Enroll in Research > Research Search & Enroll Tool > Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Clinicaltrials.gov identifier:
NCT02912559

Treatment:
Colorectal

Study Contact Information:

For additional information, please contact: Principal Investigator: Frank A Sinicrope, Alliance for Clinical Trials in Oncology


Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

About the Study

Immunotherapy may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This phase III trial is for people with stage 3 colon cancer. The study will compare how well treatment with a combination of chemotherapy agents and an immunotherapy agent works compared with treatment with combination chemotherapy agents alone. This study is focused on patients who have a biomarker known as MSI-High or dMMR, which are commonly seen in people with Lynch syndrome

Type of Study

The study is an open-label, 2-arm, randomized study.   

  • There will be two treatment groups in this study. One group will receive combination chemotherapy along with the drug atezolizumab.  The other group will receive combination chemotherapy alone.
  • The study is randomized; participants will be placed into one of the two study groups by chance.
  • The study is open-label. All participating patients will know which of the two groups they have been assigned to and which treatments they are being given. 

What the Study Entails

People will be assigned randomly to one of two groups:

Group 1: Chemotherapy and immunotherapy

  • People in this group will receive combination chemotherapy intravenously (oxaliplatin, leucovorin calcium and fluorouracil) on day 1, then continuously over 46 hours on days 1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.
  • Patients also receive atezolizumab IV starting on day 1 of cycle 1 or 2. Treatment repeats every 14 days for up to 25 cycles in the absence of disease progression or unacceptable toxicity.

Group 2: Chemotherapy only

  • People in this group will receive combination chemotherapy intravenously (oxaliplatin, leucovorin calcium, and fluorouracil) on day 1, then continuously over 46 hours on days 1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

Both groups of participants will be followed for up to 5 years.

Study Sites

Alaska Arizona California Colorado Connecticut
Delaware DC Florida Georgia Hawaii
Idaho Illinois Indiana Iowa Kansas
Kentucky Louisiana Maine Maryland Massachusetts
Michigan Minnesota Missouri Montana Nevada
New Hampshire New Jersey New Mexico New York North Carolina
North Dakota Ohio Oklahoma Oregon Pennsylvania
Rhode Island South Carolina South Dakota Tennessee Texas
Utah Virginia Washington West Virginia Wisconsin


Alaska 

  • Anchorage: Katmai Oncology Group; Contact: 907-212-6871 or email    

  Arizona

  • Tucson: Banner University Medical Center - Tucson; Contact by email   
  • Tucson: University of Arizona Cancer Center-North Campus; Contact: 800-327-2873

California

  • Anaheim: Kaiser Permanente-Anaheim; Contact: 800-398-3996 or email
  • Arroyo Grande: PCR Oncology; Contact: 702-384-0013 or email
  • Auburn: Sutter Auburn Faith Hospital; Contact: 415-209-2686 or email
  • Baldwin Park: Kaiser Permanente-Baldwin Park;Contact: 800-398-3996 or email
  • Bellflower: Kaiser Permanente-Bellflower; Contact: 800-398-3996 or email  
  • Berkeley: Alta Bates Summit Medical Center-Herrick Campus; Contact: 415-209-2686 or email 
  • Clovis: University Oncology Associates; Contact: 559-256-9680     
  • Dublin: Epic Care-Dublin; Contact: 925-875-1677
  • Emeryville: Epic Care Partners in Cancer Care; Contact: 510-629-6682     
  • Fontana: Kaiser Permanente-Fontana; Contact: 800-398-3996 or email
  • Fremont: Palo Alto Medical Foundation-Fremont; Contact by email
  • Harbor City: Kaiser Permanente - Harbor City; Contact: 800-398-3996 or email     
  • Irvine: Kaiser Permanente-Irvine; Contact: 800-398-3996 or  or email  
  • Los Angeles:Kaiser Permanente Los Angeles Medical Center; Contact: 800-398-3996 or email 
  • Los Angeles County-USC Medical Center; Contact: 323-865-0451
  • Los Angeles: USC / Norris Comprehensive Cancer Center; Contact: 323-865-0451 
  • Los Angeles: Kaiser Permanente-Cadillac; Contact: 800-398-3996 or email
  • Martinez: Contra Costa Regional Medical Center; Contact: 925-957-5400
  • Marysville: Fremont - Rideout Cancer Center; Contact: 530-749-4400 
  • Modesto: Memorial Medical Center; Contact: 415-209-2686 or email
  • Mountain View: Palo Alto Medical Foundation-Camino Division; Contact: 415-209-2686 or email   
  • Ontario: Kaiser Permanente-Ontario; Contact: 800-398-3996  or email
  • Orange: UC Irvine Health/Chao Family Comprehensive Cancer Center; Contact: 877-827-8839 or email    
  • Palo Alto: Palo Alto Medical Foundation Health Care; Contact: 415-209-2686 or email
  • Palo Alto: Stanford Cancer Institute Palo Alto; Contact: 650-498-7061 or email  
  • Palo Alto: VA Palo Alto Health Care System; Contact: 800-455-0057
  • Panorama City: Kaiser Permanente - Panorama City; Contact: 800-398-3996 or email
  • Riverside: Kaiser Permanente - Riverside; Contact: 800-398-3996 or email
  • Roseville: Sutter Roseville Medical Center; Contact: 415-209-2686 or email
  • Sacramento: Sutter Medical Center Sacramento; Contact: 415-209-2686 or email 
  • Sacramento: University of California Davis Comprehensive Cancer Center; Contact: 916-734-3089
  • Salinas: Salinas Valley Memorial; Contact: 831-759-1838 or email
  • San Diego: Kaiser Permanente-San Diego Zion; Contact: 800-398-3996 or email
  • San Diego: Sharp Memorial Hospital; Contact: 858-939-5062 or email
  • San Francisco: California Pacific Medical Center-Pacific Campus; Contact:  415-209-2686 or email  
  • San Marcos: Kaiser Permanente-San Marcos; Contact: 800-398-3996 or email
  • Santa Cruz: Palo Alto Medical Foundation-Santa Cruz; Contact: Site Public Contact: 415-209-2686 or email  
  • Sunnyvale: Palo Alto Medical Foundation-Sunnyvale; Contact: Site Public Contact: 415-209-2686 or email  
  • Vellego:  Sutter Solano Medical Center/Cancer Center; Contact: Site Public Contact: 415-209-2686 or email  
  • Woodland Hills: Kaiser Permanente-Woodland Hills; Contact: 800-398-3996 or email

Colorado

  • Aurora: Rocky Mountain Cancer Centers-Aurora; Contact: 303-777-2663 or email     
  • Aurora: University of Colorado Hospital; Contact:720-848-0650 
  • Boulder: Boulder Community Hospital; Contact 303-777-2663 or email
  • Boulder: Rocky Mountain Cancer Centers-Boulder; Contact 303-777-2663 or email
  • Colorado Springs: Penrose-Saint Francis Healthcare; Contact: 308-398-6518 or email
  • Colorado Springs: UCHealth Memorial Hospital Central; Contact: 719-365-2406
  • Colorado Springs: Memorial Hospital North; Contact: 719-364-6700
  • Denver: Kaiser Permanente-Franklin; Contact: 303-764-5056 or email 
  • Denver: National Jewish Health-Main Campus; Contact: 877-225-5654 or email   
  • Denver: Rocky Mountain Cancer Centers-Midtown; Contact: 303-777-2663 or email
  • Denver: SCL Health Saint Joseph Hospital; Contact: 303-777-2663 or email 
  • Denver: Rocky Mountain Cancer Centers-Rose; Contact: 303-777-2663 or email
  • Englewood: Swedish Medical Center; Contact: 303-777-2663 or email
  • Englewood: Mountain Blue Cancer Care Center - Swedish; Contact: 303-777-2663 or email
  • Fort Collins: Poudre Valley Hospital; Contact: 970-297-6150        
  • Fort Collins: Cancer Care and Hematology-Fort Collins; Contact: 888-823-5923 or email
  • Golden: National Jewish Health-Western Hematology Oncology; Contact: 303-777-2663 or email  
  • Grand Junction:Saint Mary's Hospital and Regional Medical Center; Contact: 303-777-2663 or email
  • Greeley: North Colorado Medical Center; Contact: 303-777-2663 or email   
  • Greeley: UCHealth Greeley Hospital;Contact: 888-823-5923 or email   
  • Lafayette: Good Samaritan Medical Center; Contact: 303-673-1622        
  • Lafayette: Kaiser Permanente-Rock Creek; Contact: 303-764-5056 or email 
  • Littleton: Rocky Mountain Cancer Centers-Littleton; Contact: 303-777-2663 or email  
  • Lone Tree: Kaiser Permanente-Lone Tree; Contact: 303-764-5056 or email 
  • Lone Tree: Rocky Mountain Cancer Centers-Sky Ridge; Contact: 303-777-2663 or email
  • Longmont: Longmont United Hospital; Contact: 308-398-6518 or email    
  • Loveland: Medical Center of the Rockies; Contact: 970-203-7083    
  • Loveland: McKee Medical Center; Contact: 303-777-2663 or email        
  • Thornton: National Jewish Health-Northern Hematology Oncology; Contact: 303-777-2663  or email    
  • Wheat Ridge: SCL Health Lutheran Medical Center; Contact: 303-777-2663  or email       

