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Study Contact Information:

MD Anderson Cancer Center    
Contact: Sandra Montez, RN by phone: 713-745-6274 or by email.    
or

Haihe Pharmaceuticals
Jason Sudia, PhD, MPH by email or Frank Tan, MD by email

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Testing the New Targeted Therapy CYH33 in Combination With the PARP Inhibitor Olaparib in People With Advanced Solid Tumors and DNA Damage Repair Mutations

Study Contact Information:

MD Anderson Cancer Center    
Contact: Sandra Montez, RN by phone: 713-745-6274 or by email.    
or

Haihe Pharmaceuticals
Jason Sudia, PhD, MPH by email or Frank Tan, MD by email

PRINTER FRIENDLY PAGE
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About the Study

This study is no longer recruiting patients. 

This study will look at safety and effectiveness of the  CYH33 combined with the olaparib in people with advanced cancers and a damage repair (DDR) gene mutation whose cancer got worse on, or after receiving a PARP inhibitor. The study will also enroll people with recurrent, platinum resistant ovarian cancer. In addition to safety and efficacy, the study will test whether the combination of CYH33 and can block tumor growth and overcome a patient’s resistance to PARP inhibitor treatment.        

This Study is Open To:

This study is no longer recruiting patients. 

This Study is NOT Open To:

This study is no longer recruiting patients. 

What the Study Involves

  • Patients will receive CYH33 once per day orally in combination with 300 mg olaparib two times per day orally.
  • Study participants will be followed for 38 months.

Type of Study

  • This is an study. All participants will receive both CYH33 and olaparib. The study will enroll several different groups of people based on their tumor type and or genetic test results. 
     

Study Site

Texas

Houston
MD Anderson Cancer Center    
Contact: Sandra Montez, RN by phone: 713-745-6274 or by email.    
Principal Investigator: Timothy Yap, MD

Study Contact Information:

MD Anderson Cancer Center    
Contact: Sandra Montez, RN by phone: 713-745-6274 or by email.    
or

Haihe Pharmaceuticals
Jason Sudia, PhD, MPH by email or Frank Tan, MD by email