigator: Nicholas DiBella 

Connecticut

  • Danbury: Danbury Hospital      
    Contact: Site Public Contact    203-739-8074     
    Principal Investigator: Wenli Gao        
  • Hartford: Hartford Hospital      
    Contact: Site Public Contact    860-545-5363     
  • Principal Investigator: Gerard Fumo      

Delaware

  • Newark: Helen F Graham Cancer Center         
    Contact: Site Public Contact by phone 302-623-4450 or by email.  
    Principal Investigator: Gregory A. Masters 
  • Newark: Medical Oncology Hematology Consultants PA       
    Contact: Site Public Contact by phone 302-623-4450 or by email.  
    Principal Investigator: Gregory A. Masters        
  • Rehoboth Beach: Beebe Health Campus
    Contact: Site Public Contact    302-645-3100 or by email.  
    Principal Investigator: Gregory A. Masters              

District of Columbia

  • Kaiser Permanente-Capitol Hill Medical Center       
    Contact: Site Public Contact    301-548-5743     
    Principal Investigator: Leon C. Hwang

Florida

  • Fort Myers: Regional Cancer Center-Lee Memorial Health System         
    Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org  
    Principal Investigator: Paul M. Bloomston  
  • Gainesville: University of Florida Health Science Center - Gainesville    
    Contact: Site Public Contact    352-273-8010 or by email.    
    Principal Investigator: Thomas J. George        
  • Orlando: AdventHealth Orlando          
    Contact: Site Public Contact    407-303-2090 or by email.     
    Principal Investigator: Mohamedtaki A. Tejani    

Georgia

  • Albany: Phoebe Putney Memorial Hospital   
    Contact: Site Public Contact    229-312-0405 or by email.     
    Principal Investigator: Sharad A. Ghamande      
  • Athens: University Cancer and Blood Center LLC       
    Contact: Site Public Contact  by phone 706-353-5006 or by email.     
    Principal Investigator: Sharad A. Ghamande
  • Augusta: Augusta Oncology Associates PC-D'Antignac
    Contact: Site Public Contact    706-821-2944     
    Principal Investigator: Sharad A. Ghamande      
  • Augusta:  Augusta Oncology Associates PC-Wheeler   
    Contact: Site Public Contact    706-736-1830     
    Principal Investigator: Sharad A. Ghamande
  • Augusta: Augusta University Medical Center  
    Contact: Site Public Contact by phone 706-721-2388 or by email.     
    Principal Investigator: Sharad A. Ghamande    
  • Newnan: CTCA at Southeastern Regional Medical Center       
    Contact: Site Public Contact    770-400-6629     
    Principal Investigator: Eyal Meiri        

Idaho

  • Boise: Saint Alphonsus Cancer Care Center-Boise  
    Contact: Site Public Contact    734-712-3671 or by email.       
    Principal Investigator: John M. Schallenkamp   
  • Boise: Saint Luke's Cancer Institute - Boise 
    Contact: Site Public Contact    208-381-2774 or by email     .
    Principal Investigator: Krishna C. Alluri   
  • Caldwell: Saint Alphonsus Cancer Care Center-Caldwell; Contact: 734-712-3671 or email     
  • Coeur d'Alene: Kootenai Medical Center; Contact: 406-969-6060 or email      
  • Fruitland: Saint Luke's Cancer Institute - Fruitland; Contact: 208-381-2774 or email      
  • Meridian: Saint Luke's Cancer Institute - Meridian; Contact: 208-381-2774 or email      
  • Nampa: Saint Alphonsus Medical Center-Nampa; Contact: 734-712-3671 or email     
  • Nampa: Saint Luke's Cancer Institute - Nampa; Contact: 208-381-2774 or email     
  • Post Falls: Kootenai Cancer Center; Contact: 406-969-6060 or email     
  • Sandpoint: Kootenai Cancer Center; Contact: 406-969-6060 or email      
  • Twin Falls:Saint Luke's Cancer Institute - Twin Falls; Contact: 208-381-2774 or email      

Illinois

  • Bloomington: Illinois CancerCare-Bloomington; Contact:  309-243-3605 or email        
  • Canton: Illinois CancerCare-Canton; Contact:  309-243-3605 or email       
  • Carterville: SIH Cancer Institute; Contact: 618-985-3333 or email     
  • Carthage: Illinois CancerCare-Carthage; Contact:  309-243-3605 or email          
  • Chicago: Rush University Medical Center; Contact : 312-942-5498 or email  
  • Chicago: University of Illinois, Chicago; Contact: 312-355-3046       
  • Danville: Carle on Vermilion: Contact: 800-446-5532 or by email  
  • Decatur: Cancer Care Specialists of Illinois - Decatur; Contact: 217-876-4740 or email       
  • Dixon: Illinois CancerCare-Dixon; Contact 815-285-7800
  • Effingham: Carle Physician Group-Effingham 800-446-5532  or by email 
  • Effingham: Crossroads Cancer Center; Contact: 217-876-4740  or by email     
  • Eureka: Illinois CancerCare-Eureka; Contact 309-243-3605  or email      
  • Evanston: NorthShore University HealthSystem-Evanston Hospital; Contact: 847-570-2109         
  • Galesburg: Illinois CancerCare-Galesburg; Contact: 309-243-3605  or email 
  • Glenview: NorthShore University HealthSystem-Glenbrook Hospital; Contact: 847-570-2109
  • Harvey:Ingalls Memorial Hospital; Contact: 708-915-4673    clinicaltrials@ingalls.org  
  • Highland Park: NorthShore University HealthSystem-Highland Park Hospital: Contact: 847-570-2109  
  • Kewanee: Illinois CancerCare-Kewanee Clinic; Contact: 309-243-3605 or email 
  • Macomb: Illinois CancerCare-Macomb; Contact: 309-243-3605 or email 
  • Mattoon: Carle Physician Group-Mattoon/Charleston: 800-446-5532  or by email 
  • Maywood: Loyola University Medical Center; Contact: 708-226-4357     
  • Mount Vernon: Good Samaritan Regional Health Center; Contact: 618-242-4600
  • O'Fallon: Cancer Care Center of O'Fallon; Contact    217-876-4762 or by email     
  • Ottawa: Illinois CancerCare-Ottawa Clinic; Contact: 309-243-3605 or by email    
  • Pekin: Illinois CancerCare-Pekin; Contact: 309-243-3605 or by email    
  • Peoria: Illinois CancerCare-Peoria; Contact: 309-243-3605 or by email  
  • Peru: Illinois CancerCare-Peru; Contact: 309-243-3605 or by email     
  • Princeton: Illinois CancerCare-Princeton; Contact: 309-243-3605 or by email 
  • Silvis: Genesis Cancer Center - Silvis; Contact: 563-421-1908  or by email    
  • Springfield: Southern Illinois University School of Medicine; Contact: 217-545-7929     
  • Springfield: Springfield Clinic; Contact: 800-444-7541
  • Urbana: Carle Cancer Center; Contact: 800-446-5532  or by email   