Connecticut

  • Derby: Smilow Cancer Hospital-Derby Care Center; Contact: 203-785-5702 or email
  • Fairfield: Smilow Cancer Hospital Care Center-Fairfield; Contact:  203-785-5702  or email  
  • Guildford: Smilow Cancer Hospital Care Center - Guiford; Contact: 203-785-5702  or email  
  •  Hartford: Smilow Cancer Hospital Care Center at Saint Francis; Contact: 203-785-5702  or email  
  • Middletown: Middlesex Hospital; Contact: 860-358-2058 or email   
  • New Haven: Yale University; Contact: 203-785-5702  or email 
  • North Haven: Yale-New Haven Hospital North Haven Medical Center; Contact: 203-785-5702  or email  
  • Torrington: Smilow Cancer Hospital-Torrington Care Center ;Contact: 203-785-5702  or email  
  • Trumbull: Smilow Cancer Hospital Care Center-Trumbull; Contact: 203-785-5702 or email   
  •  Waterbury: Smilow Cancer Hospital-Waterbury Care Center; Contact: 203-785-5702 or email 
  •  Waterford: Smilow Cancer Hospital-Waterford Care Center; Contact: 203-785-5702 or email 

Delaware

  • Frankford: Beebe South Coastal Health Campus; Contact: 302-645-3100 or email      
  • Newark: Helen F Graham Cancer Center; Contact: 302-623-4450 or email           
  • Newark: Medical Oncology Hematology Consultants PA; Contact: 302-623-4450 or email      
  • Rehoboth Beach: Beebe Health Campus; Contact: 302-645-3100 or email    

District of Columbia

  • Sibley Memorial Hospital; Contact: 202-243-2373 or email         

Florida

  • Aventura: Mount Sinai Comprehensive Cancer Center at Aventura; Contact: 305-674-2625 or email        
  • Daytona Beach: Halifax Health Medical Center-Centers for Oncology; Contact: 386-254-4211     
  • Fort Lauderdale: Broward Health Medical Center; Contact: 954-355-5346         
  • Fort Myers: Regional Cancer Center-Lee Memorial Health System; Contact: 773-702-9171 or email     
  • Miami Beach: Mount Sinai Medical Center; Contact:305-674-2625 or email    
  • Orlando: AdventHealth Orlando; Contact: 407-303-2090 or email        

Georgia

  • Albany: Phoebe Putney Memorial Hospital Contact:    229-312-0405 or email    
  • Athens: University Cancer and Blood Center LLC; Contact: 706-353-5006 or email    
  • Augusta: Augusta Oncology Associates PC-D'Antignac; Contact: 706-821-2944  
  • Augusta: Augusta Oncology Associates PC-Wheeler; Contact: 706-736-1830        

Hawaii

  • 'Aiea: Pali Momi Medical Center; Contact: 808-486-6000        
  • Honolulu: Queen's Cancer Cenrer - POB I; Contact: 808-532-0315
  • Honolulu: Queen's Medical Center; Contact: 808-545-8548     
  • Honolulu: Straub Clinic and Hospital; Contact: 808-522-4333    
  • Honolulu: Queen's Cancer Center - Kuakini; Contact: 808-531-8521    

Idaho

  • Boise: Saint Alphonsus Cancer Care Center-Boise; Contact: 734-712-3671 or email     
  • Boise: Saint Luke's Mountain States Tumor Institute; Contact: 208-381-2774 or email     
  • Caldwell: Saint Alphonsus Cancer Care Center-Caldwell; Contact: 734-712-3671 or email     
  • Coeur d'Alene: Kootenai Medical Center; Contact: 406-969-6060 or email      
  • Fruitland: Saint Luke's Cancer Institute - Fruitland; Contact: 208-381-2774 or email      
  • Meridian: Saint Luke's Cancer Institute - Meridian; Contact: 208-381-2774 or email      
  • Nampa: Saint Alphonsus Medical Center-Nampa; Contact: 734-712-3671 or email     
  • Nampa: Saint Luke's Cancer Institute - Nampa; Contact: 208-381-2774 or email     
  • Post Falls: Kootenai Cancer Center; Contact: 406-969-6060 or email     
  • Sandpoint: Kootenai Cancer Center; Contact: 406-969-6060 or email      
  • Twin Falls:Saint Luke's Cancer Institute - Twin Falls; Contact: 208-381-2774 or email    

Illinois

  • Bloomington: Illinois CancerCare-Bloomington; Contact:  309-243-3605 or email        
  • Canton: Illinois CancerCare-Canton; Contact:  309-243-3605 or email       
  • Carterville: SIH Cancer Institute; Contact: 618-985-3333 or email     
  • Carthage: Illinois CancerCare-Carthage; Contact:  309-243-3605 or email       
  • Centralia: Centralia Oncology Clinic; Contact: 217-876-4740 or email       
  • Chicago: Northwestern University; Contact: 312-695-1301 or email     
  • Chicago: Rush University Medical Center; Contact : 312-942-5498 or email       
  • Crystal Lake: AMG Crystal Lake - Oncology; Contact: Site Public Contact    630-929-6129  or email      
  • Decatur: Cancer Care Specialists of Illinois - Decatur; Contact: 217-876-4740 or email       
  • Dixon: Illinois CancerCare-Dixon; Contact    815-285-7800      
  • Eureka: Illinois CancerCare-Eureka; Contact 309-243-3605  or email      
  • Evanston: NorthShore University HealthSystem-Evanston Hospital; Contact: 847-570-2109     
  • Freeport: Freeport Memorial Hospital/Leonard C Ferguson Cancer Center; Contact: 815-599-7000     
  • Galesburg: Illinois CancerCare-Galesburg; Contact: 309-243-3605    andersonj@illinoiscancercare.com
  • Geneva: Northwestern Medicine Cancer Center Delnor; Contact: 630-352-5360    Donald.Smith3@nm.org  
  • Glenview: NorthShore University HealthSystem-Glenbrook Hospital; Contact: 847-570-2109
  • Harvey:Ingalls Memorial Hospital; Contact: 708-915-4673    clinicaltrials@ingalls.org  
  • Highland Park: NorthShore University HealthSystem-Highland Park Hospital: Contact: 847-570-2109  
  • Kewanee: Illinois CancerCare-Kewanee Clinic; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Lake Forest: Northwestern Medicine Lake Forest Hospital: Contact: cancertrials@northwestern.edu
  • Libertyville: AMG Libertyville - Oncology; Contact: 630-929-6129    advocateresearch@advocatehealth.com  
  • Macomb: Illinois CancerCare-Macomb; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Maywood: Loyola University Medical Center; Contact: 708-226-4357     
  • Mount Vernon: Good Samaritan Regional Health Center; Contact:    618-242-4600
  • O'Fallon: Cancer Care Center of O'Fallon; Contact    217-876-4762    morganthaler.jodi@mhsil.com  
  • Ottawa: Illinois CancerCare-Ottawa Clinic; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Park Ridge: Advocate Lutheran General Hospital; Contact: 847-384-3621
  • Pekin: Illinois CancerCare-Pekin; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Peoria: Illinois CancerCare-Peoria; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Peru: Illinois CancerCare-Peru; Contact: 309-243-3605    andersonj@illinoiscancercare.com  
  • Princeton: Illinois CancerCare-Princeton; Contact: 309-243-3605    andersonj@illinoiscancercare.com
  • Silvis: Genesis Cancer Center - Silvis; Contact: 563-421-1908    turnerk@genesishealth.com
  • Springfield: Southern Illinois University School of Medicine; Contact: 217-545-7929     
  • Springfield: Springfield Clinic; Contact: 800-444-7541
  • Warrenville: Northwestern Medicine Cancer Center Warrenville; Contact: 630-352-5360    Donald.Smith3@nm.org  

