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Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

https://www.facingourrisk.org/research-clinical-trials/study/107/combination-chemotherapy-with-or-without-atezolizumab-in-treating-patients-with-stage-iii-colon-cancer-and-deficient-dna-mismatch-repair

Clinicaltrials.gov identifier:
NCT02912559 (https://clinicaltrials.gov/show/NCT02912559)


Study Contact Information:

For additional information, please contact: Principal Investigator: Frank A Sinicrope, Alliance for Clinical Trials in Oncology


About the Study

Immunotherapy may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This phase III trial is for people with stage 3 colon cancer. The study will compare how well treatment with a combination of chemotherapy agents and an immunotherapy agent works compared with treatment with combination chemotherapy agents alone. This study is focused on patients who have a biomarker known as MSI-High or dMMR, which are commonly seen in people with Lynch syndrome. NOTE: This study is no longer enrolling people. 

What the Study Entails

People will be assigned randomly to one of two groups:

Group 1: Chemotherapy and immunotherapy

Group 2: Chemotherapy only

Both groups of participants will be followed for up to 5 years.

Study Sites

Alaska Arizona California Colorado Connecticut
Delaware DC Florida Georgia Hawaii
Idaho Illinois Indiana Iowa Kansas
Kentucky Louisiana Maine Maryland Massachusetts
Michigan Minnesota Missouri Montana Nevada
New Hampshire New Jersey New Mexico New York North Carolina
North Dakota Ohio Oklahoma Oregon Pennsylvania
Rhode Island South Carolina South Dakota Tennessee Texas
Utah Virginia Washington West Virginia Wisconsin


Alaska 

  Arizona

California

Colorado

Connecticut

Delaware

District of Columbia

Florida

Georgia

Hawaii

Idaho

Illinois

Indiana

Iowa

Kansas

Kentucky

Louisiana

Maine

Maryland

Massachusetts

Michigan

Minnesota

Missouri

Montana

Nebraska

Nevada

New Hampshire

New Jersey

New Mexico

New York

North Carolina

North Dakota

Ohio

Oklahoma

Oregon

Pennsylvania

Rhode Island

South Carolina

South Dakota

Tennessee

Texas

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106

Contact: Site Public Contact    806-212-1985    [email protected]  

Principal Investigator: Anita Ravipati  

     

Dell Seton Medical Center at The University of Texas          

Austin, Texas, 78701

Contact: Site Public Contact    512-324-7991     

Principal Investigator: Om N. Pandey 

      

MD Anderson in The Woodlands      

Conroe, Texas, 77384

Contact: Site Public Contact    866-632-6789    [email protected]  

Principal Investigator: George J. Chang

       

Parkland Memorial Hospital 

Dallas, Texas, 75235

Contact: Site Public Contact    214-590-5582    [email protected]  

Principal Investigator: Syed M. Kazmi        

 

UT Southwestern/Simmons Cancer Center-Dallas   

Dallas, Texas, 75390

Contact: Site Public Contact    214-648-7097    [email protected]  

Principal Investigator: Syed M. Kazmi       

 

M D Anderson Cancer Center

Houston, Texas, 77030

Contact: Site Public Contact    877-632-6789    [email protected]  

Principal Investigator: George J. Chang  

     

MD Anderson West Houston

Houston, Texas, 77079

Contact: Site Public Contact    877-632-6789    [email protected]  

Principal Investigator: George J. Chang        

 

MD Anderson League City     

League City, Texas, 77573

Contact: Site Public Contact    877-632-6789    [email protected]  

Principal Investigator: George J. Chang

       

Scott and White Healthcare Round Rock       Active, not recruiting

Round Rock, Texas, 78665

 

MD Anderson in Sugar Land  

Sugar Land, Texas, 77478

Contact: Site Public Contact    877-632-6789    [email protected]  

Principal Investigator: George J. Chang      

 

Scott and White Memorial Hospital  Active, not recruiting

Temple, Texas, 76508

 

Utah

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

Contact: Site Public Contact    801-855-4100    [email protected]  

Principal Investigator: Ramya Thota      

 

Sandra L Maxwell Cancer Center      

Cedar City, Utah, 84720

Contact: Site Public Contact    435-868-5680    [email protected]  