Indiana

  • Indianapolis: Franciscan Health Indianapolis; Contact: 317-528-7060     
  • Mooresville: Franciscan Health Mooresville; Contact: 317-834-3603     

Iowa

  • Bettendorf: University of Iowa Healthcare Cancer Services Quad Cities; Contact: 563-355-7733 or by email   
  • Cedar Rapids: Mercy Hospital; Contact: 319-365-4673
  • Cedar Rapids: Oncology Associates at Mercy Medical Center; Contact    319-363-2690     
  • Clive: Medical Oncology and Hematology Associates-West Des Moines; Contact: 308-398-6518 or by email   
  • Clive: Mercy Cancer Center-West Lakes; Contact: 308-398-6518 or by email
  • Des Moines: Medical Oncology and Hematology Associates-Des Moines; Contact: 515-282-2921 
  • Des Moines: Broadlawns Medical Center; Contact: 515-282-2200
  • Des Moines: Medical Oncology and Hematology Associates-Laurel; Contact: 308-398-6518 or by email    
  • Des Moines: Mercy Medical Center - Des Moines; Contact: 308-398-6518 or by email 
  • Fort Dodge: McFarland Clinic PC-Trinity Cancer Center; Contact : 515-574-8302     
  • Iowa City: University of Iowa/Holden Comprehensive Cancer Center; Contact: 800-237-1225       
  • West Des Moines: Mercy Medical Center-West Lakes; Contact: 308-398-6518 or by email          

Kansas

  • Hays: HaysMed University of Kansas Health System;  785-623-5774   
  • Lawrence: Lawrence Memorial Hospital; Contact: 785-505-2800 or by email    
  • Olathe: Olathe Health Cancer Center; Contact: 913-355-8000 or by email     
  • Salina: Salina Regional Health Center;  Contact: 785-452-7038 or by email    
  • Topeka: University of Kansas Health System Saint Francis Campus; Contact: 785-295-8000   
  • Westwood: University of Kansas Hospital-Westwood Cancer Center; Contact: 913-588-3671 or by email   
  • Wichita: Cancer Center of Kansas-Wichita Medical Arts Tower; Contact: 316-268-5374 or by email            

Kentucky

  • Lexington: Baptist Health Lexington; Contact: 859-260-6425
  • Lexington: Saint Joseph Hospital East; Contact:  308-398-6518 or by email     
  • Lexington: University of Kentucky/Markey Cancer Center; Contact: 859-257-3379     

Louisiana

  • Kenner: Ochsner Medical Center Kenner; Contact: 504-464-8314 or by email         
  • New Orleans: Ochsner Medical Center Jefferson; Contact: 504-703-8712 or by email       

Maine

  • Augusta: Harold Alfond Center for Cancer Care; Contact: 207-626-4855
  • Bangor: Eastern Maine Medical Center; Contact    207-973-4274      
  • Biddeford:  MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford; Contact by email         
  • Brewer: Lafayette Family Cancer Center-EMMC; Contact:    800-987-3005      
  • Sanford: MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford; Contact by email   
  • South Portland: Maine Medical Partners - South Portland; Contact: 207-396-8670 or by email      

Maryland

  • Baltimore: Kaiser Permanente-Woodlawn Medical Center; Contact: 301-816-7218
  • Easton: University of Maryland Shore Medical Center at Easton; Contact:  410-822-1000 or by email       
  • Gaithersburg: Kaiser Permanente-Gaithersburg Medical Center; Contact:  301-816-7218  
  • Largo: Kaiser Permanente - Largo Medical Center; Contact:  301-816-7446     