Indiana

  • Indianapolis: Indiana University/Melvin and Bren Simon Cancer Center; Contact: 317-278-5632    iutrials@iu.edu
  • Indianapolis: Sidney and Lois Eskenazi Hospital Contact    317-278-5632    iutrials@iu.edu
  • Indianapolis: Franciscan Health Indianapolis; Contact: 317-528-7060     
  • Mooresville: Franciscan Health Mooresville; Contact: 317-834-3603
  • Richmond: Reid Health; Contact: 937-528-2900    clinical.trials@daytonncorp.org
  • Terre Haute: Union Hospital; Contact: 812-238-7394     

Iowa

  • Ames: Mary Greeley Medical Center; Contact: 515-956-4132
  • Ames: McFarland Clinic PC - Ames; Contact: 515-239-4734    ksoder@mcfarlandclinic.com
  • Bettendorf: University of Iowa Healthcare Cancer Services Quad Cities; Contact: 563-355-7733    kedaprile@rccqc.com
  • Boone: McFarland Clinic PC-Boone; Contact: 515-956-4132
  • Cedar Rapids: Mercy Hospital; Contact: 319-365-4673
  • Cedar Rapids: Oncology Associates at Mercy Medical Center; Contact    319-363-2690     
  • Clive: Medical Oncology and Hematology Associates-West Des Moines; Contact: 308-398-6518 clinicaltrials@sfmc-gi.org  
  • Clive: Mercy Cancer Center-West Lakes; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org  
  • Davenport: Genesis Medical Center - East Campus; Contact: 563-421-1908    turnerk@genesishealth.com 
  • Davenport: Iowa Cancer Specialists; Contact: 563-421-1908    turnerk@genesishealth.com
  • Des Moines: Iowa Methodist Medical Center; Contact: 515-241-6727 
  • Des Moines: Medical Oncology and Hematology Associates-Des Moines; Contact: 515-282-2921 
  • Des Moines: Broadlawns Medical Center; Contact: 515-282-2200
  • Des Moines: Medical Oncology and Hematology Associates-Laurel; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org 
  • Des Moines: Mercy Medical Center - Des Moines; Contact: 308-398-6518  clinicaltrials@sfmc-gi.org
  • Fort Dodge: McFarland Clinic PC-Trinity Cancer Center; Contact : 515-956-4132     
  • Iowa City: University of Iowa/Holden Comprehensive Cancer Center; Contact: 800-237-1225     
  • Jefferson: McFarland Clinic PC-Jefferson; Contact: 515-956-4132
  • Marshalltown: McFarland Clinic PC-Marshalltown; Contact: 515-956-4132     
  • Sioux City: Siouxland Regional Cancer Center; Contact: 712-252-9326    HoopingarnerT@jencc.com  
  • West Des Moines: Mercy Medical Center-West Lakes; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org    

Kansas

  • Hays: HaysMed University of Kansas Health System
  • Kansas City:University of Kansas Cancer Center-West; Contact: 913-588-3671 or email      
  • Liberal: Cancer Center of Kansas-Liberal; Contact: 316-268-5374 or email
  • Olathe: Olathe Health Cancer Center; Contact: 913-355-8000    Jeni.wakefield@olathehealth.org  
  • Overland Park: University of Kansas Cancer Center-Overland Park; Contact: 913-588-3671    KUCC_Navigation@kumc.edu  
  • Pittsburg: Ascension Via Christi - Pittsburg; Contact: 620-235-7900    jennifer.jameson@ascension.org
  • Salina: Salina Regional Health Center;  Contact: 785-452-7038    mleepers@srhc.com
  • Topeka: University of Kansas Health System Saint Francis Campus; Contact: 785-295-8000   
  • Westwood: University of Kansas Hospital-Westwood Cancer Center; Contact: 913-588-3671    KUCC_Navigation@kumc.edu
  • Wichita: Cancer Center of Kansas-Wichita Medical Arts Tower; Contact: 316-268-5374    Keisha.humphries@ascension.org  

Kentucky

  • Edgewood: Saint Elizabeth Medical Center South; Contact: 859-301-5473    darla.hehman@stelizabeth.com  
  • Fort Thomas: Saint Elizabeth Fort Thomas; Contact    859-301-9418
  • Lexington: Baptist Health Lexington; Contact: 859-260-6425
  • Lexington: Saint Joseph Hospital East; Contact:  308-398-6518    clinicaltrials@sfmc-gi.org 
  • Lexington: University of Kentucky/Markey Cancer Center; Contact: 859-257-3379     

Louisiana

  • Baton Rouge: LSU Health Baton Rouge-North Clinic; Contact: 225-215-1353    clinicalresearch@marybird.com
  • Baton Rouge: Louisiana Hematology Oncology Associates LLC; Contact: 225-215-1353    clinicalresearch@marybird.com  
  • Baton Rouge: Mary Bird Perkins Cancer Center; Contact: 225-215-1353    clinicalresearch@marybird.com  
  • Baton Rouge: Our Lady of the Lake - Medical Oncology; Contact: 225-215-1353    clinicalresearch@marybird.com  
  • Kenner: Ochsner Medical Center Kenner; Contact: 504-464-8314    cris.molina@ochsner.org     
  • New Orleans: Ochsner Medical Center Jefferson; Contact: 504-703-8712    Gregory.Johnstone@ochsner.org  

Maine

  • Augusta: Harold Alfond Center for Cancer Care; Contact: 207-626-4855     
  • Belfast: Waldo County General Hospital; Contact: 207-338-2500     
  • Biddeford:  MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford; Contact       LLemire@mmc.org 
  • Brewer: Lafayette Family Cancer Center-EMMC; Contact:    800-987-3005     
  • Rockport: Penobscot Bay Medical Center; Contact: 207-396-8670    ClinicalResearch@mmc.org  
  • Sanford: MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford; Contact  LLemire@mmc.org 
  • South Portland: Maine Medical Partners - South Portland; Contact: 207-396-8670    ClinicalResearch@mmc.org  

Maryland

  • Baltimore: Saint Agnes Hospital; Contact: 410-368-2910     
  • Baltimore: Johns Hopkins University/Sidney Kimmel Cancer Center; Contact: 410-955-8804    jhcccro@jhmi.edu  
  • Glen Burnie: UM Baltimore Washington Medical Center/Tate Cancer Center; Contact: 410-553-8100          

Massachusetts

  • Boston: Boston Medical Center; Contact: 617-638-8265     
  • Boston: Beth Israel Deaconess Medical Center; Contact: 617-667-9925     
  • Boston: Dana-Farber Cancer Institute; Contact: 877-442-3324       