Principal Investigator: Ramya Thota     

  

Farmington Health Center    

Farmington, Utah, 84025

Contact: Site Public Contact    888-424-2100    [email protected]  

Principal Investigator: Glynn W. Gilcrease     

  

Logan Regional Hospital        

Logan, Utah, 84321

Contact: Site Public Contact    435-716-6400    [email protected]  

Principal Investigator: Ramya Thota   

    

Utah Valley Regional Medical Center

Provo, Utah, 84604

Contact: Site Public Contact    801-357-7965    [email protected]  

Principal Investigator: Ramya Thota    

   

Dixie Medical Center Regional Cancer Center          

Saint George, Utah, 84770

Contact: Site Public Contact    435-688-4167    [email protected]  

Principal Investigator: Ramya Thota        

 

Huntsman Cancer Institute/University of Utah        

Salt Lake City, Utah, 84112

Contact: Site Public Contact    888-424-2100    [email protected]  

Principal Investigator: Glynn W. Gilcrease  

     

Virginia

Wellmont Medical Associates-Bristol

Bristol, Virginia, 24201

Contact: Site Public Contact    423-578-8538    [email protected]  

Principal Investigator: Asheesh Shipstone 

      

University of Virginia Cancer Center 

Charlottesville, Virginia, 22908

Contact: Site Public Contact    434-243-6303    [email protected]  

Principal Investigator: Tri M. Le 

      

Centra Lynchburg Hematology-Oncology Clinic Inc  

Lynchburg, Virginia, 24501

Contact: Site Public Contact    434-200-5925    [email protected]  

Principal Investigator: Khalid Matin       

 

Sovah Health Martinsville     

Martinsville, Virginia, 24115

Contact: Site Public Contact    276-666-7489    [email protected]  

Principal Investigator: Mohammed Saad    

   

Bon Secours Memorial Regional Medical Center     

Mechanicsville, Virginia, 23116

Contact: Site Public Contact    804-893-8611    [email protected]  

Principal Investigator: William J. Irvin  

     

Bon Secours Saint Francis Medical Center    

Midlothian, Virginia, 23114

Contact: Site Public Contact    804-893-8611    [email protected]  

Principal Investigator: William J. Irvin     

  

Southwest VA Regional Cancer Center         

Norton, Virginia, 24273

Contact: Site Public Contact    423-578-8538    [email protected]  

Principal Investigator: Asheesh Shipstone   

    

Bon Secours Saint Mary's Hospital   

Richmond, Virginia, 23226

Contact: Site Public Contact    804-893-8611    [email protected]  

Principal Investigator: William J. Irvin     

  

Virginia Cancer Institute       

Richmond, Virginia, 23230

Contact: Site Public Contact    804-287-3000    [email protected]  

Principal Investigator: Khalid Matin  

     

VCU Massey Cancer Center at Stony Point   

Richmond, Virginia, 23235

Contact: Site Public Contact    804-628-1939    [email protected]  

Principal Investigator: Khalid Matin      

 

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Contact: Site Public Contact    804-628-1914    [email protected]  

Principal Investigator: Khalid Matin       

 

VCU Community Memorial Health Center   

South Hill, Virginia, 23970

Contact: Site Public Contact    434-774-2442    [email protected]  

Principal Investigator: Khalid Matin       

 

Shenandoah Oncology PC     

Winchester, Virginia, 22601

Contact: Site Public Contact    540-662-1108    [email protected]  

Principal Investigator: Khalid Matin        

 

Washington

Harrison HealthPartners Hematology and Oncology-Bremerton    

Bremerton, Washington, 98310

Contact: Site Public Contact    308-398-6518    [email protected]  

Principal Investigator: Richard L. Deming   

    

Jefferson Healthcare 

Port Townsend, Washington, 98368

Contact: Site Public Contact    360-344-3091     

Principal Investigator: Nicholas DiBella

        

Virginia Mason Medical Center         

Seattle, Washington, 98101

Contact: Site Public Contact    206-342-6954    [email protected]  

Principal Investigator: Hagen F. Kennecke

       

Seattle Cancer Care Alliance 

Seattle, Washington, 98109

Contact: Site Public Contact    800-804-8824     

Principal Investigator: Stacey A. Cohen       

 

