XRAYS - Making Sense of Cancer Headlines

FORCE’s eXamining the Relevance of Articles for Young Survivors (XRAYS) program is a reliable resource for breast cancer research-related news and information. XRAYS reviews new breast cancer research, provides plain-language summaries, and rates how the media covered the topic. XRAYS is funded by the CDC.

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Screening

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STUDY: Disparities in research impact breast screening guidelines

For women at average risk of breast cancer, the United States Preventive Services Task Force (USPSTF) currently recommends beginning annual breast cancer screening at age 50. However, because these guidelines are largely based on data from white women, they may not be sensitive to racial differences.  A new study assesses the age distribution of breast cancer cases across race/ethnicity in the U.S. (6/21/18)

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STUDY: Mutations in Lynch syndrome genes MSH6 and PMS2 are associated with breast cancer

A research study published in Genetics in Medicine earlier this year shows that women with mutations in MSH6 and PMS2, two Lynch syndrome genes, have a modest (2 to 3-fold) but significantly increased risk for breast cancer. Lynch syndrome mutations have a known risk of colorectal, ovarian and uterine/endometrial cancer, as well as many other cancers. This is the first study to evaluate breast cancer risk in women with mutations in specific Lynch syndrome genes. (6/14/18)

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STUDY: XRAYS Follow Up: Does expanded genetic testing benefit Jewish women with breast cancer?

In this follow-up, we update a recent XRAYS on expanded genetic testing in Jewish women with breast cancer.  An expert in the field suggests a different interpretation of the original study than the authors. We examine the key differences in interpretation of the data. (6/7/18)

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STUDY: Should biannual MRIs replace annual mammograms in high-risk women?

The risk of breast cancer is exceptionally high in women who have a personal or family history of breast cancer or who carry a mutation in BRCA or certain other genes. More frequent screening is one strategy for early detection of breast cancer for these women. Study results presented at the 2017 San Antonio Breast Cancer Symposium suggest that MRI screening every 6 months may be more effective than the currently recommended annual breast MRI and annual mammogram in detecting early stage breast cancers-which are more treatable-in high-risk women. (2/1/18)

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ARTICLE: Dense breasts and mammograms: Jill Goodacre’s story

Korin Miller’s piece for SELF magazine focuses on why women with dense breasts may need more than a screening mammogram. Miller highlights the recent story in People magazine of Jill Goodacre, a former Victoria’s Secret model and the wife of recording artist and talk show host Harry Connick Jr. Goodacre told of her breast cancer diagnosis 5 years ago after having additional screening of her dense breast tissue following a normal mammogram.  (12/8/17)

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STUDY: Do physicians recommend breast cancer screenings based on guidelines?

Several guidelines help physicians decide when a woman should begin screening for breast cancer and how often she should be screened. However, are these guidelines put into use in the clinic? (8/8/17)

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STUDY: Routine breast cancer screening leads to overdiagnosis

Routine breast cancer screening for women of average risk has been controversial for many years because some believe that the benefits do not outweigh the risks. Recent headlines covering a study in Denmark suggests that routine breast cancer screening leads to “overdiagnosis” of breast cancer. (4/4/17)

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STUDY: Women with breast cancer symptoms but no lump may wait longer to seek medical care

Some patients take longer than others before getting a potential breast cancer checked by their health care provider. Believing that women who have breast cancer symptoms but have no lump may wait longer, researchers in this study used data from women who were diagnosed with breast cancer in 2009 and 2010 to identify possible explanations. (1/18/17)

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STUDY: Breast cancer screening should be tailored to a woman’s risk factors and breast density

The United States Preventative Services Task Force (USPSTF) recommends a screening mammogram every other year for women ages 50-74 who are at average risk for breast cancer. But do all patients in this category benefit from this screening regimen?

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ARTICLE: Dogs: Companions, hunters, and cancer detectors?

In August 2016, many news outlets published stories about how actress Shannen Doherty’s dog was able to sniff out her cancer before she was diagnosed. Is there scientific validity to that claim? (9/616)

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STUDY: Dense breast notifications are informative but hard to read and understand

Some states offer women dense breast notifications that are meant to explain that dense breasts are risk factors for breast cancer and can hide cancer on mammograms, and to identify appropriate supplemental screening options. But recent research found that this information is often not easy to read or understand, which questions the usefulness of the documents. (6/7/16)

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STUDY: How do ultrasound and mammography compare in breast cancer screening?

Mammography has been shown to reduce breast cancer deaths; however, women in developing countries don’t have easy access to mammography. Ultrasound screening, on the other hand, is portable and less expensive, and could be an alternative to mammography. This study compared mammography to ultrasound in women with dense breasts and found the two techniques have similar cancer detection rates, although the false positive rate is higher with ultrasound.

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STUDY: Mutations found through multigene panel testing for cancer risk can change patient care

Multigene panel testing can look for mutations in many genes associated with increased cancer risk. Some panels include genes associated with increased risk of multiple cancers, including breast, ovarian, colon, and gastric cancers. This study demonstrates that multigene panel tests yield findings that can change the care for patients by uncovering cancers for which they are at increased risk.

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