All XRAYs
Relevance: Medium
Most relevant for: People concerned about their risk of pancreatic cancer
Study: Bacteria and fungi in the mouth may help identify those at risk for pancreatic cancer
Pancreatic cancer often grows quickly and is usually discovered at a later stage. A better understanding of risk factors, like changes in bacteria found in the mouth, could provide doctors with early warning signs needed to help them diagnose and treat cancer sooner. The results of this study suggest that changes in bacteria and fungi in your mouth may help identify people who are at higher risk of pancreatic cancer. (Posted 11/24/25)
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Relevance: High
Most relevant for: People with an inherited mutation in ATM, BRCA1, BRCA2, CHEK2, PALB2 or a Lynch syndrome gene who have been diagnosed with breast, colorectal or pancreatic cancer
Study: Cancer patients with certain inherited mutations have cancer outcomes similar to those without inherited mutations
People with an inherited mutation in certain genes, including ATM, CHEK2, PALB2, BRCA or Lynch syndrome genes, have an increased risk of cancer. In this study, researchers wanted to know whether cancer patients with inherited mutations had a different chance of survival than patients without an inherited mutation in these genes. These results showed that, although the risk of cancer is increased, there is no difference in survival after a diagnosis of breast, pancreatic or colorectal cancer with or without these genetic changes. (posted 11/20/25)
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Relevance: High
Most relevant for: People diagnosed with early colon cancer
Study: Exercise may delay the return of colon cancer and help people live longer
People who participated in a structured exercise program following completed treatment for colon cancer experienced more time without cancer growth and lived longer than those who did not. This study suggests that regular, moderate-intensity exercise can benefit the long-term health of people with early-stage colon cancer. (Posted 11/05/25)
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Relevance: Medium-High
Most relevant for: Women with a BRCA1 or BRCA2 mutation who have a uterus.
Study: Study: Endometrial cancer risk for people with BRCA1 and BRCA2 mutations
This study looked at how often endometrial cancer occurred in people with BRCA1 or BRCA2 mutations to better understand how BRCA mutations affect the risk of endometrial cancer. The researchers also asked whether known risk factors for endometrial cancer impact the frequency of endometrial cancer in people with BRCA1 or BRCA2 mutations. Findings from the study highlight the importance of shared conversations between patients and providers regarding risk monitoring and preventive options. (posted 10/7/25)
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Relevance: High
Most relevant for: Families with a known MLH1 mutation
Study: Cancer may occur at earlier ages in later generations of families with Lynch syndrome
In families with Lynch syndrome mutations, cancer may occur at an earlier age with each generation. This study looked at the effect called anticipation in families with MLH1-associated Lynch syndrome. (Posted 10/3/25)
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Relevance: High
Most relevant for: People with metastatic castration-resistant prostate cancer
Study: Combination treatment for metastatic castration-resistant prostate cancer may be especially effective for people with BRCA1 or BRCA2 mutations
This review summarizes the results of the TALAPRO2 study. It looked at how well the PARP inhibitor Talzenna (talazoparib) works for treating metastatic castration-resistant prostate cancer (mCRPC). Talzenna appears to be most effective for people with BRCA1 or BRCA2 mutations but is also effective for people with certain other mutations. (posted 9/30/25)
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Relevance: Medium-High
Most relevant for: People newly diagnosed with early-stage breast cancer who have BRCA1 or BRCA2 mutations
Study: Breast cancer treatment combination and dose improves survival in people with inherited BRCA1 and BRCA2 mutations
Treatment before surgery with a combination of targeted therapy and chemotherapy resulted in longer survival for people with an inherited BRCA1 or BRCA2 mutation who have early-stage breast cancer. The study evaluated a new dosing strategy that made it possible to safely combine Lynparza (olaparib) and chemotherapy (carboplatin). (Posted 8/31/25)
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Relevance: Medium-High
Most relevant for: People with breast cancer or at high-risk of breast cancer
Update: FDA in the News: FDA approvals and health information on breast cancer
This XRAY review reports new treatments approved by the FDA for early and metastatic breast cancer and educational resources about women's health. (Posted 8/4/25)
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Relevance: Medium-High
Most relevant for: People with advanced, unresectable, or metastatic pancreatic cancer or NSCLC
Study: FDA approves new targeted therapy for advanced pancreatic cancer
A new treatment called Bizengri has been approved by the FDA for patients with advanced or metastatic pancreatic cancer. This treatment targets pancreatic cancer or non-small cell lung cancers that have a rare tumor mutation called an NRG1 fusion. (Posted 7/24/25)
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Relevance: Medium-High
Most relevant for: People with BRCA mutation who have textured breast implants
Study: Possible link between BRCA1 and BRCA2 mutations and rare breast implant-associated lymphoma
The causes of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare cancer that develops near implants, are unknown. Results from this study suggest that people with an inherited mutation in BRCA1 or BRCA2 may be at increased risk for BIA-ALCL. However, because very few cases of BIA-ALCL occurred among participants, more research is needed to confirm or refute this finding. (Posted 7/14/2025)
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