Michigan

  • Ann Arbor: Saint Joseph Mercy Hospital; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Battle Creek: Bronson Battle Creek; Contact: 616-391-1230    crcwm-regulatory@crcwm.org          
  • Bay City: McLaren Cancer Institute-Bay City; Contact: 313-576-9790    ctoadmin@karmanos.org 
  • Bloomfield: McLaren Cancer Institute-Bloomfield; Contact: 313-576-9790    ctoadmin@karmanos.org  
  • Brighton: IHA Hematology Oncology Consultants-Brighton; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Brighton: Saint Joseph Mercy Brighton; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Brownstown: Henry Ford Cancer Institute-Downriver; Contact: 313-916-3721    CTOResearch@hfhs.org
  • Canton: IHA Hematology Oncology Consultants-Canton; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Canton: Saint Joseph Mercy Canton; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Chelsea: IHA Hematology Oncology Consultants-Chelsea; Contact: 734-712-3671 or email  
  • Chelsea: Saint Joseph Mercy Chelsea; Contact: 734-712-3671 or email   
  • Clarkston: Hematology Oncology Consultants-Clarkston; Contact: 734-712-3671 or email      
  • Clarkston: McLaren Cancer Institute-Clarkston; Contact: 313-576-9790 or email  
  • Dearborn: Beaumont Hospital-Dearborn; Contact: 248-551-7695
  • Dearborn: Henry Ford Medical Center-Fairlane; Contact: 313-916-3721 or email
  • Detroit:Wayne State University/Karmanos Cancer Institute; Contact: 313-576-9790 or email 
  • Detroit: Henry Ford Hospital; Contact: 313-916-3721 or email
  • East China Township: Great Lakes Cancer Management Specialiists - Doctors Park; Contact: 734-712-3671 or email 
  • Farmington Hills: Weisberg Cancer Treatment Center; Contact: 313-576-9790 or email
  • Flint: McLaren Cancer Institute-Flint; ; Contact: 313-576-9790 or by email 
  • Flint: Genessee Cancer and Blood Disease Center: Contact: 734-712-3671 or email          
  • Flint: Singh and Arora Hematology Oncology PC; Contact: 313-576-9790 or email 
  • Grand Rapids: Spectrum Health at Butterworth Campus; Contact: 616-391-1230 or email
  • Grosse Point Woods: Academic Hematology Oncology Specialists; Contact: 734-712-3671 or email  
  • Grosse Point Woods: Great Lakes Cancer Management Specialists-Van Elslander Cancer Center; Contact: 734-712-3671 or email   
  • Jackson: Allegiance Health; Contact: 313-916-3721 or by email
  • Kalamazoo: West Michigan Cancer Center; Contact: 616-391-1230 or email
  • Lansing: McLaren-Greater Lansing; Contact: 313-576-9790 or email  
  • Lansing: Sparrow Hospital; Contact: 734-712-3671 or email  
  • Lapeer: McLaren Cancer Institute-Lapeer Region; Contact: 313-576-9790 or email 
  • Livonia: Hope Cancer Clinic; Contact: 734-712-3671 or email    
  • Livonia: Saint Mary Mercy Hospital; Contact: 734-712-3671 or email  
  • Mount Clemens: McLaren Cancer Institute-Macomb; Contact: 313-576-9790 or email       
  • Mount Pleasant: McLaren Cancer Institute-Central Michigan; Contact: 313-576-9790 or email  
  • Novi: Henry Ford Medical Center-Columbus; Contact: 313-916-3721 or by email        
  • Petoskey: McLaren Cancer Institute-Northern Michigan; Contact: 313-576-9790 or email          
  • Pontiac: Saint Joseph Mercy Oakland; Contact: 734-712-3671 or email   
  • Port Huron: McLaren-Port Huron; Contact: 313-576-9790 or email 
  • Royal Oak: William Beaumont Hospital-Royal Oak; Contact: 248-551-7695  
  • Saginaw: Ascension Saint Mary's Hospital; Contact: 734-712-3671 or email     
  • Southfield: Ascension Providence Hospitals - Southfield; Contact: 248-849-5332 or email      
  • Tawas City: Ascension Saint Joseph Hospital; Contact: 734-712-3671 or email   
  • Traverse City: Munson Medical Center; Contact: 616-391-1230 or email
  • Troy: William Beaumont Hospital-Troy; Contact: 248-551-7695
  • Warren: Great Lakes Cancer Management Specialists-Macomb Professional Building; Contact: 734-712-3671 or email 
  • West Bloomfield: Henry Ford West Bloomfield Hospital; Contact: 313-916-3721 or by email 
  • West Branch: Saint Mary's Oncology/Hematology Associates of West Branch; Contact: 734-712-3671 or email 
  • Ypsilanti: IHA Hematology Oncology Consultants-Ann Arbor; Contact: 734-712-3671 or email

Minnesota

  • Albert Lea: Mayo Clinic Health System in Albert Lea; Contact: 855-776-0015
  • Bemidji: Sanford Joe Lueken Cancer Center; Contact: 218-333-5000    OncologyClinicalTrialsFargo@sanfordhealth.org   
  • Burnsville: Fairview Ridges Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com 
  • Coon Rapids: Mercy Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Deer River: Essentia Health - Deer River Clinic; Contact: 218-786-3308    CancerTrials@EssentiaHealth.org  
  • Duluth: Essentia Health Cancer Center; Contact: 218-786-3308    CancerTrials@EssentiaHealth.org  
  • Edina: Fairview Southdale Hospital; Contact:    952-993-1517    mmcorc@healthpartners.com  
  • Fridley: Unity Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Hibbing: Essentia Health Hibbing Clinic; Contact: 218-786-3308     
  • Mankato: Mayo Clinic Health Systems-Mankato; Contact: 855-776-0015     
  • Maplewood: Minnesota Oncology Hematology PA-Maplewood; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Maplewood: Saint John's Hospital - Healtheast; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Minneapolis: Abbott-Northwestern Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Minneapolis: Hennepin County Medical Center; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Minneapolis: Health Partners; Contact: 952-993-1517    mmcorc@healthpartners.com
  • Rochester: Mayo Clinic in Rochester; Contact: 855-776-0015     
  • Saint Cloud: Coborn Cancer Center at Saint Cloud Hospital; Contact: 877-229-4907    coborncancercenter@centracare.com  
  • Saint Louis Park: Park Nicollet Clinic - Saint Louis Park; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Saint Paul: Regions Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Saint Paul: United Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Sandstone: Essentia Health Sandstone; Contact    218-786-3308    CancerTrials@EssentiaHealth.org
  • Stillwater: Lakeview Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Virginia: Essentia Health Virginia Clinic; Contact: 218-786-3308    CancerTrials@EssentiaHealth.org
  • Waconia: Ridgeview Medical Center; Waconia, Minnesota, 55387
  • Wilmar: Rice Memorial Hospital; Contact: 952-993-1517    mmcorc@healthpartners.com  
  • Woodbury: Minnesota Oncology Hematology PA-Woodbury; Contact: 952-993-1517    mmcorc@healthpartners.com  

Missouri

  • Ballwin: Saint Louis Cancer and Breast Institute-Ballwin; Contact: 314-251-7058     
  • Cape Girardeau: Saint Francis Medical Center; Contact: 573-334-2230    sfmc@sfmc.net
  • Cape Girardeau: Southeast Cancer Center; Contact: 573-651-5550
  • Columbia: University of Missouri - Ellis Fischel; Contact: 573-882-7440
  • Creve Coeur: Siteman Cancer Center at West County Hospital; Contact: 800-600-3606    info@siteman.wustl.edu
  • Joplin: Mercy Hospital Joplin; Contact: 417-556-3074    esmeralda.carrillo@mercy.net        
  • Kansas City: Truman Medical Centers; Contact: 816-404-4375     
  • Kansas City: University of Kansas Cancer Center - North; Contact: 913-588-3671    KUCC_Navigation@kumc.edu  
  • Lee's Summit: University of Kansas Cancer Center - Lee's Summit; Contact: 913-588-3671    KUCC_Navigation@kumc.edu  
  • Saint Louis: Washington University School of Medicine; Contact: 800-600-3606    info@siteman.wustl.edu  
  • Saint Louis: Siteman Cancer Center-South County; Contact: 800-600-3606    info@siteman.wustl.edu  
  • Saint Louis: Missouri Baptist Medical Center; Contact: 314-996-5569     
  • Saint Louis: Siteman Cancer Center at Christian Hospital; Contact: 800-600-3606    info@siteman.wustl.edu  
  • Saint Peters: Siteman Cancer Center at Saint Peters Hospital; Contact: 800-600-3606    info@siteman.wustl.edu  
  • Sainte Genevieve: Sainte Genevieve County Memorial Hospital; Contact: 314-996-5569     
  • Springfield: Mercy Hospital Springfield; Contact: 417-269-4520      
  • Sullivan: Missouri Baptist Sullivan Hospital; Contact: 314-996-5569     
  • Sunset Hills: Missouri Baptist Outpatient Center-Sunset Hills; Contact: 314-996-5569     

Montana

  • Anaconda: Community Hospital of Anaconda; Contact: 406-969-6060    mccinfo@mtcancer.org  
  • Billings: Billings Clinic Cancer Center; Contact    800-996-2663    research@billingsclinic.org 
  • Bozeman: Bozeman Deaconess Hospital; Contact: 406-969-6060    mccinfo@mtcancer.org 
  • Great Falls: Benefis Healthcare- Sletten Cancer Institute; Contact: 406-969-6060    mccinfo@mtcancer.org
  • Kalispell: Kalispell Regional Medical Center; Contact: 406-969-6060    mccinfo@mtcancer.org
  • Missoula: Community Medical Hospital; Contact    406-969-6060    mccinfo@mtcancer.org   