Kaiser Permanente Washington        Active, not recruiting

Seattle, Washington, 98112

 

Swedish Medical Center-First Hill     

Seattle, Washington, 98122-4307

Contact: Site Public Contact    206-215-3086    [email protected]  

Principal Investigator: Alison K. Conlin      

 

Seattle Cancer Care Alliance at Northwest Hospital

Seattle, Washington, 98133

Contact: Site Public Contact    206-606-5800     

Principal Investigator: Stacey A. Cohen     

  

West Virginia

United Hospital Center         

Bridgeport, West Virginia, 26330

Contact: Site Public Contact    304-293-7374    [email protected]  

Principal Investigator: Shalu Pahuja    

   

West Virginia University Charleston Division

Charleston, West Virginia, 25304

Contact: Site Public Contact    304-388-9944     

Principal Investigator: Steven J. Jubelirer        

 

Edwards Comprehensive Cancer Center      

Huntington, West Virginia, 25701

Contact: Site Public Contact    304-399-6617     

Principal Investigator: Maria R. Tria Tirona       

 

Wisconsin

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Contact: Site Public Contact    715-623-9869    [email protected]  

Principal Investigator: Harish G. Ahuja        

 

ThedaCare Regional Cancer Center  

Appleton, Wisconsin, 54911

Contact: Site Public Contact    920-364-3605    [email protected]  

Principal Investigator: Xin Yao      

 

Duluth Clinic Ashland

Ashland, Wisconsin, 54806

Contact: Site Public Contact    218-786-3308    [email protected]  

Principal Investigator: Bret E. Friday      

 

Ascension Southeast Wisconsin Hospital - Elmbrook Campus         

Brookfield, Wisconsin, 53045

Contact: Site Public Contact    414-635-6420    [email protected]  

Principal Investigator: Francis J. Cuevas   

    

Aurora Cancer Care-Southern Lakes VLCC    

Burlington, Wisconsin, 53105

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel  

     

Marshfield Medical Center-EC Cancer Center          

Eau Claire, Wisconsin, 54701

Contact: Site Public Contact    800-782-8581    [email protected]  

Principal Investigator: Isaac K. Yeboah      

 

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, 54701

Contact: Site Public Contact    855-776-0015     

Principal Investigator: Frank A. Sinicrope

        

Aurora Health Center-Fond du Lac   

Fond Du Lac, Wisconsin, 54937

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel    

   

Ascension Saint Francis - Reiman Cancer Center      

Franklin, Wisconsin, 53132

Contact: Site Public Contact    414-635-6420    [email protected]  

Principal Investigator: Francis J. Cuevas   

    

Aurora Health Care Germantown Health Center     

Germantown, Wisconsin, 53022

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel   

    

Aurora Cancer Care-Grafton 

Grafton, Wisconsin, 53024

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel     

  

Saint Vincent Hospital Cancer Center Green Bay      

Green Bay, Wisconsin, 54301

Contact: Site Public Contact    920-433-8889    [email protected]  

Principal Investigator: Anthony J. Jaslowski  

     

Saint Vincent Hospital Cancer Center at Saint Mary's          

Green Bay, Wisconsin, 54303

Contact: Site Public Contact    920-433-8889    [email protected]  

Principal Investigator: Anthony J. Jaslowski     

  

Aurora BayCare Medical Center        

Green Bay, Wisconsin, 54311

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel   

    

Aurora Cancer Care-Kenosha South 

Kenosha, Wisconsin, 53142

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel     

  

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Contact: Site Public Contact    608-775-2385    [email protected]  

Principal Investigator: Michael O. Ojelabi        

 

Mayo Clinic Health System-Franciscan Healthcare  

La Crosse, Wisconsin, 54601

Contact: Site Public Contact    855-776-0015     

Principal Investigator: Frank A. Sinicrope  

     

Aurora Bay Area Medical Group-Marinette 

Marinette, Wisconsin, 54143

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel       

 

Marshfield Medical Center-Marshfield        

Marshfield, Wisconsin, 54449

Contact: Site Public Contact    800-782-8581    [email protected]  

Principal Investigator: Isaac K. Yeboah       

 

