A Study of Fallopian Tube Removal with Delayed Ovary Removal to Lower Ovarian Cancer Risk (TUBA-WISP-II)
Prevention
Prevention study for women at high risk for ovarian cancer
Clinicaltrials.gov identifier:NCT04294927
Study Contact Information:
Name: Joanne A. de Hullu, MD, PhD
Phone Number: +31 (0) 24 36 16683
Email: [email protected]
Name: Karen H. Lu, MD, PhD
Phone Number: (713) 745-8902
Email: [email protected]
About the Study
This study is looking at whether removal of the () followed by removal of the ovaries () at a later date closer to the time of natural menopause may reduce the risk of ovarian cancer nearly as much as removing both the ovaries and at the same time (salpingo-oophorectomy) among women with an inherited , , , or mutation. Removing the only first and the ovaries at a later time closer to natural menopause may lessen menopausal symptoms while still lowering the risk for ovarian cancer.
This Study is Open To:
Women are eligible if they:
Are premenopausal with a documented in one of the genes listed below. Eligible age depends on gene mutation.
- BRCA1: 25-40
- BRCA2: 25-45
- BRIP1: 30-50
- RAD51C: 30-50
- RAD51D: 30-50
Have at least one
Do not wish to be pregnant in the future
This Study is NOT Open To:
Women cannot participate if they:
- are post-menopausal (either naturally or due to cancer treatment)
- wish for second removal of ovaries within 2 years of removing
- have a personal history of ovarian/fallopian tube or peritoneal cancer
- have had prior removal of the ()
What the Study Involves
Participants in this study will enroll in one of two groups. Participants will choose which group they enroll in based on their surgical preference.
- Group 1 will include women who choose risk-reducing removal of () with delayed .
- Group 2 will include women who choose removal of both and ovaries at the same time, (salpingo-oophorectomy) which is considered standard-of-care.
Study Contact Information:
Name: Joanne A. de Hullu, MD, PhD
Phone Number: +31 (0) 24 36 16683
Email: [email protected]
Name: Karen H. Lu, MD, PhD
Phone Number: (713) 745-8902
Email: [email protected]
Locations:
Illinois
City: Chicago RECRUITING
Facility: UChicago Medicine
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Massachusetts
City: Boston RECRUITING
Facility: Dana Farber Cancer Institute
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Minnesota
City: Rochester RECRUITING
Facility: Mayo Clinic
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Missouri
City: St Louis RECRUITING
Facility: Washington University Medical Center
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North Carolina
City: Durham RECRUITING
Facility: Duke University Hospital
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New York
City: New York RECRUITING
Facility: Mount Sinai Hospital
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City: New York RECRUITING
Facility: Memorial Sloan Kettering Cancer Center
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Pennsylvania
City: Philadelphia RECRUITING
Facility: Hospital of the University of Pennsylvania
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Texas
City: Houston RECRUITING
Facility: Harris Health Lyndon B. Johnson Hospital
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City: Houston RECRUITING
Facility: MD Anderson Cancer Centre
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Washington
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Facility: University of Washington
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Other Countries
Country: Australia
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Facility: The Mater Hospital
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Facility: Instituto Nacional de Cancerología
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State: Gelderland
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City: Stockholm RECRUITING
Facility: Karolinksa Institutet
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Country: Uruguay
City: Montevideo RECRUITING
Facility: Hospital Británico
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Prevention
Prevention study for women at high risk for ovarian cancer
Clinicaltrials.gov identifier:NCT04294927
Study Contact Information:
Name: Joanne A. de Hullu, MD, PhD
Phone Number: +31 (0) 24 36 16683
Email: [email protected]
Name: Karen H. Lu, MD, PhD
Phone Number: (713) 745-8902
Email: [email protected]