Nebraska

  • Grand Island: CHI Health Saint Francis; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org  
  • Kearney: CHI Health Good Samaritan; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org  
  • Omaha: Nebraska Methodist Hospital; Contact: 402-354-5144     
  • Omaha: Nebraska Medicine-Village Pointe; Contact: 402-559-5600     
  • Omaha: Alegent Health Bergan Mercy Medical Center; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org    
  • Omaha: University of Nebraska Medical Center; Contact: 402-559-6941    unmcrsa@unmc.edu    

Nevada

  • Henderson: OptumCare Cancer Care at Seven Hills; Contact: 702-384-0013    research@sncrf.org
  • Las Vegas: OptumCare Cancer Care at Oakey/MountainView and Fort Apache; Contact    702-384-0013    research@sncrf.org  
  • Reno: Renown Regional Medical Center; Contact: 702-384-0013    research@sncrf.org  

New Hampshire

  • Concord: New Hampshire Oncology Hematology PA-Concord; Contact: 603-224-2556
  • Exeter: Exeter Hospital; Contact    800-439-3837
  • Lebanon: Dartmouth Hitchcock Medical Center; Contact: 800-639-6918    cancer.research.nurse@dartmouth.edu 
  • Manchester: Solinsky Center for Cancer Care; Contact: 800-339-6484     

New Jersey

  • Basking Ridge: Memorial Sloan Kettering Basking Ridge; Contact: 212-639-7592     
  • Egg Harbor Township: AtlantiCare Surgery Center; Contact    609-748-7200 
  • Hamilton: The Cancer Institute of New Jersey Hamilton; Contact: 609-631-6946
  • Middletown:  Memorial Sloan Kettering Monmouth; Contact:   212-639-7592
  • Montvale: Memorial Sloan Kettering Bergen; Contact: 212-639-7592
  • Morristown: Morristown Medical Center; Contact: 973-971-5900
  • Mulica Hill: Inspira Medical Center Mullica Hill; Contact: 856-508-3500    DeNigrisJ@ihn.org
  • New Brunswick: Rutgers Cancer Institute of New Jersey; Contact: 732-235-7356
  • Newark: Newark Beth Israel Medical Center; Contact: 973-926-7230    Christine.Kosmides@rwjbh.org 
  • Paramus:  The Valley Hospital-Luckow Pavilion; Contact: 201-634-5792
  • Somerville:Robert Wood Johnson University Hospital Somerset; Contact: 908-685-2481  Siby.Varughese@rwjbh.org    

New Mexico

  • Albuquerque: University of New Mexico Cancer Center; Contact: 505-925-0366    LByatt@nmcca.org
  • Albuquerque: Presbyterian Kaseman Hospital; Contact: 505-559-6113    WBurman@phs.org
  • Rio Rancho: Presbyterian Rust Medical Center/Jorgensen Cancer Center; Contact: 505-559-6113    WBurman@phs.org   

New York

  • Auburn: Hematology Oncology Associates of Central New York-Auburn; Contact: 315-472-7504
  • Brooklyn: Maimonides Medical Center; Contact: 718-765-2500 
  • Buffalo: Roswell Park Cancer Institute; Contact: 800-767-9355    askroswell@roswellpark.org
  • Commack: Memorial Sloan Kettering Commack; Contact: 212-639-7592
  • Cooperstown: Mary Imogene Bassett Hospital; Contact    877-547-1750   CancerClinicalTrials@bassett.org     
  • East Hills: Cancer Institute at Saint Francis Hospital; Contact: 773-702-9171    protocols@AllianceNCTN.org  
  • East Syracuse: Hematology Oncology Associates of Central New York-East Syracuse; Contact: 315-472-7504     
  • Elmira: Arnot Ogden Medical Center/Falck Cancer Center; Contact: 607-271-7000
  • Harrison: Memorial Sloan Kettering Westchester; Contact: 212-639-7592
  • New York: Mount Sinai West;  Contact: 212-824-7309    CCTO@mssm.edu     
  • New York: NYP/Columbia University Medical Center; Contact: 212-305-6361    nr2616@cumc.columbia.edu      
  • New York: Memorial Sloan Kettering Cancer Center: Contact    212-639-7592
  • New York: NYP/Weill Cornell Medical Center; Contact: 212-746-1848 
  • Stony Brook: Stony Brook University Medical Center; Contact: 800-862-2215     
  • Syracuse: State University of New York Upstate Medical University; Contact    315-464-5476
  • Syracuse: Hematology Oncology Associates of Central New York-Onondaga Hill; Contact    315-472-7504
  • Uniondale: Memorial Sloan Kettering Nassau; Contact: 212-639-7592       
  • White Plains: Dickstein Cancer Treatment Center; Contact: 914-849-7582    mcortese@wphospital.org  

North Carolina

  • Albemarle: Atrium Health Stanly/LCI-Albemarle; Contact: 800-804-9376
  • Asheboro: Randolph Hospital; Contact: 336-832-0836    vivian.sheidler@conehealth.com
  • Asheville: AdventHealth Infusion Center Asheville; Contact: 828-650-8037    AMBER.WHEELER@AdventHealth.com  
  • Burlington: Cone Health Cancer Center at Alamance Regional; Contact: 336-538-7725    kaye.shoffner@conehealth.com 
  • Charlotte: Carolinas Medical Center/Levine Cancer Institute; Contact: 800-804-9376
  • Charlotte: Atrium Health Pineville/LCI-Pineville; Contact: 980-442-2000
  • Charlotte: Levine Cancer Institute-SouthPark; Contact: 980-442-2000
  • Charlotte: Levine Cancer Institute-Ballantyne; Contact: 800-804-9376
  • Clinton: Southeastern Medical Oncology Center-Clinton; Contact: 919-587-9084    jfields@cancersmoc.com
  • Clyde: AdventHealth Infusion Center Haywood; Contact: 828-650-8037  AMBER.WHEELER@AdventHealth.com
  • Concord: Atrium Health Cabarrus/LCI-Concord; Contact: 800-804-9376 
  • Durham: Duke University Medical Center; Contact    888-275-3853
  • Gastonia: Levine Cancer Institute-Gaston; Contact: 800-804-9376
  • Goldsboro: Southeastern Medical Oncology Center-Goldsboro; Contact: 919-587-9084    jfields@cancersmoc.com 
  • Greensboro: Cone Health Cancer Center; Contact: 336-832-0821    vivian.sheidler@conehealth.com
  • Greenville: East Carolina University; Contact  252-744-1015 eubankss@ecu.edu  
  • Hendersonville: Margaret R Pardee Memorial Hospital; Contact: 828-696-4716    karen.morris@unchealth.unc.edu
  • Hendersonville: AdventHealth Hendersonville; Contact: 828-650-8037  AMBER.WHEELER@AdventHealth.com
  • Jacksonville: Southeastern Medical Oncology Center-Jacksonville; Contact    910-587-9084    jfields@cancersmoc.com
  • Kenansville: Vidant Oncology-Kenansville; Contact: 252-559-2201    Carla.Zimmerman@vidanthealth.com  
  • Kinston: Vidant Oncology-Kinston; Contact    252-559-2201    Carla.Zimmerman@vidanthealth.com  
  • Lincolnton: Atrium Health Lincoln/LCI-Lincolnton; Contact: 800-804-9376
  • Monroe: Atrium Health Union/LCI-Union; Contact:   980-442-2000
  • Shelby: Atrium Health Cleveland/LCI-Cleveland; Contact: 800-804-9376 
  • Washington: Marion L Shepard Cancer Center at Vidant Beaufort Hospital                 

North Dakota

  • Bismark: Sanford Bismarck Medical Center; Contact: 701-323-5760    OncologyClinicalTrialsFargo@sanfordhealth.org
  • Fargo:  Sanford Broadway Medical Center; Contact: 701-323-5760      
  • Fargo:  Sanford Roger Maris Cancer Center; Contact    701-234-6161
  • Minot: Trinity Cancer Care Center; Contact: 800-862-0005