Massachusetts

  • Boston: Dana-Farber Cancer Institute; Contact: 877-442-3324          

Michigan

  • Ann Arbor: Saint Joseph Mercy Hospital; Contact: 734-712-3671 or by email                 
  • Bay City: McLaren Cancer Institute-Bay City; Contact: 313-576-9790 or by email    
  • Bloomfield: McLaren Cancer Institute-Bloomfield; Contact: 313-576-9790 or by email    
  • Brighton: IHA Hematology Oncology Consultants-Brighton; Contact: 734-712-3671 or by email   
  • Brighton: Saint Joseph Mercy Brighton; Contact: 734-712-3671 or by email 
  • Brownstown: Henry Ford Cancer Institute-Downriver; Contact: 313-916-3721 or by email   
  • Canton: IHA Hematology Oncology Consultants-Canton; Contact: 734-712-3671  or by email  
  • Canton: Saint Joseph Mercy Canton; Contact: 734-712-3671 or by email  
  • Chelsea: IHA Hematology Oncology Consultants-Chelsea; Contact: 734-712-3671  or by email
  • Chelsea: Saint Joseph Mercy Chelsea; Contact: 734-712-3671  or by email
  • Clarkston: Hematology Oncology Consultants-Clarkston; Contact: 734-712-3671  or by email
  • Clarkston: McLaren Cancer Institute-Clarkston; Contact: 313-576-9790  or by email 
  • Clinton Township: Henry Ford Macomb Hospital-Clinton Township; Contact: 313-916-3721 or by email
  • Dearborn: Henry Ford Medical Center-Fairlane; Contact: 313-916-3721 or by email
  • Detroit:Wayne State University/Karmanos Cancer Institute; Contact: 313-576-9790 or by email 
  • Detroit: Henry Ford Hospital; Contact: 313-916-3721 or by email  
  • Farmington Hills: Weisberg Cancer Treatment Center; Contact: 313-576-9790 or by email 
  • Flint: McLaren Cancer Institute-Flint; ; Contact: 313-576-9790 or by email           
  • Flint: Singh and Arora Hematology Oncology PC; Contact: 313-576-9790 or by email   
  • Grand Rapids: Spectrum Health at Butterworth Campus; Contact: 616-391-1230 or by email  
  • Jackson: Allegiance Health; Contact: 313-916-3721 or by email
  • Kalamazoo: West Michigan Cancer Center; Contact:  616-391-1230 or by email 
  • Lansing: McLaren-Greater Lansing; Contact: 313-576-9790 or by email   
  • Lansing: Sparrow Hospital; Contact: 734-712-3671  or by email
  • Lapeer: McLaren Cancer Institute-Lapeer Region; Contact: 313-576-9790 or by email 
  • Livonia: Hope Cancer Clinic; Contact: 734-712-3671  or by email    
  • Livonia: Saint Mary Mercy Hospital; Contact: 734-712-3671  or by email   
  • Mount Clemens: McLaren Cancer Institute-Macomb; Contact: 313-576-9790 or by email       
  • Mount Pleasant: McLaren Cancer Institute-Central Michigan; Contact: 313-576-9790 or by email    
  • Novi: Henry Ford Medical Center-Columbus; Contact: 313-916-3721 or by email         
  • Petoskey: McLaren Cancer Institute-Northern Michigan; Contact: 313-576-9790 or by email         
  • Pontiac: Newland Medical Associates-Pontiac; Contact: 734-712-3671  or by email 
  • Pontiac: Saint Joseph Mercy Oakland; Contact: 734-712-3671  or by email  
  • Port Huron: McLaren-Port Huron; Contact: 313-576-9790 or by email   
  • Saginaw: Ascension Saint Mary's Hospital; Contact: 734-712-3671  or by email         
  • Saginaw: Oncology Hematology Associates of Saginaw Valley PC; Contact: 734-712-3671  or by email 
  • Tawas City: Ascension Saint Joseph Hospital; Contact: 734-712-3671  or by email 
  • Traverse City: Munson Medical Center; Contact: 616-391-1230 or by email 
  • West Bloomfield: Henry Ford West Bloomfield Hospital; Contact: 313-916-3721 or by email
  • West Branch: Saint Mary's Oncology/Hematology Associates of West Branch; Contact: 734-712-3671  or by email 
  • Ypsilanti: IHA Hematology Oncology Consultants-Ann Arbor; Contact: 734-712-3671  or by email      

Minnesota

  • Bemidji: Sanford Joe Lueken Cancer Center; Contact: 218-333-5000 or by email       
  • Burnsville: Fairview Ridges Hospital; Contact: 952-993-1517 or by email      
  • Coon Rapids: Mercy Hospital; Contact: 952-993-1517 or by email     
  • Deer River: Essentia Health - Deer River Clinic; Contact: 218-786-3308 or by email      
  • Duluth: Essentia Health Cancer Center; Contact: 218-786-3308 or by email     
  • Hibbing: Essentia Health Hibbing Clinic; Contact: 218-786-3308 or by email      
  • Maplewood: Minnesota Oncology Hematology PA-Maplewood; Contact: 952-993-1517 or by email     
  • Minneapolis: Health Partners; Contact: 952-993-1517 or by email       
  • Saint Paul: Regions Hospital; Contact: 952-993-1517 or by email 
  • Virginia: Essentia Health Virginia Clinic; Contact: 218-786-3308 or by email     

Mississippi

  • Grenada: Baptist Cancer Center-Grenada; Contact: 901-226-1366 or by email      
  • New Albany: Baptist Memorial Hospital and Cancer Center-Union County; Contact: 901-226-1366 or by email
  • Oxford: Baptist Memorial Hospital and Cancer Center-Oxford; Contact: 901-226-1366 or by email        
  • Southhaven: Baptist Memorial Hospital and Cancer Center-Desoto            

Missouri

 

  • Ballwin: Saint Louis Cancer and Breast Institute-Ballwin; Contact: 314-251-7058     
  • Cape Girardeau: Saint Francis Medical Center; Contact: 573-334-2230    sfmc@sfmc.net
  • Joplin: Mercy Hospital Joplin; Contact: 417-556-3074    esmeralda.carrillo@mercy.net        
  • Kansas City: Truman Medical Centers; Contact: 816-404-4375    
  • Saint Louis: Saint Louis Cancer and Breast Institute-South City; Contact: 314-353-1870   
  • Saint Louis: Mercy Hospital Saint Louis; Contact: 314-251-7066     