Aspirus Medford Hospital     

Medford, Wisconsin, 54451

Contact: Site Public Contact    715-847-2353    [email protected]  

Principal Investigator: Harish G. Ahuja    

   

Aurora Cancer Care-Milwaukee        

Milwaukee, Wisconsin, 53209

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel     

  

Aurora Saint Luke's Medical Center  

Milwaukee, Wisconsin, 53215

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel    

   

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Contact: Site Public Contact    414-805-3666     

Principal Investigator: James P. Thomas  

     

Aurora Sinai Medical Center 

Milwaukee, Wisconsin, 53233

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel   

    

Marshfield Clinic-Minocqua Center  

Minocqua, Wisconsin, 54548

Contact: Site Public Contact    800-782-8581    [email protected]  

Principal Investigator: Isaac K. Yeboah  

     

ProHealth D N Greenwald Center     

Mukwonago, Wisconsin, 53149

Contact: Site Public Contact       [email protected]  

Principal Investigator: Timothy R. Wassenaar  

     

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Contact: Site Public Contact    952-993-1517    [email protected]  

Principal Investigator: Daniel M. Anderson      

 

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

Contact: Site Public Contact    262-928-7878     

Principal Investigator: Timothy R. Wassenaar 

      

Saint Vincent Hospital Cancer Center at Oconto Falls          

Oconto Falls, Wisconsin, 54154

Contact: Site Public Contact    920-433-8889    [email protected]  

Principal Investigator: Anthony J. Jaslowski     

  

Vince Lombardi Cancer Clinic - Oshkosh       

Oshkosh, Wisconsin, 54904

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel 

      

Ascension All Saints Hospital

Racine, Wisconsin, 53405

Contact: Site Public Contact    414-635-6420    [email protected]  

Principal Investigator: Francis J. Cuevas

       

Aurora Cancer Care-Racine   

Racine, Wisconsin, 53406

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel    

   

Vince Lombardi Cancer Clinic-Sheboygan    

Sheboygan, Wisconsin, 53081

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel      

 

Marshfield Clinic Stevens Point Center         

Stevens Point, Wisconsin, 54482

Contact: Site Public Contact    800-782-8581    [email protected]  

Principal Investigator: Isaac K. Yeboah    

   

Saint Vincent Hospital Cancer Center at Sturgeon Bay         

Sturgeon Bay, Wisconsin, 54235-1495

Contact: Site Public Contact    920-433-8889    [email protected]  

Principal Investigator: Anthony J. Jaslowski   

    

Aurora Medical Center in Summit    

Summit, Wisconsin, 53066

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel    

   

Vince Lombardi Cancer Clinic-Two Rivers     

Two Rivers, Wisconsin, 54241

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel        

 

ProHealth Waukesha Memorial Hospital     

Waukesha, Wisconsin, 53188

Contact: Site Public Contact    262-928-7632      

Principal Investigator: Timothy R. Wassenaar

       

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

Contact: Site Public Contact    262-928-5539    [email protected]  

Principal Investigator: Timothy R. Wassenaar    

  

Aspirus Regional Cancer Center        

Wausau, Wisconsin, 54401

Contact: Site Public Contact    877-405-6866     

Principal Investigator: Harish G. Ahuja      

 

Ascension Medical Group Southeast Wisconsin - Mayfair Road      

Wauwatosa, Wisconsin, 53226

Contact: Site Public Contact    414-635-6420    [email protected]  

Principal Investigator: Francis J. Cuevas      

 

Aurora Cancer Care-Milwaukee West           

Wauwatosa, Wisconsin, 53226

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel    

   

Aurora West Allis Medical Center     

West Allis, Wisconsin, 53227

Contact: Site Public Contact    414-302-2304    [email protected]  

Principal Investigator: Adam P. Siegel     

  

Marshfield Clinic - Weston Center    

Weston, Wisconsin, 54476

Contact: Site Public Contact    800-782-8581    [email protected]  

     

Aspirus UW Cancer Center    

Wisconsin Rapids, Wisconsin, 54494

Contact: Site Public Contact    715-422-7718     

  

 


This Study is Open To:

Men or women age 18 years or older can participate if they:  

This Study is Not Open To:

Patients will be excluded if they:  


About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.