Ohio

  • Beavercreek: Indu and Raj Soin Medical Center; Contact:  937-528-2900    clinical.trials@daytonncorp.org
  • Belpre:  Strecker Cancer Center-Belpre; Contact: 800-523-3977    sheree@columbusccop.org   
  • Canton: Mercy Medical Center; Contact: 888-293-4673     
  • Canton: Aultman Health Foundation; Contact: 330-363-7274           
  • Centerville: Miami Valley Hospital South; Contact: 937-528-2900    clinical.trials@daytonncorp.org  
  • Cincinnati: Good Samaritan Hospital – Cincinnati; Contact: 308-398-6518    clinicaltrials@sfmc-gi.org
  • Cleveland: Cleveland Clinic Cancer Center/Fairview Hospital; Contact    866-223-8100    TaussigResearch@ccf.org  
  • Columbus: Ohio State University Comprehensive Cancer Center; Contact:  800-293-5066    Jamesline@osumc.edu  
  • Columbus: Columbus Oncology and Hematology Associates; Contact: 614-488-2118    sheree@columbusccop.org  
  • Columbus:  Grant Medical Center; Contact    614-566-4475    sheree@columbusccop.org
  • Columbus:   The Mark H Zangmeister Center ; Contact: 614-488-2118    sheree@columbusccop.org  
  • Columbus: Doctors Hospital; Contact: 614-566-3275    sheree@columbusccop.org  
  • Dayton: Dayton Physician-Miami Valley Hospital North; Contact:  937-528-2900    clinical.trials@daytonncorp.org  
  • Delaware: Delaware Health Center-Grady Cancer Center; Contact: 740-615-0227    sheree@columbusccop.org  
  • Mansfield: OhioHealth Mansfield Hospital; Contact    419-526-8018    sheree@columbusccop.org  
  • Mansfield: Cleveland Clinic Cancer Center Mansfield; Contact: 866-223-8100    TaussigResearch@ccf.org
  • Marietta:  Marietta Memorial Hospital; Contact    800-523-3977    sheree@columbusccop.org  
  • Marion: OhioHealth Marion General Hospital; Contact: 614-488-2118    sheree@columbusccop.org  
  • Mayfield Heights: Hillcrest Hospital Cancer Center; Contact    866-223-8100    TaussigResearch@ccf.org
  • Newark: Licking Memorial Hospital; Contact: 740-348-4000    sheree@columbusccop.org  
  • Portsmouth: Southern Ohio Medical Center; Contact: 614-488-2118    sheree@columbusccop.org  
  • Sandusky: North Coast Cancer Care; Contact: 866-223-8100    TaussigResearch@ccf.org 
  • Strongsville:  Cleveland Clinic Cancer Center Strongsville; Contact: 866-223-8100    TaussigResearch@ccf.org  
  • Syvania: ProMedica Flower Hospital; Contact:  419-824-1842     
  • Toledo: Toledo Clinic Cancer Centers-Toledo; Contact: 800-444-3561     
  • Warrensville Heights: South Pointe Hospital; Contact: 866-223-8100 TaussigResearch@ccf.org  
  • Wooster: Cleveland Clinic Wooster Family Health and Surgery Center; Contact: 866-223-8100 TaussigResearch@ccf.org
  • Youngstown: Saint Elizabeth Youngstown Hospital; Contact: 937-528-2900    clinical.trials@daytonncorp.org 
  • Zanesville: Genesis Healthcare System Cancer Care Center; Contact: 740-454-5232  sheree@columbusccop.org      

Oklahoma

  • Lawton: Cancer Centers of Southwest Oklahoma Research; Contact: 877-231-4440          
  • Oklahoma City: University of Oklahoma Health Sciences Center; Contact: 405-271-8777    ou-clinical-trials@ouhsc.edu  
  • Oklahoma City: Mercy Hospital Oklahoma City; Contact: 405-752-3402     
  • Tulsa: Oklahoma Cancer Specialists and Research Institute-Tulsa; Contact: 918-505-3200     

Oregon

  • Clackamas: Providence Cancer Institute Clackamas Clinic; Contact: 503-215-2614    CanRsrchStudies@providence.org  
  • Newberg: Providence Newberg Medical Center; Contact: 503-215-2614    CanRsrchStudies@providence.org    
  • Ontario: Saint Alphonsus Medical Center-Ontario; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org  
  • Portland: Providence Portland Medical Center; Contact: 503-215-2614    CanRsrchStudies@providence.org        
  • Portland: Providence Saint Vincent Medical Center; Contact: 503-215-2614    CanRsrchStudies@providence.org  

Pennsylvania

  • Allentown: Lehigh Valley Hospital-Cedar Crest; Contact: 734-712-3671    stephanie.couch@stjoeshealth.org      
  • BethlehemSaint Luke's University Hospital-Bethlehem; Contact: 484-503-4151   
  • Bethlehem: Lehigh Valley Hospital - Muhlenberg; Contact:734-712-3671    stephanie.couch@stjoeshealth.org    
  • Bryn Mawr: Bryn Mawr Hospital; Contact: 484-476-2649    turzoe@mlhs.org
  • Chambersburg: Chambersburg Hospital: Contact    773-702-9171    protocols@AllianceNCTN.org  
  • Danville: Geisinger Medical Center; Contact: 570-271-5251    HemonCCTrials@geisinger.edu      
  • Ephrata: Ephrata Cancer Center; Contact: 717-721-4840     
  • Gettysburg: Adams Cancer Center; Contact: 877-441-7957     
  • Harrisburg: UPMC Pinnacle Cancer Center/Community Osteopathic Campus; Contact: 717-724-6765    klitchfield@PINNACLEHEALTH.org
  • Hazleton: Geisinger Medical Center-Cancer Center Hazleton; Contact : 570-459-2901    HemonCCTrials@geisinger.edu
  • Jefferson Hills:Jefferson Hospital; Contact: 412-359-3043    ddefazio@wpahs.org   
  • Lebanon: Sechler Family Cancer Center; Contact: 717-741-8303    doxenberg@wellspan.org  
  • Lewisburg: Geisinger Medical Oncology-Lewisburg; Contact: 570-374-8555    HemonCCTrials@geisinger.edu
  • Media: Riddle Memorial Hospital; Contact: 484-476-2649    turzoe@mlhs.org
  • Monroeville: Forbes Hospital; Contact: 412-858-7746     
  • Natrona Heights: Allegheny Valley Hospital; Contact: 724-226-7380     
  • Paoli: Paoli Memorial Hospital: Contact    484-476-2649    turzoe@mlhs.org  
  • Philadelphia: Temple University Hospital; Contact :  215-728-2983     
  • Pittsburgh: Allegheny General Hospital; Contact : 877-284-2000       
  • Pittsburgh: West Penn Hospital; Contact: 412-578-5000          
  • Pittsburgh: University of Pittsburgh Cancer Institute (UPCI); Contact: 412-647-8073      
  • Pottsville: Geisinger Cancer Services-Pottsville; Contact: 800-275-6401    HemonCCTrials@geisinger.edu  
  • Sayre: Guthrie Medical Group PC-Robert Packer Hospital; Contact:  800-836-0388     
  • Scranton: Community Medical Center; Contact : 570-703-4768    HemonCCTrials@geisinger.edu 
  • West Reading: Reading Hospital; Contact: 610-988-9323     
  • Wilkes-Barre: Geisinger Wyoming Valley/Henry Cancer Center; Contact: 570-271-5251    HemonCCTrials@geisinger.edu   
  • Willow Grove: Abington Memorial Hospital-Asplundh Cancer Pavilion; Contact: 215-481-2402
  • Wynnewood: Lankenau Medical Center; Contact: 484-476-2649    turzoe@mlhs.org
  • York: WellSpan Health-York Cancer Center; Contact    877-441-7957        