Montana

Community Hospital of Anaconda    

Anaconda, Montana

Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   

 

Billings Clinic Cancer Center  

Billings, Montana

Contact: Site Public Contact    800-996-2663    research@billingsclinic.org  

     

Bozeman Deaconess Hospital

Bozeman, Montana

Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   

  

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana

Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org  

Principal Investigator: John M. Schallenkamp    

   

Kalispell Regional Medical Center     

Kalispell, Montana

Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org  

Principal Investigator: John M. Schallenkamp        

 

Community Medical Hospital

Missoula, Montana

Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org  

   

Nebraska

Nebraska Methodist Hospital

Omaha, Nebraska

Contact: Site Public Contact    402-354-5144     

Principal Investigator: Timothy Huyck     

  

Nevada

OptumCare Cancer Care at Seven Hills         

Henderson, Nevada

Contact: Site Public Contact    702-384-0013    research@sncrf.org  

Principal Investigator: John A. Ellerton        

 

OptumCare Cancer Care at Oakey    

Las Vegas, Nevada

Contact: Site Public Contact    702-384-0013    research@sncrf.org  

Principal Investigator: John A. Ellerton       

 

OptumCare Cancer Care at MountainView  

Las Vegas, Nevada

Contact: Site Public Contact    702-384-0013    research@sncrf.org  

Principal Investigator: John A. Ellerton     

  

OptumCare Cancer Care at Fort Apache       

Las Vegas, Nevada

Contact: Site Public Contact    702-384-0013    research@sncrf.org  

Principal Investigator: John A. Ellerton        

 

Renown Regional Medical Center     

Reno, Nevada

Contact: Site Public Contact    702-384-0013    research@sncrf.org  

Principal Investigator: John A. Ellerton        

 

New Hampshire

Dartmouth Hitchcock Medical Center          

Lebanon, New Hampshire

Contact: Site Public Contact    800-639-6918    cancer.research.nurse@dartmouth.edu  

Principal Investigator: Kathryn C. Hourdequin        

 

Norris Cotton Cancer Center-Manchester    

Manchester, New Hampshire

Contact: Site Public Contact    603-629-1828     

Principal Investigator: Kathryn C. Hourdequin     

  

Norris Cotton Cancer Center-Nashua

Nashua, New Hampshire

Contact: Site Public Contact    603-577-4282    Laura.A.Menken@hitchcock.org  

Principal Investigator: Kathryn C. Hourdequin   

    

New Jersey

The Cancer Institute of New Jersey Hamilton          

Hamilton, New Jersey

Contact: Site Public Contact    609-631-6946     

Principal Investigator: Howard S. Hochster    

   

Rutgers Cancer Institute of New Jersey        

New Brunswick, New Jersey

Contact: Site Public Contact    732-235-7356     

Principal Investigator: Howard S. Hochster  

     

The Valley Hospital-Luckow Pavilion

Paramus, New Jersey

Contact: Site Public Contact    201-634-5792     

Principal Investigator: Kevin C. Wood        

 

Valley Hospital          

Ridgewood, New Jersey

Contact: Site Public Contact    201-634-5792    cparish@valleyhealth.com  

Principal Investigator: Kevin C. Wood        

 

Robert Wood Johnson University Hospital Somerset          

Somerville, New Jersey

Contact: Site Public Contact    908-685-2481    Siby.Varughese@rwjbh.org  

Principal Investigator: Beiqing Pan     

  

New Mexico

University of New Mexico Cancer Center     

Albuquerque, New Mexico

Contact: Site Public Contact    505-925-0366    LByatt@nmcca.org  

Principal Investigator: Jessica Belmonte    

   

Presbyterian Kaseman Hospital        

Albuquerque, New Mexico

Contact: Site Public Contact    505-559-6113    WBurman@phs.org  

Principal Investigator: Jessica Belmonte      

 

Memorial Medical Center - Las Cruces         

Las Cruces, New Mexico

Contact: Site Public Contact    575-556-6545    Kim.Hoffman@lpnt.net  

Principal Investigator: Jessica Belmonte      

 

Presbyterian Rust Medical Center/Jorgensen Cancer Center          

Rio Rancho, New Mexico

Contact: Site Public Contact    505-559-6113    WBurman@phs.org  

Principal Investigator: Jessica Belmonte       

 

New York

Arnot Ogden Medical Center/Falck Cancer Center  

Elmira, New York

Contact: Site Public Contact    607-271-7000     

Principal Investigator: Serge Dauphin        

 

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York

Contact: Site Public Contact    212-263-4434    prmc.coordinator@nyumc.org  

Principal Investigator: Daniel J. Becker   

    

North Carolina

UNC Lineberger Comprehensive Cancer Center       

Chapel Hill, North Carolina

Contact: Site Public Contact    877-668-0683    cancerclinicaltrials@med.unc.edu  

Principal Investigator: Hanna K. Sanoff        

 

Southeastern Medical Oncology Center-Clinton      

Clinton, North Carolina

Contact: Site Public Contact    919-587-9084    jfields@cancersmoc.com  

Principal Investigator: Samer S. Kasbari        

 

Southeastern Medical Oncology Center-Goldsboro 

Goldsboro, North Carolina

Contact: Site Public Contact    919-587-9084    jfields@cancersmoc.com  

Principal Investigator: Samer S. Kasbari    

   

Margaret R Pardee Memorial Hospital         

Hendersonville, North Carolina

Contact: Site Public Contact    828-696-4716    karen.morris@unchealth.unc.edu  

Principal Investigator: James E. Radford        

 

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina

Contact: Site Public Contact    910-587-9084    jfields@cancersmoc.com  

Principal Investigator: Samer S. Kasbari        

 

Vidant Oncology-Kenansville

Kenansville, North Carolina

Contact: Site Public Contact    252-559-2201    Carla.Zimmerman@vidanthealth.com  

Principal Investigator: Misbah U. Qadir        

 

Vidant Oncology-Kinston      

Kinston, North Carolina

Contact: Site Public Contact    252-559-2201    Carla.Zimmerman@vidanthealth.com  

Principal Investigator: Misbah U. Qadir     

  

FirstHealth of the Carolinas-Moore Regional Hospital         

Pinehurst, North Carolina

Contact: Site Public Contact    910-715-3500    jcwilliams@firsthealth.org  

Principal Investigator: Charles S. Kuzma       

 

Wake Forest University Health Sciences       

Winston-Salem, North Carolina

Contact: Site Public Contact    336-713-6771     

Principal Investigator: Caio Max S. Rocha Lima       

 

North Dakota

Sanford Bismarck Medical Center     

Bismarck, North Dakota

Contact: Site Public Contact    701-323-5760    OncologyClinicalTrialsFargo@sanfordhealth.org  

Principal Investigator: Preston D. Steen     

  

Sanford Broadway Medical Center   

Fargo, North Dakota

Contact: Site Public Contact    701-323-5760    OncologyClinicalTrialsFargo@sanfordhealth.org  

Principal Investigator: Preston D. Steen    

   

Sanford Roger Maris Cancer Center  

Fargo, North Dakota

Contact: Site Public Contact    701-234-6161    OncologyClinicalTrialsFargo@sanfordhealth.org  

Principal Investigator: Preston D. Steen     

  

Ohio

Cleveland Clinic Akron General         

Akron, Ohio

Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org  

Principal Investigator: Esther H. Rehmus 

      

Strecker Cancer Center-Belpre         

Belpre, Ohio

Contact: Site Public Contact    800-523-3977    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore        

 

Dayton Physicians LLC-Miami Valley South  

Centerville, Ohio

Contact: Site Public Contact    937-528-2900    clinical.trials@daytonncorp.org  

Principal Investigator: Howard M. Gross      

 

Miami Valley Hospital South 

Centerville, Ohio

Contact: Site Public Contact    937-528-2900    clinical.trials@daytonncorp.org  

Principal Investigator: Howard M. Gross    

   

Adena Regional Medical Center        

Chillicothe, Ohio

Contact: Site Public Contact    877-779-7585    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore        

 

University of Cincinnati/Barrett Cancer Center        

Cincinnati, Ohio

Contact: Site Public Contact    513-558-4553    uchealthnews@uc.edu  

Principal Investigator: Jordan Kharofa         

 

Cleveland Clinic Cancer Center/Fairview Hospital    

Cleveland, Ohio

Contact: Site Public Contact    866-223-8100    TaussigResearch@ccf.org  

Principal Investigator: Mark K. Kyei        

 

Ohio State University Comprehensive Cancer Center          

Columbus, Ohio

Contact: Site Public Contact    800-293-5066    Jamesline@osumc.edu  

Principal Investigator: John L. Hays    

   

Mount Carmel East Hospital 

Columbus, Ohio

Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore      

 

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio

Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore    

   

Riverside Methodist Hospital

Columbus, Ohio

Contact: Site Public Contact    614-566-4475    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore     

  

Grant Medical Center

Columbus, Ohio

Contact: Site Public Contact    614-566-4475    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore       

 

The Mark H Zangmeister Center       

Columbus, Ohio

Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore     

  

Mount Carmel Health Center West  

Columbus, Ohio

Contact: Site Public Contact    614-234-5433    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore   

    

Doctors Hospital       

Columbus, Ohio

Contact: Site Public Contact    614-566-3275    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore   

    

Miami Valley Hospital

Dayton, Ohio

Contact: Site Public Contact    937-528-2900    clinical.trials@daytonncorp.org  

Principal Investigator: Howard M. Gross        

 

Delaware Health Center-Grady Cancer Center         

Delaware, Ohio

Contact: Site Public Contact    740-615-0227    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore    

   

Grady Memorial Hospital      

Delaware, Ohio

Contact: Site Public Contact    740-615-2403    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore  

     

Greater Dayton Cancer Center          

Kettering, Ohio

Contact: Site Public Contact    937-528-2900    clinical.trials@daytonncorp.org  

Principal Investigator: Howard M. Gross  

     

Fairfield Medical Center        

Lancaster, Ohio

Contact: Site Public Contact    740-687-8863    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore

        

OhioHealth Mansfield Hospital         

Mansfield, Ohio

Contact: Site Public Contact    419-526-8018    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore        

 

Cleveland Clinic Cancer Center Mansfield    

Mansfield, Ohio

Contact: Site Public Contact    866-223-8100    TaussigResearch@ccf.org  

Principal Investigator: Mark K. Kyei        

 

Marietta Memorial Hospital 

Marietta, Ohio

Contact: Site Public Contact    800-523-3977    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore  

     

OhioHealth Marion General Hospital

Marion, Ohio

Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore 

      

Hillcrest Hospital Cancer Center       

Mayfield Heights, Ohio

Contact: Site Public Contact    866-223-8100    TaussigResearch@ccf.org   

Principal Investigator: Mark K. Kyei 

      