Rhode Island

  • Providence: Rhode Island Hospital; Contact: 401-444-1488     

South Carolina

  • Anderson: AnMed Health Cancer Center; Contact: 864-512-4651    rhonda.ballew@anmedhealth.org
  • Boiling Springs: Prisma Health Cancer Institute - Spartanburg; Contact : 864-522-2066    kim.williams3@prismahealth.org 
  • Easley: Prisma Health Cancer Institute - Easley; Contact: 864-522-2066    kim.williams3@prismahealth.org  
  • Greenville: Saint Francis Hospital; Contact: 864-603-6213    melissa_beckman@bshsi.org  
  • Greenville: Prisma Health Cancer Institute - Butternut; Contact : 864-522-2066    kim.williams3@prismahealth.org  
  • Greenville: Prisma Health Cancer Institute - Faris; Contact    864-522-2066    kim.williams3@prismahealth.org          
  • Greer: Prisma Health Cancer Institute - Greer; Contact:  864-522-2066    kim.williams3@prismahealth.org  
  • Rock Hill: Levine Cancer Institute-Rock Hill; Contact:  800-804-9376         
  • Seneca: Prisma Health Cancer Institute - Seneca; Contact : 864-522-2066    kim.williams3@prismahealth.org  
  • Spartanburg: Spartanburg Medical Center      

South Dakota

  • Rapid City: Rapid City Regional Hospital; Contact: 605-716-3982    research@rcrh.org  
  • Sioux Falls: Sanford Cancer Center Oncology Clinic; Contact: 605-312-3320    OncologyClinicTrialsSF@sanfordhealth.org  
  • Sioux Falls: Avera Cancer Institute; Contact: 605-322-3095    OncRegulatory@avera.org  
  • Sioux Falls: Sanford USD Medical Center - Sioux Falls; Contact: 605-312-3320    OncologyClinicalTrialsSF@SanfordHealth.org       

Tennessee

  • Kingsport: Regional Cancer Center at Indian Path Community Hospital; Contact: 423-578-8538    Justin.reynolds@balladhealth.org  
  • Knoxville: Thompson Cancer Survival Center; Contact: 865-331-1812          
  • Lenoir City: Thompson Oncology Group-Lenoir City; Contact: 865-331-1812     
  • Oak Ridge: Thompson Oncology Group-Oak Ridge; Contact: 865-331-1812     

Texas

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106

Contact: Site Public Contact    806-212-1985    gcravey@harringtoncc.org  

Principal Investigator: Anita Ravipati  

     

Dell Seton Medical Center at The University of Texas          

Austin, Texas, 78701

Contact: Site Public Contact    512-324-7991     

Principal Investigator: Om N. Pandey 

      

MD Anderson in The Woodlands      

Conroe, Texas, 77384

Contact: Site Public Contact    866-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: George J. Chang

       

Parkland Memorial Hospital 

Dallas, Texas, 75235

Contact: Site Public Contact    214-590-5582    canceranswerline@UTSouthwestern.edu  

Principal Investigator: Syed M. Kazmi        

 

UT Southwestern/Simmons Cancer Center-Dallas   

Dallas, Texas, 75390

Contact: Site Public Contact    214-648-7097    canceranswerline@UTSouthwestern.edu  

Principal Investigator: Syed M. Kazmi       

 

M D Anderson Cancer Center

Houston, Texas, 77030

Contact: Site Public Contact    877-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: George J. Chang  

     

MD Anderson West Houston

Houston, Texas, 77079

Contact: Site Public Contact    877-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: George J. Chang        

 

MD Anderson League City     

League City, Texas, 77573

Contact: Site Public Contact    877-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: George J. Chang

       

Scott and White Healthcare Round Rock       Active, not recruiting

Round Rock, Texas, 78665

 

MD Anderson in Sugar Land  

Sugar Land, Texas, 77478

Contact: Site Public Contact    877-632-6789    askmdanderson@mdanderson.org  

Principal Investigator: George J. Chang      

 

Scott and White Memorial Hospital  Active, not recruiting

Temple, Texas, 76508

 

Utah

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

Contact: Site Public Contact    801-855-4100    officeofresearch@imail.org  

Principal Investigator: Ramya Thota      

 

Sandra L Maxwell Cancer Center      

Cedar City, Utah, 84720

Contact: Site Public Contact    435-868-5680    officeofresearch@imail.org  

Principal Investigator: Ramya Thota     

  

Farmington Health Center    

Farmington, Utah, 84025

Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu  

Principal Investigator: Glynn W. Gilcrease     

  

Logan Regional Hospital        

Logan, Utah, 84321

Contact: Site Public Contact    435-716-6400    officeofresearch@imail.org  

Principal Investigator: Ramya Thota   

    

Utah Valley Regional Medical Center

Provo, Utah, 84604

Contact: Site Public Contact    801-357-7965    officeofresearch@imail.org  

Principal Investigator: Ramya Thota    

   

Dixie Medical Center Regional Cancer Center          

Saint George, Utah, 84770

Contact: Site Public Contact    435-688-4167    officeofresearch@imail.org  

Principal Investigator: Ramya Thota        

 

Huntsman Cancer Institute/University of Utah        

Salt Lake City, Utah, 84112

Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu  

Principal Investigator: Glynn W. Gilcrease  

     

Virginia

Wellmont Medical Associates-Bristol

Bristol, Virginia, 24201

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone 

      

University of Virginia Cancer Center 

Charlottesville, Virginia, 22908

Contact: Site Public Contact    434-243-6303    PAS9E@virginia.edu  

Principal Investigator: Tri M. Le 

      

Centra Lynchburg Hematology-Oncology Clinic Inc  

Lynchburg, Virginia, 24501

Contact: Site Public Contact    434-200-5925    Kevin.Patel@centrahealth.com  

Principal Investigator: Khalid Matin       

 

Sovah Health Martinsville     

Martinsville, Virginia, 24115

Contact: Site Public Contact    276-666-7489    sharon.hubbard@lpnt.net  

Principal Investigator: Mohammed Saad    

   

Bon Secours Memorial Regional Medical Center     

Mechanicsville, Virginia, 23116

Contact: Site Public Contact    804-893-8611    Melissa_Godsey@bshsi.org  

Principal Investigator: William J. Irvin  

     

Bon Secours Saint Francis Medical Center    

Midlothian, Virginia, 23114

Contact: Site Public Contact    804-893-8611    Melissa_Godsey@bshsi.org  

Principal Investigator: William J. Irvin     

  

Southwest VA Regional Cancer Center         

Norton, Virginia, 24273

Contact: Site Public Contact    423-578-8538    justin.reynolds@wellmont.org  

Principal Investigator: Asheesh Shipstone   

    

Bon Secours Saint Mary's Hospital   

Richmond, Virginia, 23226

Contact: Site Public Contact    804-893-8611    Melissa_Godsey@bshsi.org  

Principal Investigator: William J. Irvin     

  

Virginia Cancer Institute       

Richmond, Virginia, 23230

Contact: Site Public Contact    804-287-3000    david.trent@comcast.net  

Principal Investigator: Khalid Matin  

     

VCU Massey Cancer Center at Stony Point   

Richmond, Virginia, 23235

Contact: Site Public Contact    804-628-1939    mwellons@vcu.edu  

Principal Investigator: Khalid Matin      

 

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Contact: Site Public Contact    804-628-1914    klcampbell@vcu.edu  

Principal Investigator: Khalid Matin       

 

VCU Community Memorial Health Center   

South Hill, Virginia, 23970

Contact: Site Public Contact    434-774-2442    sherman.baker@vcuhealth.org  

Principal Investigator: Khalid Matin       

 

Shenandoah Oncology PC     

Winchester, Virginia, 22601

Contact: Site Public Contact    540-662-1108    William.Houck@usoncology.com  

Principal Investigator: Khalid Matin        

 

Washington

Harrison HealthPartners Hematology and Oncology-Bremerton    

Bremerton, Washington, 98310

Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org  

Principal Investigator: Richard L. Deming   

    

Jefferson Healthcare 

Port Townsend, Washington, 98368

Contact: Site Public Contact    360-344-3091     

Principal Investigator: Nicholas DiBella

        

Virginia Mason Medical Center         

Seattle, Washington, 98101

Contact: Site Public Contact    206-342-6954    vmmc.cancer_clinical_research@VirginiaMason.org  

Principal Investigator: Hagen F. Kennecke

       

Seattle Cancer Care Alliance 

Seattle, Washington, 98109

Contact: Site Public Contact    800-804-8824     

Principal Investigator: Stacey A. Cohen       

 

Kaiser Permanente Washington        Active, not recruiting

Seattle, Washington, 98112

 

Swedish Medical Center-First Hill     

Seattle, Washington, 98122-4307

Contact: Site Public Contact    206-215-3086    PCRC-NCORP@Swedish.org  

Principal Investigator: Alison K. Conlin      

 