Knox Community Hospital    

Mount Vernon, Ohio

Contact: Site Public Contact    740-393-9000    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore      

 

Licking Memorial Hospital    

Newark, Ohio

Contact: Site Public Contact    740-348-4000    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore     

  

Southern Ohio Medical Center         

Portsmouth, Ohio

Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore   

    

North Coast Cancer Care       

Sandusky, Ohio

Contact: Site Public Contact    866-223-8100    TaussigResearch@ccf.org  

Principal Investigator: Mark K. Kyei       

 

ProMedica Flower Hospital  

Sylvania, Ohio

Contact: Site Public Contact    419-824-1842     

Principal Investigator: Feng Jiang 

      

South Pointe Hospital

Warrensville Heights, Ohio

Contact: Site Public Contact    866-223-8100    TaussigResearch@ccf.org  

Principal Investigator: Mark K. Kyei  

     

University Pointe       

West Chester, Ohio

Contact: Site Public Contact       clinicaltrials@ucphysicians.com  

Principal Investigator: Jordan Kharofa      

 

Saint Ann's Hospital  

Westerville, Ohio

Contact: Site Public Contact    614-234-5433    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore     

  

Genesis Healthcare System Cancer Care Center       

Zanesville, Ohio

Contact: Site Public Contact    740-454-5232    sheree@columbusccop.org  

Principal Investigator: Timothy D. Moore     

  

Oklahoma

Cancer Centers of Southwest Oklahoma Research  

Lawton, Oklahoma

Contact: Site Public Contact    877-231-4440     

Principal Investigator: Susanna V. Ulahannan     

  

University of Oklahoma Health Sciences Center      

Oklahoma City, Oklahoma

Contact: Site Public Contact    405-271-8777    ou-clinical-trials@ouhsc.edu  

Principal Investigator: Susanna V. Ulahannan   

    

Cancer Treatment Centers of America          

Tulsa, Oklahoma

Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org  

Principal Investigator: Asha Karippot        

 

Oklahoma Cancer Specialists and Research Institute-Tulsa 

Tulsa, Oklahoma

Contact: Site Public Contact    918-505-3200     

Principal Investigator: Susanna V. Ulahannan    

   

Oregon

Providence Cancer Institute Clackamas Clinic          

Clackamas, Oregon

Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org  

Principal Investigator: Krishna C. Alluri 

      

Providence Newberg Medical Center

Newberg, Oregon

Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org  

Principal Investigator: Krishna C. Alluri    

   

Saint Alphonsus Medical Center-Ontario     

Ontario, Oregon

Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org  

Principal Investigator: John M. Schallenkamp  

     

Providence Portland Medical Center

Portland, Oregon

Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org  

Principal Investigator: Krishna C. Alluri        

 

Providence Saint Vincent Medical Center     

Portland, Oregon

Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org  

Principal Investigator: Krishna C. Alluri         

 

http://paPennsylvania

Lehigh Valley Hospital-Cedar Crest   

Allentown, Pennsylvania

Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org  

Principal Investigator: Tareq Al Baghdadi      

 

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania

Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org  

Principal Investigator: Tareq Al Baghdadi  

     

Saint Vincent Hospital

Erie, Pennsylvania

Contact: Site Public Contact    814-452-5000     

Principal Investigator: Amjad Jalil        

 

UPMC Pinnacle Cancer Center/Community Osteopathic Campus   

Harrisburg, Pennsylvania

Contact: Site Public Contact    717-724-6765    klitchfield@PINNACLEHEALTH.org  

Principal Investigator: Anuradha Krishnamurthy  

     

Jefferson Hospital     

Jefferson Hills, Pennsylvania

Contact: Site Public Contact    412-359-3043    ddefazio@wpahs.org  

Principal Investigator: Amjad Jalil    

   

Forbes Hospital         

Monroeville, Pennsylvania

Contact: Site Public Contact    412-858-7746     

Principal Investigator: Amjad Jalil      

 

Allegheny Valley Hospital     

Natrona Heights, Pennsylvania

Contact: Site Public Contact    724-226-7380     

Principal Investigator: Amjad Jalil 

      

Allegheny General Hospital  

Pittsburgh, Pennsylvania

Contact: Site Public Contact    877-284-2000     

Principal Investigator: Amjad Jalil        

 

West Penn Hospital   

Pittsburgh, Pennsylvania

Contact: Site Public Contact    412-578-5000     

Principal Investigator: Amjad Jalil        

 

University of Pittsburgh Cancer Institute (UPCI)       

Pittsburgh, Pennsylvania

Contact: Site Public Contact    412-647-8073     

Principal Investigator: Anuradha Krishnamurthy    

   

Reading Hospital       

West Reading, Pennsylvania

Contact: Site Public Contact    610-988-9323     

Principal Investigator: Terrence P. Cescon    

    

Wexford Health and Wellness Pavilion        

Wexford, Pennsylvania

Contact: Site Public Contact    412-359-3043    ddefazio@wpahs.org  

Principal Investigator: Amjad Jalil        

 

South Carolina

Prisma Health Cancer Institute - Spartanburg          

Boiling Springs, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere       

 

Prisma Health Cancer Institute - Easley        

Easley, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere   

    

Saint Francis Hospital

Greenville, South Carolina

Contact: Site Public Contact    864-603-6213    melissa_beckman@bshsi.org  

Principal Investigator: Robert D. Siegel      

 

Prisma Health Cancer Institute - Butternut  

Greenville, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere        

 

Prisma Health Cancer Institute - Faris           

Greenville, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere        

 

Saint Francis Cancer Center  

Greenville, South Carolina

Contact: Site Public Contact    864-603-6213    melissa_beckman@bshsi.org  

Principal Investigator: Robert D. Siegel        

 

Prisma Health Cancer Institute - Eastside     

Greenville, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere    

   

Prisma Health Cancer Institute - Greer         

Greer, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere    

   

Prisma Health Cancer Institute - Seneca       

Seneca, South Carolina

Contact: Site Public Contact    864-522-2066    kim.williams3@prismahealth.org  

Principal Investigator: Jeffrey K. Giguere  

     

South Dakota

Sanford Cancer Center Oncology Clinic        

Sioux Falls, South Dakota

Contact: Site Public Contact    605-312-3320    OncologyClinicTrialsSF@sanfordhealth.org  

Principal Investigator: Preston D. Steen    

   

Avera Cancer Institute          

Sioux Falls, South Dakota

Contact: Site Public Contact    605-322-3095    OncRegulatory@avera.org  

Principal Investigator: Benjamin M. Solomon  

     

Sanford USD Medical Center - Sioux Falls     

Sioux Falls, South Dakota

Contact: Site Public Contact    605-312-3320    OncologyClinicalTrialsSF@SanfordHealth.org  

Principal Investigator: Preston D. Steen  

     

Tennessee

Wellmont Bristol Regional Medical Center  

Bristol, Tennessee

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone   

    

Baptist Memorial Hospital and Cancer Center-Collierville   

Collierville, Tennessee

Contact: Site Public Contact    901-226-1366    BCCclintrials@bmhcc.org  

Principal Investigator: Shailesh R. Satpute        

 

Regional Cancer Center at Indian Path Community Hospital

Kingsport, Tennessee

Contact: Site Public Contact    423-578-8538    Justin.reynolds@balladhealth.org  

Principal Investigator: Asheesh Shipstone        

 

Wellmont Holston Valley Hospital and Medical Center       

Kingsport, Tennessee

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone       

 

Baptist Memorial Hospital and Cancer Center-Memphis     

Memphis, Tennessee

Contact: Site Public Contact    901-226-1366    BCCclintrials@bmhcc.org  

Principal Investigator: Shailesh R. Satpute 

      

Texas

The Don and Sybil Harrington Cancer Center

Amarillo, Texas

Contact: Site Public Contact    806-212-1985    Gina.Cravey@bsahs.org  

Principal Investigator: Anita Ravipati    

   

Parkland Memorial Hospital 

Dallas, Texas

Contact: Site Public Contact    214-590-5582    canceranswerline@UTSouthwestern.edu  

Principal Investigator: Syed M. Kazmi    

   

UT Southwestern/Simmons Cancer Center-Dallas   

Dallas, Texas

Contact: Site Public Contact    214-648-7097    canceranswerline@UTSouthwestern.edu  

Principal Investigator: Syed M. Kazmi   

    

Houston Methodist Hospital 

Houston, Texas

Contact: Site Public Contact    713-790-2700     

Principal Investigator: Maen Abdelrahim    

   

M D Anderson Cancer Center

Houston, Texas

Contact: Site Public Contact    877-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: Michael J. Overman        

 

Utah

Huntsman Cancer Institute/University of Utah        

Salt Lake City, Utah

Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu  

Principal Investigator: Heloisa P. Soares    

   

Vermont

Norris Cotton Cancer Center-North  

Saint Johnsbury, Vermont

Contact: Site Public Contact    802-473-4100     

Principal Investigator: Kathryn C. Hourdequin   

    

Virginia

Wellmont Medical Associates-Bristol

Bristol, Virginia

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone        

 

Kaiser Permanente-Burke Medical Center   

Burke, Virginia

Contact: Site Public Contact       Diane.Fisher@nsmtp.kp.org  

Principal Investigator: Leon C. Hwang        

 

Augusta Health Center for Cancer and Blood Disorders      

Fishersville, Virginia

Contact: Site Public Contact    540-332-5960     

Principal Investigator: Kelvin B. Raybon        

 

Centra Lynchburg Hematology-Oncology Clinic Inc  

Lynchburg, Virginia

Contact: Site Public Contact    434-200-5925    Kevin.Patel@centrahealth.com  

Principal Investigator: Khalid Matin        

 

Southwest VA Regional Cancer Center         

Norton, Virginia

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone

       

VCU Massey Cancer Center at Stony Point   

Richmond, Virginia

Contact: Site Public Contact    804-628-1939    mwellons@vcu.edu  

Principal Investigator: Khalid Matin      

 

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia

Contact: Site Public Contact    804-628-1914    klcampbell@vcu.edu  

Principal Investigator: Khalid Matin      

 

VCU Community Memorial Health Center   

South Hill, Virginia

Contact: Site Public Contact    434-774-2442    sherman.baker@vcuhealth.org  

Principal Investigator: Khalid Matin    

   

Washington

Swedish Cancer Institute-Issaquah   

Issaquah, Washington

Contact: Site Public Contact    206-215-3086    PCRC-NCORP@Swedish.org  

Principal Investigator: Krishna C. Alluri     

  

Jefferson Healthcare 

Port Townsend, Washington

Contact: Site Public Contact    360-344-3091     

Principal Investigator: Nicholas DiBella      

 

Swedish Medical Center-First Hill     

Seattle, Washington

Contact: Site Public Contact    206-215-3086    PCRC-NCORP@Swedish.org  

Principal Investigator: Krishna C. Alluri        

 

West Virginia

West Virginia University Charleston Division

Charleston, West Virginia

Contact: Site Public Contact    304-388-9944     

Principal Investigator: Steven J. Jubelirer 

      