Seattle Cancer Care Alliance at Northwest Hospital

Seattle, Washington, 98133

Contact: Site Public Contact    206-606-5800     

Principal Investigator: Stacey A. Cohen     

  

West Virginia

United Hospital Center         

Bridgeport, West Virginia, 26330

Contact: Site Public Contact    304-293-7374    cancertrialsinfo@hsc.wvu.edu  

Principal Investigator: Shalu Pahuja    

   

West Virginia University Charleston Division

Charleston, West Virginia, 25304

Contact: Site Public Contact    304-388-9944     

Principal Investigator: Steven J. Jubelirer        

 

Edwards Comprehensive Cancer Center      

Huntington, West Virginia, 25701

Contact: Site Public Contact    304-399-6617     

Principal Investigator: Maria R. Tria Tirona       

 

Wisconsin

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Contact: Site Public Contact    715-623-9869    Juli.Alford@aspirus.org  

Principal Investigator: Harish G. Ahuja        

 

ThedaCare Regional Cancer Center  

Appleton, Wisconsin, 54911

Contact: Site Public Contact    920-364-3605    ResearchDept@thedacare.org  

Principal Investigator: Xin Yao      

 

Duluth Clinic Ashland

Ashland, Wisconsin, 54806

Contact: Site Public Contact    218-786-3308    CancerTrials@EssentiaHealth.org  

Principal Investigator: Bret E. Friday      

 

Ascension Southeast Wisconsin Hospital - Elmbrook Campus         

Brookfield, Wisconsin, 53045

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas   

    

Aurora Cancer Care-Southern Lakes VLCC    

Burlington, Wisconsin, 53105

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel  

     

Marshfield Medical Center-EC Cancer Center          

Eau Claire, Wisconsin, 54701

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah      

 

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, 54701

Contact: Site Public Contact    855-776-0015     

Principal Investigator: Frank A. Sinicrope

        

Aurora Health Center-Fond du Lac   

Fond Du Lac, Wisconsin, 54937

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel    

   

Ascension Saint Francis - Reiman Cancer Center      

Franklin, Wisconsin, 53132

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas   

    

Aurora Health Care Germantown Health Center     

Germantown, Wisconsin, 53022

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel   

    

Aurora Cancer Care-Grafton 

Grafton, Wisconsin, 53024

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel     

  

Saint Vincent Hospital Cancer Center Green Bay      

Green Bay, Wisconsin, 54301

Contact: Site Public Contact    920-433-8889    ewd_research_admin@hshs.org  

Principal Investigator: Anthony J. Jaslowski  

     

Saint Vincent Hospital Cancer Center at Saint Mary's          

Green Bay, Wisconsin, 54303

Contact: Site Public Contact    920-433-8889    ewd_research_admin@hshs.org  

Principal Investigator: Anthony J. Jaslowski     

  

Aurora BayCare Medical Center        

Green Bay, Wisconsin, 54311

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel   

    

Aurora Cancer Care-Kenosha South 

Kenosha, Wisconsin, 53142

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel     

  

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Contact: Site Public Contact    608-775-2385    cancerctr@gundersenhealth.org  

Principal Investigator: Michael O. Ojelabi        

 

Mayo Clinic Health System-Franciscan Healthcare  

La Crosse, Wisconsin, 54601

Contact: Site Public Contact    855-776-0015     

Principal Investigator: Frank A. Sinicrope  

     

Aurora Bay Area Medical Group-Marinette 

Marinette, Wisconsin, 54143

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel       

 

Marshfield Medical Center-Marshfield        

Marshfield, Wisconsin, 54449

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah       

 

Aspirus Medford Hospital     

Medford, Wisconsin, 54451

Contact: Site Public Contact    715-847-2353    Beth.Knetter@aspirus.org  

Principal Investigator: Harish G. Ahuja    

   

Aurora Cancer Care-Milwaukee        

Milwaukee, Wisconsin, 53209

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel     

  

Aurora Saint Luke's Medical Center  

Milwaukee, Wisconsin, 53215

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel    

   

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Contact: Site Public Contact    414-805-3666     

Principal Investigator: James P. Thomas  

     

Aurora Sinai Medical Center 

Milwaukee, Wisconsin, 53233

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel   

    

Marshfield Clinic-Minocqua Center  

Minocqua, Wisconsin, 54548

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah  

     

ProHealth D N Greenwald Center     

Mukwonago, Wisconsin, 53149

Contact: Site Public Contact       research.institute@phci.org  

Principal Investigator: Timothy R. Wassenaar  

     

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com  

Principal Investigator: Daniel M. Anderson      

 

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

Contact: Site Public Contact    262-928-7878     

Principal Investigator: Timothy R. Wassenaar 

      

Saint Vincent Hospital Cancer Center at Oconto Falls          

Oconto Falls, Wisconsin, 54154

Contact: Site Public Contact    920-433-8889    ewd_research_admin@hshs.org  

Principal Investigator: Anthony J. Jaslowski     

  

Vince Lombardi Cancer Clinic - Oshkosh       

Oshkosh, Wisconsin, 54904

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel 

      

Ascension All Saints Hospital

Racine, Wisconsin, 53405

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas

       

Aurora Cancer Care-Racine   

Racine, Wisconsin, 53406

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel    

   

Vince Lombardi Cancer Clinic-Sheboygan    

Sheboygan, Wisconsin, 53081

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel      

 

Marshfield Clinic Stevens Point Center         

Stevens Point, Wisconsin, 54482

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

Principal Investigator: Isaac K. Yeboah    

   

Saint Vincent Hospital Cancer Center at Sturgeon Bay         

Sturgeon Bay, Wisconsin, 54235-1495

Contact: Site Public Contact    920-433-8889    ewd_research_admin@hshs.org  

Principal Investigator: Anthony J. Jaslowski   

    

Aurora Medical Center in Summit    

Summit, Wisconsin, 53066

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel    

   

Vince Lombardi Cancer Clinic-Two Rivers     

Two Rivers, Wisconsin, 54241

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel        

 

ProHealth Waukesha Memorial Hospital     

Waukesha, Wisconsin, 53188

Contact: Site Public Contact    262-928-7632      

Principal Investigator: Timothy R. Wassenaar

       

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

Contact: Site Public Contact    262-928-5539    Chanda.miller@phci.org  

Principal Investigator: Timothy R. Wassenaar    

  

Aspirus Regional Cancer Center        

Wausau, Wisconsin, 54401

Contact: Site Public Contact    877-405-6866     

Principal Investigator: Harish G. Ahuja      

 

Ascension Medical Group Southeast Wisconsin - Mayfair Road      

Wauwatosa, Wisconsin, 53226

Contact: Site Public Contact    414-635-6420    AWRI.Inquiry@Ascension.org  

Principal Investigator: Francis J. Cuevas      

 

Aurora Cancer Care-Milwaukee West           

Wauwatosa, Wisconsin, 53226

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel    

   

Aurora West Allis Medical Center     

West Allis, Wisconsin, 53227

Contact: Site Public Contact    414-302-2304    ncorp@aurora.org  

Principal Investigator: Adam P. Siegel     

  

Marshfield Clinic - Weston Center    

Weston, Wisconsin, 54476

Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org  

     

Aspirus UW Cancer Center    

Wisconsin Rapids, Wisconsin, 54494

Contact: Site Public Contact    715-422-7718     

  

 

This Study is Open To:

Men or women age 18 years or older can participate if they:  

  • Have stage III colon cancer; tumors must originate in the colon
  • Are Lynch syndrome patients having a germline mutation in an MMR gene (EPCAM, MLH1, MSH2, MSH6, PMS2);
  • Have deficient (d) DNA mismatch repair (dMMR)
  • Show no evidence of spread to lymph nodes or metastatic disease
  • Have had no prior medical therapy (chemotherapy, immunotherapy, biologic or targeted therapy) or radiation therapy for the current colon cancer except for one cycle of mFOLFOX6
  • Do not have active known autoimmune disease, including colitis, inflammatory bowel disease, rheumatoid arthritis, panhypopituitarism, adrenal insufficiency
  • Do not have active hepatitis B or C
This Study is Not Open To:

Patients will be excluded if they:  

  • Have active pulmonary disease with hypoxia (low oxygen levels)
  • Are not MSI-High or dMMR
  • Women who are pregnant