Wisconsin

Langlade Hospital and Cancer Center

Antigo, Wisconsin

Contact: Site Public Contact    715-623-9869    Juli.Alford@aspirus.org  

Principal Investigator: Harish G. Ahuja    

   

ThedaCare Regional Cancer Center  

Appleton, Wisconsin

Contact: Site Public Contact    920-364-3605    ResearchDept@thedacare.org  

Principal Investigator: Xin Yao        

 

Ascension Saint Elizabeth Hospital   

Appleton, Wisconsin

Contact: Site Public Contact    414-635-6420    AWRI.inquiry@ascension.org  

Principal Investigator: Kamal Kant Singh Abbi

        

Duluth Clinic Ashland

Ashland, Wisconsin

Contact: Site Public Contact    218-786-3308    CancerTrials@EssentiaHealth.org  

Principal Investigator: Bret E. Friday  

     

Ascension Southeast Wisconsin Hospital - Elmbrook Campus         

Brookfield, Wisconsin

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas   

    

Marshfield Medical Center-EC Cancer Center          

Eau Claire, Wisconsin

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah       

 

Ascension Saint Francis - Reiman Cancer Center      

Franklin, Wisconsin

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas        

 

Bellin Memorial Hospital      

Green Bay, Wisconsin

Contact: Site Public Contact    920-435-8326     

Principal Investigator: Hassan I. Tahsildar        

 

Mercyhealth Hospital and Cancer Center - Janesville          

Janesville, Wisconsin

Contact: Site Public Contact    608-756-6871    oncologyclinicaltrials@mhemail.org  

Principal Investigator: Emily G. Robinson    

   

UW Cancer Center Johnson Creek    

Johnson Creek, Wisconsin

Contact: Site Public Contact    920-699-3500    lynda.persico@uwmf.wisc.edu  

Principal Investigator: Daniel L. Mulkerin   

    

Gundersen Lutheran Medical Center

La Crosse, Wisconsin

Contact: Site Public Contact    608-775-2385    cancerctr@gundersenhealth.org  

Principal Investigator: Kurt Oettel        

 

University of Wisconsin Hospital and Clinics

Madison, Wisconsin

Contact: Site Public Contact    800-622-8922     

Principal Investigator: Daniel L. Mulkerin      

 

Aspirus Medford Hospital     

Medford, Wisconsin

Contact: Site Public Contact    715-847-2353    Beth.Knetter@aspirus.org  

Principal Investigator: Harish G. Ahuja       

 

Marshfield Clinic-Minocqua Center  

Minocqua, Wisconsin

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah 

      

ProHealth D N Greenwald Center     

Mukwonago, Wisconsin

Contact: Site Public Contact       research.institute@phci.org  

Principal Investigator: Timothy R. Wassenaar      

 

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin

Contact: Site Public Contact    262-928-7878     

Principal Investigator: Timothy R. Wassenaar   

    

Ascension Mercy Hospital     

Oshkosh, Wisconsin

Contact: Site Public Contact    920-831-8900    Dale.grimmer@ascension.org  

Principal Investigator: Kamal Kant Singh Abbi    

   

Ascension All Saints Hospital

Racine, Wisconsin

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas  

     

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah      

 

Marshfield Clinic Stevens Point Center         

Stevens Point, Wisconsin

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah        

 

ProHealth Waukesha Memorial Hospital     

Waukesha, Wisconsin

Contact: Site Public Contact    262-928-7632     

Principal Investigator: Timothy R. Wassenaar  

     

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin

Contact: Site Public Contact    262-928-5539    Chanda.miller@phci.org  

Principal Investigator: Timothy R. Wassenaar      

 

Aspirus Regional Cancer Center        

Wausau, Wisconsin

Contact: Site Public Contact    877-405-6866     

Principal Investigator: Harish G. Ahuja      

 

Ascension Medical Group Southeast Wisconsin - Mayfair Road      

Wauwatosa, Wisconsin

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas     

  

Marshfield Medical Center - Weston

Weston, Wisconsin

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah         

 

Aspirus Cancer Care - Wisconsin Rapids       

Wisconsin Rapids, Wisconsin

Contact: Site Public Contact    715-422-7718     

Principal Investigator: Harish G. Ahuja 

      

Wyoming

Cheyenne Regional Medical Center-West    

Cheyenne, Wyoming

Contact: Site Public Contact    303-777-2663    ccrp@co-cancerresearch.org  

Principal Investigator: Nicholas DiBella        

Study Contact Information:

For additional information, please contact:

Principal Investigator:   Caio M

 

This Study is Open To:

Men or women age 18 years or older can participate if they:  

  • Have metastatic colon or rectal cancer without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer
  • Tumor determined to be mismatch-repair deficient (dMMR); patients with MSI-H diagnosis are also eligible
  • Have no immediate need for surgical intervention
This Study is Not Open To:

Patients will be excluded if they:  

  • Have central nervous system (CNS) metastases (Contact the study team to review a list of exceptions)
  • Have uncontrolled high blood pressure
  • Have a severe cardiac condition
  • Have a serious or non-healing wound, skin ulcer, or bone fracture
  • Have a history of transient ischemic attack (TIA), cerebrovascular accident (CVA), gastrointestinal (GI) perforation or blood clot within 6 months prior to study enrollment
  • Have had prior treatment with anti-PD-1, or anti-PD-L1 therapy
  • Have clinically significant liver disease
  • Have a history or risk of autoimmune disease (Contact the study team to review a list of exceptions)
  • Have a history of lung tissue inflammation or lung disease
  • Have known active tuberculosis (TB)
  • Women who are pregnant